*** Hardkorowy - NIEHORMONALNY - zestaw suplementów!

.....kolejny element skladanki.

Mial byc typowy BOOSTER TESTOSTERONU - ale jak wiadomo w wiekszosci przypadków kazda 'roslinka' przewaznie ma wielorakie dzialanie,wiec nie tylko buzer tescia ale takze inne prozdrowtone wlasciwoscia:

3)

Horny Goat Weed -> ICARIIN



W języku chińskim Horny Goat Weed nosi nazwę "Yin Yang Huo". Nazwa naukowa to Herba Epidemii. Jest to kwitnąca roślina rosnąca w dużych ilościach w Chinach, jak i pewnych obszarach Azji.





Ten gatunek należy do rodziny berberysowatych (Berberidaceae). Horny goat weed to mrozoodporna roślina wieloletnia. Kwiaty mają po cztery płatki.
W tradycji chińskiej jest legenda o pasterzu kóz, który odkrył, że to ziele stymulowało pociąg seksualny u jego kóz, po tym jak je zjadły. Dlatego też to zioło znane jest powszechnie w Chinach jako "horny goat weed" (ziele podnieconej kozy).





Ogólnie uważa się, że jest wspaniałą alternatywą viagry dla mężczyzn z problemami z potencją. Naukowcy zbadali to zioło i potwierdzili, że Epidemii wykazuje właściwości afrodyzjaka. Odkryli aktywny składnik: Icariin. Icariin może podnieść poziom tlenku azotu, który z kolei odpręża mięśnie gładkie. Naukowcy odkryli, że icariin rozluźnia tkankę prącia u królika. Poza tym badania wykazały, że u szczurów (po wstrzyknięciu ekstraktu Epidemium bezpośrednio w penisa) wzrosło ciśnienie krwi w penisie. Naukowcy wskazują, iż icariin może blokować PDE5, czyli enzym zmniejszający przepływ krwi do penisa, a zatem uniemożliwiający erekcję. Stąd wniosek, że głównie icariin odpowiada za właściwości afrodyzjakalne Epidemium.
Rzeczywiście, zioło to jest zazwyczaj przepisywane przez specjalistów tradycyjnej medycyny chińskiej jak lek na impotencję, wraz z innymi ziołami. Jest powszechnie dostępny na rynku azjatyckim i spożywany jako suplement diety


IKARYNA - Istotnie zarówno doświadczenia empiryczne, jak i badania naukowe wskazują na możliwości zwiększenie libido za sprawą ikaryn. Zwiększa ona ukrwienie i unaczynienie naczyń kapilarnych w mięśniach i narządach płciowych. Daje to możliwość stosowania jej zarówno dla polepszenia funkcji seksualnej, jak i polepszenia jakości treningu. Okazało sie bowiem, że pełni ona rolę mediatora w powstawaniu tlenku azotu.
Niezwykle ciekawy okazuje się mechanizm działania ikaryn na uklad hormonalny. Dowiedziono, że zdolne są do kontroli poziomu testosteronu i kortyzolu. Właściwie powodują wzrost poziomu naszego endogennego testosteronu przy jednoczesnej redukcji katabolicznego hormonu kortyzolu, określanego często jako hormon stresu.
Kortyzol powoduje tez bezpośrednie obniżenie sprawności seksualnej i odbieranie ochoty do współżycia. Dlatego własnie modulacja poziomu tych dwóch hormonów w organizmie mężczyzny jest taka ważna. Badania wykazały, że substancje aktywne tej rośliny działają adaptogennie. Wpływają także na prawidłowy poziom adrenaliny, noradrenaliny, serotoniny i dopaminy. Umożliwia to nie tylko kontrolę prawidłowego stanu metabolizmu, ale działa także antydepresyjnie, tonizująco.
Ważnym aspektem wydaje sie też podniesienie poziomu hormonów tarczycowych przy jednoczesnym wzroście poziomu testosteronu, co wpływa niewątpliwie na budowanie beztłuszczowej masy mięsniowej. Równie ważne jest działanie immunomodulujące polegające na wzroście ogólnej odporności organizmu przed infekcjami. Naukowo potwierdzono także, że związki czynne Epimedium poprawiają stan tkanki kostnej i doskonale chronią watrobę przed wszelkimi uszkodzeniami.


Badania 1:


Icariin a - TESTOSTERON

A)

To evaluate the testosterone mimetic properties of icariin.
METHODS: Forty-eight healthy male Sprague-Dawley rats at the age of 15 months were randomly divided into four groups with 12 rats each: the control group (C), the model group (M), the icariin group (ICA) and the testosterone group (T). The reproductive system was damaged by cyclophosphamide (intraperitoneal injection, 20 mg/kg x day) for 5 consecutive days for groups M, ICA and T, at the sixth day, ICA (gastric gavage, 200 mg/kg x day) for the ICA group and sterandryl (subcutaneous injection, 5 mg/rat . day) for the T group for 7 consecutive days, respectively. The levels of serum testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH), serum bone Gla-protein (BGP) and tartrate-resistant acid phosphatase activity in serum (StrACP) were determined. The histological changes of the testis and the penis were observed by microscope with hematoxylin-eosin (HE) staining and terminal deoxynucleotidyl transferase biotin-dUTP-X nick end labeling (TUNEL), respectively. RESULTS: (1) Icariin improved the condition of reproductive organs and increased the circulating levels of testosterone. (2) Icariin treatment also improved the steady-state serum BGP and might have promoted bone formation. At the same time, it decreased the serum levels of StrACP and might have reduced the bone resorption. (3) Icarrin suppressed the extent of apoptosis of penile cavernosal smooth muscle cells. CONCLUSION: Icariin has testosterone mimetic properties and has therapeutic potential in the management of hypoandrogenism.


This study utilized 4 groups-
1) Control (eugonadal)
2) Model (induced testicular injury)
3) Icariin (induced testicular injury + Icariin)
4) Testosterone (induced testicular injury + Testosterone)

After 7 days, blood was withdrawn and analyzed:

Results:
For the Icariin group, the total testosterone went up about 3.6x normal with a slight decrease in both FSH and LH. The weights of the testis, epididymis, and seminal vesicles were not statistically significant compared to control.

The Testosterone group, on the other hand, elevated testosterone 11.7x normal, with statistically significant increases in both LH and FSH. The weights of the testis, epididymis, and seminal vesicles were all elevated compared to control.

It is important to note that the Icariin group had lower epididymal weight, lower FSH, and lower LH then control and the M group.

Zhang ZB, Yang QT.
Department of Urology, Second Affiliated Hospital, Shantou University Medical College, Shantou 515041


B)

Aim: To investigate the influence of an extract obtained from five Chinese medicinal plants on sexual behavior of adult male rats. Methods: The extract was administered at doses of 30, 60 and 120 mg/kg by oral gavage, acutely (one time, 45 min before mating test) or subchronically (daily for 10 days) in sexually potent and sexually sluggish/impotent rats. Sexual behavior, serum levels of luteinizing hormone (LH) and testosterone (T) were evaluated in treated rats and compared with controls receiving vehicle. The effect of the extract on central dopaminergic neurotransmission was assessed in the nucleus accumbens using a microdialysis technique. Results: In sexually potent rats, both acute and subchronic treatment with the extract dosed at 30 and 60 mg/kg reduced mount latency and intromission latency. In sluggish/impotent rats, the acutely administered extract at the dose of 60 mg/kg shortened ejaculation latency, whereas subchronically administered at the doses of 30 and 60 mg/kg, reduced mount, intromission and ejaculation latencies, increasing also the percentage of mounting and ejaculating rats. The extract dosed at 60 mg/kg significantly increased LH and T following acute and subchronic administration and increased 3,4-dihydroxyphenylacetic acid levels in the nucleus accumbens, 30 min after the acute administration.
Conclusion: The improvement in both appetitive and consummatory components of sexual behavior observed in male rats treated with the extract could be ascribed to increased serum T level in parallel with the activation of the central dopaminergic system.

http://onlinelibrary.wiley.com/doi/10.1111/j.1745-7262.2008.00437.x/abstract

C)

