Tauryna i jej potencjalne wykorzystanie w terapii*

W ogóle, mało ludzi zdaje sobie chyba sprawę z tego, jak niewiele supli w widoczny sposób wpływa na formę panuje powszechne przekonanie, że wystarczy cykl na mono i z ekto robi się bydle dodaj do tego super anaboliczne BCAA i przybywają następne kg czystego mięcha, a jak dorzucisz najlepszy antykatabolik na świecie - taurynę, to nie zmieścisz się w drzwiach w ciągu 2 miechów.

fafatq, cześć w końcu mam czas aby poczytać Twój i Konia dział.

Słuchaj pamiętasz jak rozmawialiśmy jakiś czas temu i o ile dobrze pamiętam wspomniałeś o Taurynie jako wspomagaczu pracy wątroby.

Jak będziesz miał chwile mógłbyś coś więcej napisać ??

kilka badan nie koniecznie bezposrednio zwiazanych z wykorzystaniem tauryny w bb,ale moze sie przyda

tauryna a nadcisnienie/choroby ukladu krążenia

The potential health benefits of taurine in cardiovascular disease.

Abstract

Taurine (2-aminoethanesulphonic acid), a sulphur-containing amino acid, is found in most mammalian tissues. Although it can be synthesized endogenously, the major source of taurine is from the diet. Taurine was found to exhibit diverse biological actions, including protection against ischemia-reperfusion injury, modulation of intracellular calcium concentration, and antioxidant, antiatherogenic and blood pressure-lowering effects. The present review will address the potential beneficial actions of taurine in congestive heart failure, hypertension, ischemic heart disease, atherosclerosis and diabetic cardiomyopathy. There is a wealth of experimental information and some clinical evidence available in the literature suggesting that taurine could be of benefit in cardiovascular disease of different etiologies. However, double-blind long-term clinical trials need to be conducted before taurine can be unequivocally recommended as a nutritional intervention for the prevention and/or treatment of cardiovascular disease.

http://www.ncbi.nlm.nih.gov/pubmed/19343117

suplementacja tauryna moze byc skuteczna w walce z uszkodzeniami reperfuzyjnymi,modulowaniu koncetracji wapnia wewnątrzkomorkowego ,wlasciwosci przeciw miażdżycowe i obnizające cisnienie krwi


Taurine in cardiovascular disease.

PURPOSE OF REVIEW: The shift of modern dietary regimens from 'Mediterranean' to 'western' style is believed to be responsible, in part, for the increase in cardiovascular disease, obesity, type II diabetes and cancer. A classic 'Mediterranean' diet consists of adequate intake of seafood, vegetables, fruit, whole grain and nonpurified monounsaturated vegetable oil. Thus, in humans, dietary intake of seafood is the major source of taurine, as the level of endogenously produced taurine is low.

RECENT FINDINGS: Taurine has been shown to affect coronary artery disease, blood pressure, plasma cholesterol and myocardial function in animal models of human disease. A major role of taurine is to act as an antioxidant and absorb hypochlorous acid but not the oxidative radical. It seems that this beneficial effect of taurine in antioxidant therapy has not been well promoted.

http://www.ncbi.nlm.nih.gov/pubmed/21076292

suplementacja tauryna mnoze byc skuteczna w walce z chorobami ukladu krążenia,ale jej rola jako antyoksydant polega na absorbowaniu kwasu podchlorawego (HOCI) ,a nie wolnych rodnikow


Treatment of hypertension with oral taurine: experimental and clinical studies.

Oral taurine treatment has been studied extensively as a hypotensive agent. Several rat models of hypertension have been used to prove that dietary taurine supplementation can alleviate high blood pressure, among other cardiovascular problems. Experimental models mentioned in this review are the spontaneously hypertensive rat, the DOCA-salt rat, the Dahl-S rat, the renovascular hypertensive rat, the hyperinsulinemic rat and the ethanol-treated rat. The beneficial effects of taurine were also demonstrated in studies involving human subjects suffering essential hypertension. Taurine supplementation of 6 g/day for as little as 7 days resulted in measurable decreases in blood pressure in these patients. In both rat and human studies, the effects of taurine appeared to be dependent on the modulation of an overactive sympathetic system. However, taurine has positive effects on other types of cardiovascular problems and thus may act through more than one mechanism.

http://www.ncbi.nlm.nih.gov/pubmed/12436205

suplemnetacja tauryna obnizyla cisnienie tętnicze u badanych osob


[Central hypotensive effect involving neurotransmitters of long-term administration of taurine to stroke-prone spontaneously hypertensive rat].

