Piotr
przeczytaj chociaż abstrakt tego badania, którego opis podałeś
co innego jest w abstrakcie a co innego pisze ten koleś z MD
Abstract
Despite the widespread consumption of non-steroidal anti-inflammatory drugs (NSAIDs),
the influence of these drugs on muscle satellite cells is not fully understood. The aim of the
present study was to investigate the effect of local NSAID infusion on satellite cells
following unaccustomed eccentric exercise in vivo in human skeletal muscle. Eight young,
healthy males performed 200 maximal eccentric contractions with each leg. NSAID was
infused via a microdialysis catheter into m. vastus lateralis of one leg (NSAID leg) before,
during and for 4.5 hrs after exercise, the other leg working as control (unblocked leg).
Muscle biopsies were collected before and 8 days postexercise. Changes in satellite cell
and inflammatory cell number were investigated by immunohistochemistry. Satellite cells
were identified using antibodies against neural cell adhesion molecule (NCAM) and Pax7.
The number of Pax7+ cells per myofiber was increased by 96 % on day 8 post exercise in
the unblocked leg (mean 0.14 (SE 0.04)) compared with pre (0.07 (0.02) P<0.05), while the
number of Pax7+ cells was unchanged in the leg muscles exposed to NSAID (0.07 (0.01)).
The number of inflammatory cells (CD68+ or CD16+) was not significantly increased in
either of the legs 8 days post exercise and was unaffected by NSAID. The main finding in
the present study was that NSAID infusion for 7½ hours during the exercise day suppressed the exercise-induced increase in the number of satellite cells 8 days post exercise. These
results suggest that NSAIDs negatively affect satellite cell activity following unaccustomed
eccentric exercise.
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Ja czytałem tez inne badanie tylko nie moge znaleźć już linka - 800 mg ibuprofenu podanego niedługo
przed treningiem zatrzymywało hipertrofię mięśnie
pozatym na logike - NLPZ działają przeciwzapalnie, a jak już wiemy stan zapalny mięśni po treningu jest konieczny do ich rozwoju!
Zmieniony przez - MolderDist w dniu 2010-10-12 23:00:41