It had been found that Yang-restoring herb medicines Radix Aconiti Praeparata (AP), Cortex Cinamomi(CC), Herba Cistanchis(HC) and Epimedium brevicorum (EB) reduced the cold-resistant potential of normal mice and disturbed the balance of thyroid hormones in normal rats. The aim of this study was to further investigate the effects of these four herb medicines on the levels of plasma corticosterone (B), testosterone (T) and triiodothyronine (T3) in rats by administering herbs together (mixed group) or individually. It was shown that all four Yang-restoring herbs tended to raise plasma B level and it was significant in HC, EB and mixed groups, especially in HC administered rats (P less than 0.001). Rise of plasma T level was seen in CC and mixed groups. All four herbs could decrease plasma T3 level and it was significant in AP, CC and mixed groups, particularly evident in AP administered rats (P less than 0.001). This may be one of the adaptating-protecting mechanisms of normal organism against the toxicity of AP. Combination of the four herb medicines did not result in the cumulation of effects of the given medicines, however, this did reflect the average effect of these four herbs, which showed a restraining and harmonious relationship in a Chinese medical prescription.

http://www.ncbi.nlm.nih.gov/pubmed/2624991

D)

In this report, the traditional idea that sheep fat processed Herba Epimedii warms the kidney and thus invigorate "Yang" has been tested and verified by modern pharmacological methods. Experimental findings indicate that raw Herba Epimedii does not help improve the sexual function, while well processed Herba Epimedii produces apparent effects on the improvement of sexuality.

http://www.ncbi.nlm.nih.gov/pubmed/2511870?dopt=Abstract&holding=npg

E)

The present study evaluated the effects of icariin (the main component of Epimedium herbs) and an extract of Cuscuta seeds on the development of the sex organs of immature male mice in vivo and on the functions of rat Leydig cells in vitro. Icariin increased the wts. of the immature mouse epididymis and seminal vesicles. Cuscuta seed extract had the same effect on the testis and epididymis, but was not as potent as human chorionic gonadotropin. In the culture medium of adult rat Leydig cells, icariin increased basal testosterone secretion and cAMP production Cuscuta seed extract enhanced basal and gonadotropin-stimulated testosterone secretion. The results suggest that icariin possesses an androgen-like effect and may increase testosterone secretion via an action on cAMP. Cuscuta seed extract acts mainly like gonadotropic hormone.

http://chemport.cas.org/cgi-bin/sdcgi?APP=ftslink&action=reflink&origin=npg&version=1.0&coi=1:CAS:528:DyaK2cXkvF2ks7w=&pissn=1008-682X&pyear=2006&md5=8179b29d69adff423e7bc4adf494350b


Badania 2:

Icariin a - Zaburzenia erekcji & libido

A)

To investigate the effect of icariin on erectile function and the expression of nitric oxide synthase (NOS) isoforms in castrated rats. METHODS: Thirty-two adult male Wistar rats were randomly divided into one sham-operated group (A) and three castrated groups (B, C and D). One week after surgery, rats were treated with normal saline (groups A and B) or oral icariin (1 mg/[kg.day] for group C and 5 mg/[kg.day] for group D) for 4 weeks. One week after treatment, the erectile function of the rats was assessed by measuring intracavernosal pressure (ICP) during electrostimulation of the cavernosal nerve. The serum testosterone (ST) levels, the percent of smooth muscle (PSM) in trabecular tissue, and the expression of mRNA and proteins of neuronal nitric oxide synthase (nNOS), inducible nitric oxide synthase (iNOS), endothelial nitric oxide synthase (eNOS) and phosphodiesterase V (PDE5) in corpus cavernosum (CC) were also evaluated. RESULTS: ICP, PSM, ST and the expression of nNOS, iNOS, eNOS and PDE5 were significantly decreased in group B compared with those in group A (P 0.01). However, ICP, PSM and the expression of nNOS and iNOS were increased in groups C and D compared with those in group B (P 0.05). Changes in ST and the expression of eNOS and PDE5 were not significant (P 0.05) in groups C and D compared with those in group B.
CONCLUSION: Oral treatment with icariin ( 98.6 % purity) for 4 weeks potentially improves erectile function. This effect is correlated with an increase in PSM and the expression of certain NOS in the CC of castrated rats. These results suggest that icariin may have a therapeutic effect on erectile dysfunction.


http://onlinelibrary.wiley.com/doi/10.1111/j.1745-7262.2005.00066.x/abstract
Asian J Androl. 2005 Dec;7(4):381-8.
Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats.

Liu WJ, Xin ZC, Xin H, Yuan YM, Tian L, Guo YL

B)

We tested the effect of icariin on erectile function of the penis. Icariin, sidenafil and papaverine increased the intracavernous pressure in a dose-depended manner. Icariin increases intracavernous pressure.

Zhonghua Yi Xue Za Zhi. 2004 January.

C)

In the present study, we investigated the inhibitory effect of icariin on PDE5 and PDE4 with papaverine as the control drug. Icariin and papaverine had a dose-dependent inhibitory effect on PDE4 and PDE5. Our previous studies showed that icariin significantly increased the cGMP levels of penile and clitoral CC in rabbits [20, 21]. In conclusion, icariin has a selective inhibitory effect on cGMP-specific PDE5 compared to cAMP-specific PDE4 and may be developed into an oral effective agent useful for the treatment of ED.

http://www.asiaandro.com/archive/1008-682X/5/15.htm

D)

Herba of Epimedium koreanum is used in
traditional Chinese and Korean herbal medicine as a potent enhancer of erectile function. Icariin, the main active component of Epimedium koreanum,possesses many biological effects, such as improving cardiovascular
function, hormone regulation, immunological function modulation, and anti-tumor activity. AIM OF THE STUDY: This study supports the traditional use of extracts from Epimedium species in erectile dysfunction. MATERIALS
AND METHODS: The Epimedium koreanum dry extract was suspended in wheat germ oil using lecithin and bee wax for oral administration. The effect of oral
administration of two compositions (E-01 and E-02) standardized by their icariin content on the number of complete intromissions, the number of
ejaculations, and the latent period of ejaculation (LPE) in rats were evaluated. E-01 and E-02 were administered orally for 10 days to the experimental animals. The control animals received olive oil for 10 days. On
day 10, 0.5h after the dose was administered to male rats, one virgin female rat was placed with one male rat. RESULTS: The number of complete intromissions increased to 23.3+/-2.6 in the E-01 and E-02 group (dose 300
mg/kg body weight) (b.wt) and to 20.1+/-2.3 in the E-02 group (dose 750 mg/kg b.wt) compared with 15.2+/-2.4 in the control group of aged rats. The number of ejaculations increased from 1.1+/-0.3 in the control-aged group to
2.6+/-0.4 in the E-01 group. The LPE of male rats was 14.2+/-1.8 min in the control-aged group. The LPE of the aged group was reduced to 9.8+/-1.5 min,
9.8+/-1.6 min, and 11.4+/-1.8 min when treated with E-01 at a dose of 300mg/kg b.wt, and E-02 at a dose of 300 mg/kg b.wt and 750 mg/kg b.wt,
respectively. CONCLUSION: It was established that oral administration of lipid-based suspension of dry extract of Epimedium koreanum in wheat germ
oil improved erectile function of aged rats.

Interregional Center Adaptogen, 47/5 Piskarevsky pr., 195067 St.-Petersburg,
Russia.

E)

In this study, 25 healthy men (HM) and 13 men (VM) who used Viagra were assigned to initially receive daily therapy for 45 days with two capsules (808 mg x 2) of a commercially-prepared herbal complex of epimedium grandiflorum, maca pure (lepidium meyenii), mucuna pruriens, and polypodium vulgare . An additional four capsules (3232 mg) were taken one to two hours prior to sexual activity to determine its effect on sexual interest, sexual performance, and overall sexual satisfaction. After 45 days, the double-blind phase of the study began with a placebo product and active product randomly given to healthy men (HM) who had reported a positive response and taken for two weeks to four weeks. All subjects were evaluated after the first 45 days of treatment and finally after 60 days.
Results: 13 of 20 HM had a positive response to the herbal mixture and 6 of the 13 VM had a positive response to the herbal mixture. In the double-blind placebo portion of the study, no HM had a positive response to placebo product; 6 of the 7 HM had a positive response to the active product.
Conclusions: Daily use of the herbal complex for a minimum of 45 days resulted in an enhancement of sexual satisfaction in 60 percent of healthy male subjects and 45 percent of men using Viagra. The exact mechanism of action of the herbal mixture is unknown although it may have a testosterone-like effect.

http://www.mdidea.com/products/herbextract/icariin/data07.html


F)