BACKGROUND: Taurine is an inhibitory neurotransmitter or neuromodulator that reduces blood pressure when systemically or centrally administered. We studied the central hypotensive effects of long-term oral taurine administration.

METHODS: Arterial blood pressure was measured after delivering an intracisternal injection of 100 mg x 20 microl(-1) or 200 microg x 20microl(-1) of taurine in normal saline, or 20 micro1 normal saline to anesthetized Sprague-Dawley rats. Drinking water containing 3% taurine was administered to stroke-prone spontaneously hypertensive rats (SHRSP) from the age of 4 weeks. Amino acids and monoamine neurotransmitters in the cerebrospinal fluid were measured at 8, 12, 16, 18 weeks of age in taurine treated SHRSP and normotensive Wistar Kyoto rats (WKY) and in untreated SHRSP using high performance liquid chromatography.

RESULTS: Intracisternal injections of taurine caused a dose dependent decrease in arterial blood pressure. Although concentrations of taurine decreased in treated SHRSP rats in an age-related manner, the drug persistently suppressed the development of hypertension. The values of excitatory amino acids and GABA, norepinephrine, NMN, dopamine metabolites, serotonin and its metabolite were lower in taurine-treated SHRSP than those in untreated SHRSP.

CONCLUSIONS: Taurine reduces blood pressure through not only direct inhibition of the cardiovascular center in the medulla, but also by reducing brain monoamine concentrations.

http://www.ncbi.nlm.nih.gov/pubmed/17315726

suplementacja tauryną obnizylo cisnienie krwi


The in vivo and in vitro protective properties of taurine.

1. Taurine is a ubiquitous, free amino acid found in mammalian systems. 2. The biological functions of taurine are unclear. 3. Various in vivo data suggest that taurine has a variety of protective functions and deficiency leads to pathological changes. 4. Depletion in rats of taurine increases susceptibility to liver damage from carbon tetrachloride. 5. Susceptibility to a variety of hepatotoxicants correlates with the estimated hepatic taurine level. 6. In vitro data suggest that taurine can protect cells against toxic damage. 7. Taurine protects isolated hepatocytes against carbon tetrachloride, hydrazine and 1,4-naphthoquinone but not against allyl alcohol, alpha-naphthylisothiocyanate (ANIT) or diaminodiphenyl methane (DAPM) cytotoxicity. 8. The mechanisms of protection are unclear but may include modulation of calcium levels, osmoregulation and membrane stabilization.

http://www.ncbi.nlm.nih.gov/pubmed/7789717

-biologiczna rola tauryny jest nie do konca poznana
-wiele badan pokazala ze tauryna ma szereg wlasciowsci ochronnych
-szury z deficytem tauryny sa bardziej podatne na uszkodzenia watroby spowodowane czterochlorkiem węgla
-badania sugeruja ze taurtyna moze chronic komorki przed dzialniem toksyn
-tauryna wykazuje ochronne dzialanie przeciwko czterochlorkiem węgla,hydrazyną, 1,4-naftochinon ale nie przed ytotoksyczność przed alkoholem allilowym,alfa izotocyjanianem naftylu i diaminodifenylometanem


Zmieniony przez - solaros w dniu 2011-02-03 15:40:50

Brief Background:

Taurine - a nonessential amino acid-like compound, taurine is found in high abundance in the tissues of many animals, especially sea animals, and in much lower concentrations in plants, fungi, and some bacteria. As an amine, taurine is important in several metabolic processes of the body, including stabilizing cell membranes in electrically active tissues, such as the brain and heart. It also has functions in the gallbladder, eyes, and blood vessels, and may have some antioxidant and detoxifying properties.

Several taurine derivatives are being investigated for medical use, such as taltrimide as an antiepileptic drug. Other taurine derivatives in various stages of development include acamprosate (antialcoholic), tauromustine (anticancer), and tauroursodeoxycholic acid (liver disorders).

The efficacy of taurine has been investigated for diabetes, hypertension, cystic fibrosis, liver disorders, cardiovascular disorders, and nutritional support. Taurine is added to many infant formulas based on the decreased ability to form taurine from cysteine in this population.

jabolcokk - OK, poszukam jeszze, w tej chwili nie pamiętam gdzie to było

solaros - dwa pierwsze badania musze sobie przejrzeć w pełnych tekstach

etios_ - warto podać zrodło, autora, krociutkie podsumowanie po polsku no i jakieś konkrety

solaros wiesz o ile obniży 3 gram tauryny branej ciągle, w umiarkowanie ciężkim nadciśnieniu ?

Stawiam na 10 jednostek skurczowego a wy ?