In a study done by Steven Lamm, M.D, 38 men were administered 2 capsules (2 X 800mg) of herbal complex of epimedium grandiflorum, maca pure (lepidium meyenii), mucuna pruriens,and polypodium vulgare (in short, Horny Goat Weed) for 45 days:25 were healthy men and 13 were men already taking Vi agra. Another 4 capsules of Horny Goat Weed were taken 1 to 2 hours prior to sexual activities.
The study found 13 of 20 healthy men responded positively to Horny Goat Weed, and 6 of the 13 men already on Viagra also had a positive effect from using Horny Goat Weed. In most cases, the men reported overall improvement in sexual satisfaction and increase in sexual desires.

http://www.mdidea.com/products/herbextract/icariin/data07.html

G)

To clarify the mechanism of the therapeutic action of icariin on erectile dysfunction (ED). METHODS: PDE5 was isolated from the human platelet and PDE4 from the rat liver tissue using the FPLC system (Pharmacia, Milton Keynes, UK) and the Mono Q column. The inhibitory effects of icariin on PDE5 and PDE4 activities were investigated by the two-step radioisotope procedure with [(3)H]-cGMP/[(3)H]-cAMP. Papaverine served as the control drug. RESULTS: Icariin and papaverine showed dose-dependent inhibitory effects on PDE5 and PDE4 activities. The IC(50) of Icariin and papaverine on PDE5 were 0.432 micromol/L and 0.680 micromol/L, respectively and those on PDE4, 73.50 micromol/L and 3.07 micromol/L, respectively. The potencies of selectivity of icariin and papaverine on PDE5 (PDE4/PDE5 of IC(50)) were 167.67 times and 4.54 times, respectively. CONCLUSION: Icariin is a cGMP-specific PDE5 inhibitor that may be developed into an oral effective agent for the treatment of ED.

Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities.Xin ZC, Kim EK, Lin CS, Liu WJ, Tian L, Yuan YM, Fu J.
Department of Urology, the 1st Hospital, Peking University, 8 Xishiku Street, Xicheng District, Beijing 100034, China


Badania 3:

Icariin a - Antyoksydant , ochrona wątroby & działanie antyrakowe

A)

The aim of the present work was to explore the anti-hepatoma effects of icariin both in vitro and in vivo and to elucidate its potential mechanism of action. Icariin showed anticancer efficacy both in vitro and in vivo. The possible mechanism of action could be related to its anti-angiogenesis and anti-proliferative effects in tumors.

Am J Chin Med. 2009; Integrated Laboratory of TCM and Western Medicine of Peking University First Hospital and Integrated Institute of TCM and Western Medicine of Peking University, Beijing 100034, China.

B)

Icariin is a biological response modifier and differentiational agent. In order to further elucidate the reversion of malignant phenotypes of tumor cells and the mechanism of its action, highly metastatic human lung cancer cells (PG) were treated with Icariin in vitro. The results showed that icariin could influence the distribution of PG cells cycle and reduce S phase. Moreover, Icariin increased the level of cAMP in PG cells, reduced the level of cGMP and increased the cAMP/cGMP ratio. These data demonstrate that Icariin maybe a type of effective anticancer drug.

Zhong Yao Cai. 2000 Sep;23(9):554-6.


C)

Icariin is a major constituent of flavonoids derived from the Chinese medicinal herb Epimedium revicornum Maxim. The aim of the present study was to investigate whether icariin has protective effects on learning ability and memory in a rat model of chronic cerebral hypoperfusion. 2. Chronic cerebral hypoperfusion was induced by permanent ligation of the common carotid artery in Wistar rats for 4 months. One month after permanent artery occlusion, rats were adminitered icariin at doses of 0, 30, 60 or 120 mg/kg per day, p.o., for 3 months. Neurobehavioural and neurobiochemical parameters were examined to evaluate the effects of icariin on cognitive deficits induced by chronic cerebral hypoperfusion. 3. The Morris water maze test revealed that learning ability and memory were severely impaired in untreated rats, but were significantly improved in icariin-treated rats. Icariin treatment also ameliorated chronic cerebral hypoperfusion-induced oxidative stress in the brain, as evidenced by reduced malondialdehyde formation and maintained superoxide dismutase activity. In addition, the decreased hippocampal levels of acetylcholine, acetylcholinesterase and choline acetyltransferase associated with chronic cerebral hypoperfusion were significantly prevented by icariin treatment. 4. In conclusion, icariin protects against cognitive deficits induced by chronic cerebral hypoperfusion in rats. These effects appear to be mediated through its anti-oxidant effects, as well as its effects on the circulatory and cholinergic systems.

http://www.ncbi.nlm.nih.gov/pubmed/19215241

D)

1
The present study examined the protective effects of icariin against the learning and memory deficits in aluminium-treated rats and its potential mechanisms of action.
2
Qualified rats were treated with 1600 p.p.m. AlCl3 in drinking water for 8 months and the ability of spatial learning and memory was tested by the Morris water maze. In the place navigation test, aluminium administration significantly increased the mean escape latency and searching distance. In space probing test, aluminium markedly decreased the searching time and searching distance in the quadrant where the platform was originally located. All tests indicated deficits in rat spatial learning and memory induced by aluminium. Icariin treatment (60 and 120 mg/kg, by gavage for 3 months) dose-dependently protected against the development of aluminium-induced spatial learning and memory deficits.
3
To examine the mechanisms responsible for the protection afforded by icariin, the superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in the hippocampus were assayed biochemically and the level of Aβ1−40 in the hippocampus was determined immunohistochemically. Icariin treatment significantly increased SOD activity and decreased MDA and Aβ1−40 content in the hippocampus of aluminium-intoxicated rats.
4
In conclusion, the present study demonstrates that icariin is effective in improving the spatial learning and memory of aluminium-intoxicated rats. The mechanisms responsible appear to be due, at least in part, to an increased anti-oxidant capacity and decreased lipid peroxidation and Aβ1−40 levels in the rat hippocampus.

http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1681.2007.04647.x/abstract

E)

Icariin (2-(4′-methoxylphenyl)-3-rhamnosido-5-hydroxyl-7-glucosido-8-(3′-methyl-2-butylenyl)-4-chromanone) is a flavonoid with a rhamnose as ligand. It is the major component in Herba epimedii, widely used for the treatment of atherosclerosis and neuropathy in Chinese traditional medicine, and its antioxidative property has attracted much scientific interest. The major objective of this work is to determine the antioxidative effect of icariin against oxidative DNA damage induced by 2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH). The oxidative damage of DNA was followed by measuring the formation of carbonyl compounds that can react with thiobarbituric acid (TBA) to form thiobarbituric acid reactive substance (TBARS). We found that icariin protects DNA against AAPH-induced oxidative damage in a concentration-dependent manner, although it does not affect the rate of AAPH-induced DNA damage. This result indicates that icariin is a concentration-dependent chemopreventor in protecting DNA against radical-induced damage.

http://onlinelibrary.wiley.com/doi/10.1211/jpp.59.12.0016/abstract

F)

Icariin (2-(4′-methoxyl phenyl)-3-rhamnosido-5-hydroxyl-7-glucosido-8-(3′-methyl-2-butylenyl)-4-chromanone) is the major component in Herba Epimedii used in traditional Chinese medicine for the treatment of atherosclerosis. This work focuses on the antioxidative effect of icariin on free-radical-induced haemolysis of human erythrocytes, in which the initial free radical derives from the decomposition of 2,2′-azobis(2-amidinopropane hydrochloride) (AAPH) at physiological temperature. To reveal the structure-activity relationship of icariin, the antioxidant effects of two structural analogues of icariin, acacetin (2-(4′-methoxylphenyl)-5,7-dihydroxylchromone) and norwogonin (2-phenyl-5,7,8-trihydroxylchromone), on the same experimental system were examined as well. It was found that all these chromone derivatives (Chm-OHs) dose-dependently protected human erythrocytes against free-radical-induced haemolysis. The order of antioxidative activity was norwogonin>acacetin>icariin by the analysis of the relationship between the concentration of Chm-OHs and the prolongation percentage of the lag time of haemolysis (PP%). It was also proved that the phenyl hydroxyl group attached to the chromone ring at 7-position cannot trap the free radical. On the contrary, phenyl hydroxyl groups at the 5- and 8-position in norwogonin made it a significant antioxidant in AAPH-induced haemolysis. The more hydroxyl groups attached to the chromone ring, the higher the antioxidative activity in protecting erythrocytes against free-radical-induced peroxidation.

http://onlinelibrary.wiley.com/doi/10.1211/0022357044869/abstract


G)

In an attempt to identify compounds with antihepatotoxic activity, carbon tetrachloride-induced cytotoxicity in primary cultured rat hepatocytes has been adopted as a screening system. Using this screening system, an antihepatotoxic compound from the aerial parts of Epimedium koreanum has been isolated. This compound, icariin, is a flavonol glycoside. Its antihepatotoxic activity was first evaluated by measuring the release of glutamic pyruvic transaminase and sorbitol dehydrogenase from CCl4-intoxicated rat hepatocytes into the culture medium. Icariin significantly reduced the level of glutamic pyruvic transaminase and sorbitol dehydrogenase released resulting in a 76% protection from toxicity at concentration ranges from 1 microM to 20 microM. The antihepatotoxic activity of icariin was also estimated by the determination of total cytochrome P-450 content and glutathione-S-transferase activity in the CCl4-intoxicated hepatocytes.

http://www.ncbi.nlm.nih.gov/pubmed/8824946

H*)

Icaritin is a potent inhibitor of angiogenesis.
Endothelial cell tube formation in Matrigel is one measure of angiogenesis in vitro. The role of Icaritin in angiogenesis was assessed by determining the inhibition of HMVEC tube formation on Matrigel matrix plated onto 96-well plates. The HMVEC tube formation assay was performed as described previously. Briefly, 96-well plates were coated with 90 μL Matrigel (10 mg/mL, Collaborative Research) and incubated at 37° C. for 30 minutes to promote gelling. HMVECs (10,000 cells/sample) were resuspended in reduced growth medium (serum concentration 1% and 5 units/mL heparin) and added to each well with the indicated reagents in a final volume of 100 μL with different concentration of Icaritin. After 18 hours, the plates were fixed with Diff-Quik and at least four randomly selected fields per experimental condition were digitally recorded under bright-field illumination using a 10× objective. The mean additive length of all of the cords present in each optical field was measured using IPLab software and compared with controls using the Student's unpaired t test. The results showed that Icaritin completely inhibited the HMVEC tube formation at 10 uM. The EC50 of Icaritin to inhibit HMVEC tube formation was 5.8 uM.

We can make a conclusion that Icaritin is a potent inhibitor of angiogenesis that inhibits endothelial cell migration and tube formation.

http://www.faqs.org/patents/app/20080214844

Angiogeneza jest procesem regulowanym przez szereg czynników, aktywujących lub hamujących podziały komórek endotelialnych (ang. vascular endothelial cells). Zwykle poziom inhibitorów angiogenezy jest większy, hamując podziały komórek i wzrost naczyń.
Niestety angiogeneza jest także procesem, który umożliwia wzrost i rozwój nowotworów.

Ponieważ komórki nowotworowe, tak samo jak normalnie komórki, potrzebują do prawidłowego funkcjonowania tlenu oraz składników odżywczych, tworzenie naczyń krwionośnych wokół guza jest procesem warunkującym jego dalszy wzrost.
Czynnikiem ograniczającym jego rozwój oraz zdolność do metastazy jest angiogeneza.
Blokując proces angiogenezy można by było powstrzymać komórki nowotworowe przed dalszym wzrostem i metastazją (przeciwstawić się przerzutom).


Badania 4:

Icariin a - ESTROGEN

A)

W przypadku wielu produktów ICARIIN (ze wzgledu na swoje metabolity - glownie Icaritin i Desmethylicaritin) jest reklamowny jako typowy antyestrogen - lecz znalazlem takie badania:

Hormone replacement therapy (HRT) can ameliorate lipid metabolism after menopause, but it is not suitable for long-term use because of serious side effects. Herba Epimedii is a widely used herbal medicine in many Asian countries, it potentially treats menopausal syndrome and its complications with few side effects and good curative effects. The study aimed to evaluate the effects of Herba Epimedii water extract on blood lipid and sex hormone levels. Ninety subjects were randomly divided into two groups: a trial group which received Herba Epimedii water extract and a control group which was administered an equal amount of water placebo. At the baseline and after 6 months of medication, serum estradiol (E2), progesterone (P), testosterone (T), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) concentrations were measured. The results indicated that Herba Epimedii water extract decreased the TC and TG levels (p < 0.01). Furthermore, Herba Epimedii water extract significantly increased the serum level of E2 (p < 0.01) compared with the pre-treatment level. In conclusion, Herba Epimedii water extract produces its beneficial actions in postmenopausal women. Copyright &#169; 2008 John Wiley & Sons, Ltd.

Spadl cholesterol
Spadl poziom trójglicerydow
ale
podniosl sie poziom ESTRADIOLU!

http://onlinelibrary.wiley.com/doi/10.1002/ptr.2451/abstract



Śmiało można napisac ze &#8216;ICARIIN&#8217; miedzy innymi jest::
-inhibitorem 5-fosfodiesterazy (PDE-5) - pomaga w leczeniu zaburzeń erekcji
-stymulatorem libido &#8211; afrodyzjakiem
-podnosi poziom testosteronu

Ponadto ma szereg wlasciwosci prozdrowotnych:
-jest silnym antyoksydantem
-chroni wątrobę przed uszkodzeniami
-jest inhibotorem angiogenezy
-działa adaptogennie &#8211; pomaga zwalczac stres

-...i mediatorem w powstawaniu tlenku azotu - wiec tez czesto dodawany jako kolejny booster NO (wieksza pompa na treningu)


Gdzie mozna go znalezc:
DS-Activate Xtreme
Competitive Edge Labs-PCT Assist
AI Sports-Stoked
AI Sports-Post Cycle Support
Purus Labs-Recycle
MAN-Primal Male
APS-Phenadrine
Applied Nutriceuticals - RPM
NRG-X Labs - Alpha MaXX Black Label
Biotivia -Bio Forge
Nutrabolics - Hemotest
Applied Nutriceuticals - Drive
Palo Alto Labs - Aspire 36 Plus
NuCare - Nu-Test
EST - TEST DRIVE
iSatori - ISA-TEST GF

Horny Goat Weed - rozni producenci

Dawkowanie:
średnie dawki w w.w. suplementach wynosza
ok.500mg Epimedium -> gdzie 40% Icariin


Zmieniony przez - solaros w dniu 2010-09-13 03:10:43

bralem kiedys na polepszenie libido i fakt dzialalo, ale czy podnosi tescia?? nie wiem ale fajnie by bylo

jasnych wynikow nie ma - ile i jakie dawki jak podnosza
sa przeslanki aby sadzic ze podnosi poziom tescia poprzez podniesienie poziomu LH - miedzy innymi

chyba sa dwa badania tylko które mowia o podniesionym poziomie tescia - inne badania odwoluja sie wlasnie do tych wynikow
badania A,B i C - w BADANIACH nr.1

ale - jest mnostwo badan które pokazuja ze dziala wspaniale na libido i sam akt (szyciej sie podnieca,pozniej konczy,dluzej trwa rozkosz)

Tak samo jest udokumentowane ze jest - moze nie rewelacyjnym - ale bardzo dobrym antyoksydantem,nie wpominajac o inhibitorze angiogenezy (ale to inna bajka).

Tak wiec wlasciwosci pozadanych ma wiele.


Zmieniony przez - solaros w dniu 2010-09-15 02:31:03

BOOSTERY TESTOSTERONU:(c.d)

4)

Mucuna Pruriens - ŚWIERZBIEC WŁASCIWY (inaczej zwany aksamitne ziarno)

Gatunek rośliny z rodziny bobowatych. Pochodzi z Azji Wschodniej, Moluków i Filipin. Obecnie rozprzestrzenił się w całej strefie tropikalnej i występuje tu zarówno jako zdziczały, jak i roślina uprawiana.





Jej nasiona zawierają będący neurotransmiterem związek organiczny L-DOPA,która jest prekursorem dopaminy, powodującym zwiększenie stężenia tego neuroprzekaźnika w mózgu.