Ja miałem najwięcej 175 na 110 , zaniedbałem aeroby i inne rzeczy .

10 jednostek to myślę iż jest sporo, raczej wątpię w taką moc

to bardzo wysoko oceniane w próbach klicznicznych połaczenie omega 3 + czosnek nie miało takiego potencjału

poza tym ten dział nie jest miejscem od "obstawiania" wyników, tutaj liczą się precyzyjne dane

tu jest badane na szczurach dzialanie ochronne przeciwko cyklosporynie (lek o działaniu immunosupresyjnym)

cisnienie drastycznie wzroslo - poza grupa ktora spozywala tauryne

'1. Cyclosporine A (CsA) is the first-line immunosuppressant
used for the management of solid organ transplantation and
autoimmune diseases. Nephrotoxicity is the major limitation of
CsA use. Recent evidence suggests that reactive oxygen species
(ROS) play an important role in mediating CsA-induced hypertension
and nephrotoxicity. Taurine, the major intracellular free
b-amino acid, is known to be an endogenous anti-oxidant and
membrane-stabilizing agent. The present study was designed to
investigate the effects of taurine on CsA-induced oxidative stress,
hypertension and renal dysfunction.
2. Animals were assigned into four groups of seven rats each
as follows: (i) control group, receiving vehicle (olive oil; 1 mL/kg,
s.c.); (ii) CsA group, given CsA (25 mg/kg per day, s.c.) for
21 days; (iii) taurine group, supplemented with taurine (1% in
the drinking water); and (iv) taurine + CsA group, treated with
taurine 3 days before and concurrently during CsA injections
for 21 days.
3. Cyclosporine A administration elevated blood pressure,
reduced serum nitric oxide (NO) levels and deteriorated renal
function, as assessed by increased serum creatinine levels and
proteinuria and reduced urine flow rate and creatinine clearance
compared with vehicle-treated rats. Cyclosporine A induced
oxidative stress, as indicated by increased renal tissue concentrations
of thiobarbituric acid-reactive substances and reduced
concentrations of renal glutathione, glutathione peroxidase and
superoxide dismutase. Conversely, no change was noted in renal
catalase activity. Moreover, the kidneys of CsA-treated rats
showed interstitial inflammation and renal tubular atrophy.
4. Taurine markedly reduced elevated blood pressure, attenuated
renal dysfunction and the reduction in serum NO levels
and counteracted the deleterious effects of CsA on oxidative
stress markers. Furthermore, taurine ameliorated CsA-induced
morphological changes.
5. These data clearly indicate the protective potential of
taurine against CsA-induced hypertension and nephrotoxicity

http://repository.ksu.edu.sa/jspui/bitstream/123456789/5213/3/TAURINE.pdf

General: Taurine is a conditionally essential amino acid also known as 2-aminoethanesulfonic acid. Taurine is found in high levels in protein-rich foods, such as meat and fish, as well as in breastmilk. Taurine is normally synthesized in the human body in adequate amounts from other amino acids, including cysteine.

Antiepileptic effects: Although the antiepileptic mechanisms of taurine are not yet clear, it has been suggested that taurine can modulate calcium homeostasis. However, the administration of taltrimide (2-phthalimidoethanesulphon-N-isopropylamide), a lipophilic derivative of taurine, to epileptic patients led to increases in seizure frequency. This study also found increases in phenytoin concentration and decreases in serum carbamazepine concentrations during taltrimide treatment.

Antihypertensive effects: Taurine may affect the plasma levels of catecholamines, in particular, causing decreases in plasma epinephrine.

Antioxidant effects: In a human study, lipoperoxidation following coronary artery bypass grafting was reduced, indicating that taurine may be a free-radical scavenger.

Embryo development effects: Taurine at a concentration of 5mM/L has been shown to support the development of human embryos (blastocyte stage) in vitro.

Fat absorption/malnourishment effects: In clinical study, supplementation with taurine altered glycine/taurine bile acid conjugation patterns. This may result in a shift towards a more hydrophilic bile acid pool. Taurine may improve the micellar phase of fat digestion. In clinical trials of human infants, taurine-supplemented formula increased absorption of fat, particularly saturated fat. The same was observed in cystic fibrosis patients supplemented with taurine. Decreased fecal fatty acid excretion, affecting mainly saturated fat and monounsaturated fat, decreased total sterol excretion, and enhanced secretion and conjugation of bile have also been noted in clinical trials involving cystic fibrosis and biliary patients.