Jest metabolitem pośrednim w szlaku syntezy adrenaliny.
L-DOPA podnosi poziom testosteronu oraz zwiększa syntezę i sekrecję hormonu wzrostu





Sama dopamina to neuroprzekaźnik syntezowany i uwalniany przez neurony ośrodkowego układu nerwowego. Odgrywa różną rolę w zależności od miejsca swego działania:
a) w układzie pozapiramidowym jest odpowiedzialna za napęd ruchowy, koordynację oraz napięcie mięśni. Niedobór dopaminy w tym układzie objawia się chorobą Parkinsona (drżaczka poraźna), nadmiar zaś - pląsawicą Huntingtona.
b) w układzie rąbkowym (limbicznym) jest odpowiedzialna za procesy emocjonalne, wyższe czynności psychiczne oraz w znacznie mniejszym stopniu procesy ruchowe.
c) w podwzgórzu jest związany głównie z regulacją wydzielania hormonów, a szczególnie prolaktyny i gonadotropin.





Dopamina nazywana jest również "hormonem szczęścia", gdyż pojawienie się jej w przestrzeniach między neuronami w jądrze półleżącym, zewnętrznie objawia się poczuciem euforii.
Dopamina daje jakby kopa, taką energetyzującą euforię ( główne działanie kokainy polega na zwiększaniu ilości dopaminy w mózgu ).

Mucuna Pruriens swietnie obniza poziom prolaktyny poprzez zwiekszenie poziomu dopaminy która jest antagonista prolaktyny

Co ciekawe to to ze:
ejakulacja (orgazm) powoduje silne zmiany hormonalne, które trwają ok 2 dni. podczas orgazmu wyczerpaniu w znacznym stopniu ulega dopamina, a wzrasta prolaktyna. są to dwie substancje antagonistyczne (zwalczające się).
Neuroprzekaźnik dopamina utrzymuje się na obniżonym poziomie (za sprawą prolaktyny) jeszcze przez długi czas (do 2 tyg.) po orgazmie. Jest to prawdopodobnie jeden z istotniejszych mechanizmów odpowiadających za zaspokojenie seksualne.




Dalej:
Poziom prolaktyny jest bezpośrednio związany z poziomem estrogenu, kiedy jeden z nich wzrasta, wzrasta także drugi. Czym niższy poziom prolaktyny, a tym samym estrogenu, tym większy poziom LH/testosteronu a tym samym zwiększony popęd płciowy.

I koło się zamyka&#8230;&#8230;&#8230;&#8230;..







L-dopa jest szybko wchłaniana po podaniu doustnym; po 30 min do 2 h jej stężenie w surowicy osiąga szczyt. Okres półtrwania wynosi 1 -3 h. Wchłanianie L-dopy może być znacznie zmniej­szone przez zmiany w pH żołądka i po posiłkach


Badania 1:

Mucuna pruriens &#8211; Testosteron,LH,prolaktyna


A)

PATIENT(S): Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening.

MAIN OUTCOME MEASURE(S): Before and after treatment, serum T, LH, FSH, PRL, dopamine, adrenaline, and noradrenaline in seminal and blood plasma were measured.

RESULT(S): Decreased sperm count and motility were seen in infertile subjects. Serum T and LH levels, as well as seminal plasma and blood levels of dopamine, adrenaline, and noradrenaline were also decreased in all groups of infertile men. This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects. Treatment with M. pruriens significantly improved T, LH, dopamine, adrenaline, and noradrenaline levels in infertile men and reduced levels of FSH and PRL. Sperm count and motility were significantly recovered in infertile men after treatment.

http://www.ncbi.nlm.nih.gov/pubmed/18973898


B)

The table below shows the effect of the extract on hormone secretion in the men with oligozoospermia. Note also the prolactin level. Prolactin is another hormone made in the pituitary, but production of this increases if the body starts to produce less testosterone.





The Mucuna pruriens extract also increased testosterone levels in the healthy men, as the table below shows.






C)

L-DOPA, within 30 min after administration, induced a highly significant decrease of plasma prolactin levels (phase 1) in a number of groups of rats, differing in age and/or endocrine status, apparently by direct inhibition of prolactin release from the pituitary. Three hours after administration of L-DOPA these low plasma prolactin concentrations in treated animals had increased (phase 2) and did not differ significantly from levels in control animals, indicating that the effect of L-DOPA on plasma prolactin levels is only of short duration. During this process some interesting phenomena were observed, especially in the animals treated with oestrone. The elimination rate of prolactin from plasma was very high (t = 2&#8226;8 min), as indicated by decreasing concentrations of the hormone during phase 1. Pituitary prolactin content did not change during phase 1, suggesting that prolactin synthesis was also stopped. Notwithstanding the high elimination rate, plasma prolactin regained initial concentrations in phase 2, suggesting release of a substantial part of the pituitary prolactin content. The latter, however, remained constant during the whole experiment (i.e. before L-DOPA administration and during phase 1 as well as phase 2).

The results suggested another working mechanism of L-DOPA in decreasing plasma prolactin levels, namely by stimulating the uptake of this hormone in the periphery. After the effect of L-DOPA had ceased, most of the prolactin from the periphery returned into the bloodstream, causing a rapid restoration of plasma prolactin levels without substantial release from the pituitary. The nature of the processes responsible for the peripheral uptake of prolactin is discussed.

http://joe.endocrinology-journals.org/cgi/content/abstract/68/3/369

D)

In 15 psychiatric patients, Mucuna pruriens 15 gm of crude seed powder was found to drastically inhibit the prolactin response to chlorpromazine injection, as effectively as 0.5 g of L-dopa). No side or harmful effects were observed in those patients.

Vaidya, R. A., Neurology (India), 1978, 26, 177


E)

Research cited in the patent indicated that the high levels of L-dopa in mucuna seed were converted to dopamine, which stimulated the release of growth hormone by the pituitary gland.
L-dopa and dopamine are also effective inhibitors of prolactin. Prolactin is a hormone released by the pituitary gland; increased levels are considered to cause erection failure in males. In one study, oral intake of the seeds in fifty-six human males was able to improve erection, duration of coitus, and post-coital satisfaction after only four weeks of treatment."
Leslie Taylor, ND, The Healing Power of Rainforest Herbs: A Guide to Understanding and Using Herbal Medicinals


F)

With its documented ability to increase testosterone and stimulate growth hormone (thereby increasing muscle mass), several companies have launched new products using mucuna beans, including several which are standardized to the L-dopa content. It is also showing up as an ingredient in various weight loss, libido, brain/ memory, anti-aging, and body builder formulas. Consumers should be aware however, altering the levels of brain chemicals like dopamine and serotonin also affect many other hormones, enzymes, and other chemicals that keep the body in balance."

Leslie Taylor, ND, The Healing Power of Rainforest Herbs: A Guide to Understanding and Using Herbal



Badania 2 :

Mucuna pruriens &#8211; Stres, kortyzol


A)

The prospective study included four parallel groups of subjects: The control group comprised of 60 age-matched healthy men who had previously initiated at least one pregnancy and exhibited a normal semen profile (>20 x 106 spermatozoa ml&#8211;1; >40% motility and >40% normal morphology). Moreover, control subjects were also not under stress, as evidenced by the study questionnaire and normal serum cortisol level.

The study group comprised of 60 subjects who were under psychological stress (as assessed by the study questionnaire and on the basis of elevated serum cortisol levels). Study subjects were further divided into three subgroups on the basis of semen profiles and in each subgroup a minimum of 20 patients were included. These groups were (i) normozoospermic infertile men, defined as control group (ii), oligozoospermic infertile men (<20 x 106, spermatozoa ml&#8211;1, motility >40% and >40% normal morphology) and (iii) asthenozoospermic infertile men (>20 x 106 spermatozoa ml&#8211;1, <40% motility and >40% normal morphology).

Results:
Stress scores, elaborated on the basis of the questionnaire, were found significantly high in infertile subjects (Table 1). Similarly, the morning serum cortisol levels were found elevated in normozoospermic (+38%; P < 0.01), oligozoospermic (+110%; P < 0.01) and asthenozoospermic (+171%; P < 0.01) infertile men as compared with control subjects (10.2 &#177; 0.2 &#181;g dl&#8211;1). After treatment with M. pruriens, serum cortisol levels were decreased in normozoospermic (&#8211;25%; P < 0.001), oligozoospermic (&#8211;81%; P < 0.001) and asthenozoospermic (&#8211;55%; P < 0.001) patients. Moreover, the mean serum cortisol levels observed at 1600 h, in control group were 5.5 &#177; 0.6 g dl&#8211;1. But these levels in normozoospermic (99%; P < 0.01), oligozoospermic (162%; P < 0.01) and asthenozoospermic (231%; P < 0.01) were found to be increased. After treatment with M. pruriens, significant reversal of serum cortisol levels in normozoospermic (40%; P < 0.001), oligozoospermic (46%; P < 0.001) and asthenozoospermic (49%; P < 0.001) was observed. The intra and inter assay variances of serum cortisol were <6% and <10%, respectively, which was found to be highly significant.




http://ecam.oxfordjournals.org/cgi/content/full/7/1/137

B)

"In another study, 32 cases of depressive neurosis were treated with mucuna pruriens (6 g once a day) along with Withania somnifera powder (10 g once a day). Results were quite encouraging: inital scores of nervousness, insomnia, irritability and depressive index were 2.62 &#177; 0.49, 2.39 &#177; 0.50, 2.52 &#177; 0.66 and 12.56 &#177; 3.17; after one month of treatment 0.87 &#177; 0.38, 0.71 &#177; 0.21, 0.65 &#177; 0.38 and 6.61 &#177; 2.13 respectively were recorded. Significant reduction in the degree of clinical anxiety and depression was observed."

C. P. Khare, Indian Herbal Remedies: Rational Western Therapy, Ayurvedic and Other Traditional Usage, Botany

C)

The present investigation was undertaken to assess the role of Mucuna pruriens in infertile men who were under psychological stress. Study included 60 subjects who were undergoing infertility screening and were found to be suffering from psychological stress, assessed on the basis of a questionnaire and elevated serum cortisol levels. Age-matched 60 healthy men having normal semen parameters and who had previously initiated at least one pregnancy were included as controls. Infertile subjects were administered with M. pruriens seed powder 5 g day orally. There was decreased sperm count and motility in subjects who were under psychological stress. Moreover, serum cortisol and seminal plasma lipid peroxide levels were also found elevated along with decreased seminal plasma glutathione (GSH) and ascorbic acid contents and reduced superoxide dismutase (SOD) and catalase activity.
Treatment with M. pruriens significantly ameliorated psychological stress and seminal plasma lipid peroxide levels along with improved sperm count and motility. Treatment also restored the levels of SOD, catalase, GSH and ascorbic acid in seminal plasma of infertile men. On the basis of results of the present study, it may be concluded that M. pruriens not only reactivates the anti-oxidant defense system of infertile men but it also helps in the management of stress and improves semen quality.

Evid Based Complement Alternat Med. 2007 Dec 18. Shukla KK, Mahdi AA, Ahmad MK, Jaiswar SP, Shankwar SN, Tiwari SC. Department of Biochemistry, King George's Medical University, Lucknow 226003, India.


Badania 3:

Mucuna pruriens &#8211; Libido, Afrodyzjak,Sperma

A)

Mucuna pruriens can improve sexual behavior, libido, and performance. In an aphrodisiac study done at College of Pharmaceutical Sciences, Manipal, Mucuna Pruriens when administered in a dose of 75 mg/kg body weight daily, increased the sexual activity of male albino rats considerably by stimulating testosterone level. A ten fold increase in the mounting frequency was observed. The research shows that sexually active animals had increased sexual desire and improved sexual performance after 21 to 28 days. However, impotent animals did not derived any benefits.

http://www.xtremebodybuilding.net/supplement-wars/3923-mucuna-pruriens-aphrodisiac-effects.html


B)

Mucuna Pruriens heightened arousal and increased sexual activity to a moderate extent but also sustains it for a longer time as indicated by the increase in below Ejaculation Latency and decrease in Post Ejaculatory Interval. Mucuna Prueins is shown to possess central depressant activity. The delay in ejaculation could be due to toning down of hypersensitity of genitals and hyperexcitation of the regulatory centers. This study show that Mucuna Pruriens can be used to improve libido and delay premature ejaculation.

http://www.xtremebodybuilding.net/supplement-wars/3923-mucuna-pruriens-aphrodisiac-effects.html


C)

OBJECTIVE: To investigate the impact of Mucuna pruriens seeds on semen profiles and biochemical levels in seminal plasma of infertile men.

PATIENT(S): Sixty normal healthy fertile men (controls) and 60 men undergoing infertility screening.

RESULT(S): Treatment with M. pruriens significantly inhibited lipid peroxidation, elevated spermatogenesis, and improved sperm motility. Treatment also recovered the levels of total lipids, triglycerides, cholesterol, phospholipids, and vitamin A, C, and E and corrected fructose in seminal plasma of infertile men.

http://www.ncbi.nlm.nih.gov/pubmed/18001713

D)

Researchers at the University of Lucknow in India have come to this conclusion after doing tests with 75 healthy men and 75 men who were unable to have children. The men were all aged between 25 and 40, and were given 5 g a day of dried and ground Mucuna powder every day for three months.


The supplement improved the quantity and quality of the men&#8217;s semen. Among the healthy men there was little room for improvement, so the effect was also small. But among the men with a low sperm count (oligozoospermia is the scientific term) the effect was more noticeable.






E)

According to Indian Systems of Medicine, Mucuna pruriens was used for treating male sexual disorders since ancient times. In this study, the effects extracts of the Mucuna pruriens seed on general mating behaviour, libido and potency of normal male Wister albino rats were investigated and also compared with the standard reference drug, Sildenafil citrate. Animals were fed PO with saline or extract or standard drug once a day for 45 days. The extract administered PO significantly increased the mounting frequency, intromission frequency and ejaculation latency, and decreased the mounting latency, intromission latency, post-ejaculatory interval and inter-intromission interval.
The potency test significantly increased erections, quick flips, long flips and total reflex. Therefore, the results indicated that extracts of Mucuna pruriens seed produced a significant and sustained increase in the sexual activity of normal male rats. The resulting aphrodisiac activity of the extract lends support to the claim that it has traditionally been used for the treatment of sexual disorders.

Ethnopharmacol. 2009 Apr 21; Suresh S, Prithiviraj E, Prakash S. Department of Anatomy, Dr Arcot Lakshmanasamy Mudaliar Postgraduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India.

F)

To investigate the impact of mucuna pruriens seeds on semen profiles and biochemical levels in seminal plasma of infertile men. Sixty normal healthy fertile men (controls) and 60 men undergoing infertility screening. Before and after the treatment, seminal plasma lipid profile, lipid peroxide, fructose, and antioxidant vitamin levels were measured.
Treatment with mucuna pruriens significantly inhibited lipid peroxidation, elevated spermatogenesis, and improved sperm motility. Treatment also recovered the levels of total lipids, triglycerides, cholesterol, phospholipids, and vitamin A, C, and E and corrected fructose in seminal plasma of infertile men. Treatment with mucuna pruriens increased sperm concentration and motility in all the infertile study groups. Oligozoospermic patients recovered sperm concentration significantly, but sperm motility was not restored to normal levels in asthenozoospermic men. The present study is likely to open new vistas on the possible role of mucuna pruriens seed powder as a restorative and invigorating agent for infertile men.

Fertil Steril. 2007 Nov 12. Ahmad MK, Mahdi AA, Shukla KK, Islam N, Jaiswar SP, Ahmad S. Departments of Biochemistry and Obstetrics and Gynecology, King George's Medical University, Lucknow, India.


Badania 4:

Mucuna pruriens &#8211; Antyoksydant

A)

The prospective study included four parallel groups of subjects: The control group comprised of 60 age-matched healthy men who had previously initiated at least one pregnancy and exhibited a normal semen profile (>20 x 106 spermatozoa ml&#8211;1; >40% motility and >40% normal morphology). Moreover, control subjects were also not under stress, as evidenced by the study questionnaire and normal serum cortisol level.

The study group comprised of 60 subjects who were under psychological stress (as assessed by the study questionnaire and on the basis of elevated serum cortisol levels). Study subjects were further divided into three subgroups on the basis of semen profiles and in each subgroup a minimum of 20 patients were included. These groups were (i) normozoospermic infertile men, defined as control group (ii), oligozoospermic infertile men (<20 x 106, spermatozoa ml&#8211;1, motility >40% and >40% normal morphology) and (iii) asthenozoospermic infertile men (>20 x 106 spermatozoa ml&#8211;1, <40% motility and >40% normal morphology).