Lipid metabolism effects: In human study with healthy subjects, oral supplementation ameliorated increases in total cholesterol and low density low-density lipoprotein, but with the potential tradeoff of elevating very low density lipoprotein, very low density lipoprotein cholesterol, and triglyceride levels. These effects may be mediated by the effect of taurine on lipoprotein lipase.

Liver disease: A taurine-supplemented diet may enhance the secretion of taurocholic acid, glycocholic acid, taurochenodeoxycholic acid, glycochenodeoxycholic acid, and total bile acid in patients with biliary atresia. In humans in patients undergoing liver transplantation, the conjugation of taurine to ursodeoxycholic acid (tauroursodeoxycholic acid, TUDCA), did not affect graft function or survival, above immunosuppression therapy alone.

Milei, J., Ferreira, R., Llesuy, S., Forcada, P., Covarrubias, J., and Boveris, A. Reduction of reperfusion injury with preoperative rapid intravenous infusion of taurine during myocardial revascularization. Am.Heart J. 1992;123(2).

Galeano, N. F., Darling, P., Lepage, G., Leroy, C., Collet, S., Giguere, R., and Roy, C. C. Taurine supplementation of a premature formula improves fat absorption in preterm infants. Pediatr.Res. 1987;22(1).

Belli, D. C., Levy, E., Darling, P., Leroy, C., Lepage, G., Giguere, R., and Roy, C. C. Taurine improves the absorption of a fat meal in patients with cystic fibrosis. Pediatrics 1987;80(4).

Smith, L. J., Lacaille, F., Lepage, G., Ronco, N., Lamarre, A., and Roy, C. C. Taurine decreases fecal fatty acid and sterol excretion in cystic fibrosis. A randomized double-blind trial. Am.J.Dis.Child 1991;145(12).

Darling, P. B., Lepage, G., Leroy, C., Masson, P., and Roy, C. C. Effect of taurine supplements on fat absorption in cystic fibrosis. Pediatr.Res. 1985;19(6).

Mizushima, S., Nara, Y., Sawamura, M., and Yamori, Y. Effects of oral taurine supplementation on lipids and sympathetic nerve tone. Adv.Exp.Med.Biol. 1996;403.

Fujita, T., Ando, K., Noda, H., Ito, Y., and Sato, Y. Effects of increased adrenomedullary activity and taurine in young patients with borderline hypertension. Circulation 1987;75(3).

Wang, W. Y. and Liaw, K. Y. Effect of a taurine-supplemented diet on conjugated bile acids in biliary surgical patients. JPEN J.Parenter.Enteral Nutr. 1991;15(3).

Koivisto, K., Sivenius, J., Keranen, T., Partanen, J., Riekkinen, P., Gothoni, G., Tokola, O., and Neuvonen, P. J. Clinical trial with an experimental taurine derivative, taltrimide, in epileptic patients. Epilepsia 1986;27(1).

Devreker, F., Van den, Bergh M., Biramane, J., Winston, R. L., Englert, Y., and Hardy, K. Effects of taurine on human embryo development in vitro. Hum.Reprod. 1999;14(9).

Angelico, M., Tisone, G., Baiocchi, L., Palmieri, G., Pisani, F., Negrini, S., Anselmo, A., Vennarecci, G., and Casciani, C. U. One-year pilot study on tauroursodeoxycholic acid as an adjuvant treatment after liver transplantation. Ital J Gastroenterol.Hepatol. 1999;31(6).

Trenkner, E., El Idrissi, A., Dumas, R., and Rabe, A. Functional consequences of calcium uptake modulation by taurine in vivo and in vitro. Adv.Exp Med Biol 1998;442.

El Idrissi, A. and Trenkner, E. Growth factors and taurine protect against excitotoxicity by stabilizing calcium homeostasis and energy metabolism. J Neurosci 11-1-1999;19(21).

Fitzpatrick, W. J., Zentler-Munro, P. L., and Northfield, T. C. Ileal resection: effect of cimetidine and taurine on intrajejunal bile acid precipitation and lipid solubilisation. Gut 1986;27(1).

Setchell, K. D., Rodrigues, C. M., Podda, M., and Crosignani, A. Metabolism of orally administered tauroursodeoxycholic acid in patients with primary biliary cirrhosis. Gut 1996;38(3).

etios_ - Taurine may affect the plasma levels of catecholamines, in particular, causing decreases in plasma epinephrine - ciekawe, zwłaszcza w kontekscie stosowania np tauryny ze spalaczmi


no i bibliografia ciekawa

na przyszłośc proszę zważ na moją prośbę którą zamieściłem wyżej, czyli źrodło (bo nie podałeś) i krótkie nawet podsumowanie po polsku.

pzdr