Results:
The lipid peroxide level in seminal plasma of control healthy men was 2.2 &#177; 0.3 nmol MDA ml&#8211;1. On the other hand, it was found increased in &#8216;under stress&#8217; normozoospermic (+55%; P < 0.01), oligozoospermic (+48%; P < 0.01) and asthenozoospermic (+49%; P < 0.01) subjects (Table 2).
After treatment with M. pruriens, the levels of lipid peroxides were reversed significantly in normozoospermic (&#8211;34%: P < 0.001), oligozoospermic (&#8211;27%; P < 0.001) and asthenozoospermic men (&#8211;28%; P < 0.001). We also observed that SOD activity in seminal plasma of control group was 8.1 &#177; 0.5 unitmg&#8211;1 protein. However, this enzyme was found significantly suppressed in different groups of infertile men, who were under stress; such as normozoospermic (&#8211;19%; P < 0.001), oligozoospermic (&#8211;33%; P < 0.001) and asthenozoospermic (&#8211;29%; P < 0.001).
Treatment with M. pruriens increased the activity of SOD in normozoospermic (+3%; P < 0.01), oligozoospermic (+33%; P < 0.01) and asthenozoospermic (+18%; P < 0.01) men. Similarly, catalase activity in seminal plasma of &#8216;under stress&#8217; asthenozoospermic men was found significantly reduced (&#8211;30%; P < 0.05), as compared with healthy fertile men. Treatment with M. pruriens enhanced the activity of the aforementioned enzyme in all the infertile men.

Ascorbic acid levels in seminal plasma of control group were 2.3 &#177; 0.2 mg dl&#8211;1. On the other hand, these levels were found decreased in different groups of infertile men who were under stress, i.e-normozoospermic (&#8211;9%; P < 0.01), oligozoospermic (&#8211;23%; P < 0.01) and asthenozoospermic (&#8211;36%; P < 0.01). After treatment with M. pruriens the levels of ascorbic acid were found increased in normozoospermic (+11%; P < 0.5), oligozoospermic (+33%; P < 0.01) and asthenozoospermic (+36%; P < 0.01) men (Table 2). Similarly, GSH content in seminal plasma of under stress normozoospermic (&#8211;13%; P > 0.05), oligozoospermic (&#8211;20%; P > 0.05) and asthenozoospermic (&#8211;47%; P < 0.05) infertile men was found decreased as compared with control group. Treatment with the drug restored the levels of GSH in normozoospermic (+19%; P < 0.05), oligozoospermic (+18%; P < 0.05) and asthenozoospermic (+22%; P < 0.05) men.




Lipid Peroxide - Peroksydacja lipidów jest procesem stale zachodzącym w warunkach fizjologicznych i polegającym na utlenianiu wielonienasyconych kwasów tłuszczowych, będących podstawowymi składnikami błon biologicznych
Wolne rodniki tlenowe wykazują toksyczne działanie na lipidy błon komórkowych, powodując ich peroksydację.

Zespoły enzymów usuwających -wolne rodniki:
SUPEROXIDE DISMUTASE - dysmutaza ponadtlenkowa -
jest kluczowym enzymem bariery antyoksydacyjnej organizmu.
Dysmutaza ponadtlenkowa to enzym, który neutralizuje rodnik ponadtlenkowy. Jest to ważny antyoksydant, który przerywa i zatrzymuje łańcuchową reakcję powstawania uszkodzeń spowodowanych przez wolne rodniki. Enzym ten izoluje ponadtlenek i wytwarza nadtlenek wodoru i tlen. Chociaż nadtlenek wodoru jest znacznie słabszy od rodnika ponadtlenkowego, jest nadal niebezpieczny. Do usunięcia cząsteczki nadtlenku wodoru dysmutaza ponadtlenkowa wymaga enzymu katalazy.

Catalase - Katalaza występuje obficie w krwinkach czerwonych człowieka i wspomaga usuwanie nadtlenku wodoru z tkanek naszego organizmu. Zapobiega to powstawaniu dalszych, bardziej toksycznych wolnych rodników.
Mówiąc jak najprościej, katalaza jest to enzym, który zamienia nadtlenek wodoru w wodę.

Ascorbic acid - kwas askorbinowy &#8211; Wit.C

Glutatione-Glutation (GSH) &#8216;najważniejszy&#8217; antyoksydant, który neutralizuje wyprodukowane wolne rodniki - jest stawiany przez wszystkich wybitnych specjalistów w zakresie dietetyki na piedestale.

http://ecam.oxfordjournals.org/cgi/content/full/7/1/137


B)

research published on Phytotherapy Research. 2002, in vitro studies with alcohol extract of Mucuna pruriens showed no change on the rate of aerial oxidation of GSH content but it significantly inhibited FeSO(4) induced lipid peroxidation. It also inhibited the specific chemical reactions induced by superoxides and hydroxyl radicals. An in vivo study on albino rats for 30 days showed no toxic effect up to a dose of 600 mg/kg body weight, on oral administration. There was no change in the level of TBA-reactive substances, reduced glutathione content and SOD activity in the liver. The activity of serum GOT, GPT and alkaline phosphatase was also unchanged. Thus it could be concluded that the alcohol extract of the seeds of M. pruriens has an anti-lipid peroxidation property, which is mediated through the removal of superoxides and hydroxyl radicals.

http://www.xtremebodybuilding.net/supplement-wars/3923-mucuna-pruriens-aphrodisiac-effects.html



Inne badania:


-> Podnosi ilosc trombocytów (plytek krwi) &#8211; które sa odpowiedzialne za krzepniecie krwi.





->Obniza poziom cholesterolu, obniza poziom kreatyniny, obniza poziom mocznika




http://www.academicjournals.org/jmpr/PDF/pdf2009/Feb/Adepoju and Odubena.pdf

->Obniza poziom glukozy

Early pharmacological studies, published in 1927 and 1930 respectively, proved (in the rabbit) that L-dopa exerted significant effects on glucose metabolism (causing marked hyperglycemia) and on arterial blood pressure. Powdered Mucuna Pruriens seeds (contains 3-4% L Dopa) were given to normal and diabetic rabbits. In normal group 0.5, 1 and 2 g/kg of M. Pruriens significantly decreased the blood glucose levels while in diabetic rabbits only 1 and 2 g/kg body weight caused a significant fall. High levels of trace elements like manganese, zinc, and others were found in these seeds. Therefore, it is conceivable that M. Pruriens seeds contain hypoglycemic principles, may be both organic and mineral, which seem to act indirectly by stimulating the release of insulin and/or by a direct insulin-like action.

->Choroba Parkinsona

A)
W latach 50., gdy rozpoczął swoje prace, dopamina nie była jeszcze uważana za jeden z najważniejszych neuroprzekaźników przenoszących informacje chemiczne pomiędzy neuronami. Sądzono, że jest zaledwie prekursorem, substancją, z której powstaje inny przekaźnik - noradrenalina. Carlsson znalazł wówczas sposób na precyzyjne zmierzenie ilości dopaminy w różnych obszarach mózgu. Okazało się, że jest jej dużo wcale nie w tych rejonach, w których występuje noradrenalina. Dopamina znajdowała się przede wszystkim w obszarach odpowiedzialnych za kontrolę ruchu. Miała więc osobną, niezależną od noradrenaliny funkcję do spełnienia. Następnie szwedzki badacz zaaplikował im L-dopę, środek, z którego w mózgu powstaje dopamina. Wówczas zaobserwował powrót prawidłowej regulacji czynności ruchowych. W wyniku tych doświadczeń Arvid Carlsson odkrył lek na chorobę Parkinsona, której symptomy - drżenie kończyn i głowy, sztywność mięśni i konwulsyjne ruchy - są podobne do objawów, jakie sztucznie wywołał u zwierząt, niszcząc w ich mózgach zapasy dopaminy. L-dopa, podawana cierpiącym na chorobę Parkinsona, uzupełnia braki dopaminy w ich mózgach, ułatwia przepływ sygnałów między neuronami i w pewnym stopniu łagodzi zaburzenia ruchu.

B)
Herbs that may be helpful In preliminary research, an extract of mucuna prurient (HP-200) was studied in people with Parkinson's disease, 43% of whom were taking Sinemet before HP-200 treatment; the remaining 57% were not medicated.59 Statistically significant reductions in symptom scores were seen from the beginning to the end of the 12-week trial. The amount used in the trial was 7.5 grams of the extract (dissolved in water) three to six times daily."

Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D., The Natural Pharmacy: Complete A-Z Reference to Natural Treatments for Common Health Conditions

C)
Following treatment with l-dopa, Parkinson's disease patients had very high amounts of colored deposits in a specific area of the brain (Sulzer et al. 2000) when compared to Parkinson's disease patients who were not treated with l-dopa. In addition, other oxidized substances, particularly lipids and proteins, accumulate in the cells, including nerve cells. In the skin, accumulations of oxidation products are referred to as "age spots" or "liver spots" (Herrera et al. 1990). Such age pigments are composed of lipofuscin, ceroid, and amyloid

Kubo et al. 1990; Yasuma et al. 1992; Tominaga et al."


Mucuna pruriens powoduje:
-Wydzielanie wiekszej ilosci testosteronu
-Podnosi poziom LH
-Zwiekszenie libido
-Szybszą erekcja

Ale m.in. również:
-Obniza poziom prolaktyny
-Obniza poziom kortyzolu
-obniża poziom cholesterolu LDL
-ma własciwości antyoksydacyjne
-obniża poziom cukru w krwi


W jakich suplementach wystepuje Mucuna pruriens:
Applied Nutriceuticals - HGH Up
Applied Nutriceuticals - IGF-2
Applied Nutriceuticals - Lipotrophin-AM
ASN - Phytobol
BioRhythm - ReGenerate
Controlled Labs - Blue GrowtH
Dymatize - Z-Force
NOW - DOPA Mucuna
Pharmaceutical Alternatives - TestoRx
SciFit - GHT Stack
STS - Triple Force Test Charger Caps
Universal - Animal Stak
Universal - GH Stack


Dawkowanie:
800mg Mucuna pruriens
Przy 25% l-dopa - srednio 100mg-300mg l-dopa

DZIAŁANIA NIEPOŻĄDANE
Objawy uboczne w czasie terapii L-dopą są częste. Większość działań ubocznych jest związanych z wielkością dawki lub odstawieniem leku. We wczesnej fazie leczenia obserwuje się nudności, wymioty i zaburzenia rytmu serca. Podczas przewlekłego leczenia niekiedy pojawiają się ruchy mimowolne i zaburzenia psychiczne. L-dopa może nasilić lub wywoływać objawy psychotyczne. U ok. 12% pacjentów leczonych tym lekiem występuje mania.

Ponadto:
-Nie powinno sie przyjmowac L-dopy i wit. B6 w tym samym czasie
-Podczas suplementacji L-dopy powinna byc stosowana dieta nisko bialkowa gdyz lepiej dziala na dietach wysokoweglowodanowych
-witamina C potęguje dzialanie l-dopy (lub polecana dla osob które zle toleruja suplementacje MP lub samo L-dopa)[s/]


Zmieniony przez - solaros w dniu 2010-09-16 03:39:35

BOOSTERY TESTOSTERONU: (c.d)

5)


Coleus forskohlii -> Forskolin (pokrzywa indyjska)

Pokrzywa indyjska, zwana również pochwiatką, pokrzywką, szałwią indyjską lub koleusem, czyli Coleus forskohlii jest rośliną wieloletnią rosnącą w rejonach subtropikalnego oraz ciepłego, umiarkowanego klimatu niektórych obszarów Indii, Nepalu, Sri Lanki, Birmy, Tajlandii oraz innych krajów Azji Południowo-Wschodniej.





Ekstrakt z korzenia pokrzywy indyjskiej stosowany był od stuleci w tradycyjnej medycynie hinduskiej, ayurvedzie, jako guggul do leczenia nadciśnienia tętniczego, zastoinowej niewydolności serca, wyprysków, kolki, zaburzeń układu oddechowego, przy bolesnym oddawaniu moczu (stanach zapalnych pęcherza moczowego), bezsenności, drgawkach, skurczach żołądka, zapobieganiu astmie, wzmacnianiu serca i całego organizmu oraz jako środek ułatwiający odchudzanie. Również kuchnia indyjska w szerokim zakresie wykorzystywała Coleus jak doskonałą przyprawę.
Badania naukowe rozpoczęte na szeroką skalę w 1974 r. (zwłaszcza w Hinduskim Centralnym Instytucie Naukowo-Badawczym) wykazały, że o zdolnościach terapeutycznych rośliny decydują przede wszystkim zawarte w nich związki diterpenowe &#8211; acetoxycoleosol, barbutazyna (barbatusin), coleol, coleonon, coleanol, deoxycoleonol, dialdehydy, krocetyna, napthopiron, plektryna, plektirinon, secoabietan. Dopiero po dokładnej identyfikacji i wyodrębnieniu zasadniczej substancji czynnej nazwano ją forskolinem (forskoliną) &#8211; na cześć fińskiego botanika Petera Forskala (1736-1763).

Forskolin jest odpowiedzialny za prawie wszystkie działania farmakologiczne Coleus forskohlii.

Otóż w pierwszym rzędzie wpływa on na wzrost produkcji AC &#8211; enzymu zwanego cyklazą adenylową (adenylocyklazą), związanego z błonami komórkowymi. Jest on rodzajem enzymu nadrzędnego stymulującego inne enzymy do regulowania wzrostu masy mięśniowej oraz inicjowania procesów utraty tłuszczu. Przekształca kwas adenozynotrójfosforowy (ATP) w cAMP &#8211; Cykliczny Monofosforan Adenozyny, który jest najważniejszym regulatorem organizmu odpowiedzialnym za intensyfikację rozpadu tłuszczów w komórkach tłuszczowych. Związek ten zapewnia przyspieszony transport tłuszczu do komórek mięśniowych w celu jego spalenia.

Forskolin zwiększa produkcję cAMP, dochodzi do stymulacji syntezy białek, co wpływa na rozwój masy mięśniowej!
W wyniku dalszych procesów następuje uwalnianie kwasów tłuszczowych z komórek tkanki tłuszczowej. W efekcie komórki mięśniowe mogą w łatwy sposób zużyć tłuszcz &#8211; zasadnicze w tym przypadku źródło energii &#8211; jako paliwo &#8211; i przekształcić go w energię w postaci ATP w procesie termogenezy. Celem tego procesu jest wytworzenie ciepła z ATP dla utrzymania stałej temperatury ciała. Pozwala to na włączenie do procesu spalania znacznych zapasów tłuszczu stanowiącego paliwo dla pracujących mięśni. Jest to szczególnie istotne zwłaszcza dla osób otyłych, które zwykle mają obniżony poziom cAMP.
Działanie terapeutyczne forskoliny oparte jest więc przede wszystkim o silną stymulację produkcji cAMP &#8211; Cyklicznego Monofosforanu Adenozyny we wszystkich komórkach organizmu &#8211; oprócz plemników.





Forskolin wpływa również na działanie hormonów tarczycy, dzięki czemu odznacza się funkcją regulującą metabolizm organizmu. Hormony tarczycowe wpływają w sposób zasadniczy na przemianę materii oraz aktywność psychomotoryczną, czyli na ogólną sprawność całego organizmu. Im lepiej działa tarczyca, tym więcej tłuszczu można spalić i zamienić go na użyteczną energię.

Forskolin najprawdopodobniej zwiększa także produkcję hormonu wzrostu GH (ang. Growth Hormone). Wpływa on m.in. na gospodarkę węglowodanową poprzez pobudzanie procesu rozkładu glikogenu i zwiększone uwalnianie glukozy z wątroby. Powoduje również zwiększone wydzielanie insuliny oraz aktywuje proces spalania tłuszczów dezaktywując proces tworzenia tłuszczów. W rezultacie prowadzi to do przekształcenia tłuszczu w wolne kwasy tłuszczowe w celu dalszego łatwego ich spalenia.


Badania 1:

Forskolin &#8211; a libido i testosteron.

A)

The subject population consisted of 30 men who were overweight/obese (BMI 26 kg/m2). Of the 30 individuals recruited, 15 were randomly assigned to receive forskolin supplementation for the 12-week trial period (n = 15), whereas the other 15 subjects were assigned a placebo (n = 15).





There was a significant difference among groups at pre&#8211;, mid&#8211;, and post&#8211;time-points for total testosterone (p 0.05). A trend toward a significant increase in total testosterone existed within the forskolin group from pre- and post-time periods (p = 0.051). The percentage change for total testosterone for all time-points can be seen in Table 2. Finally, a trend toward a significant increase for the forskolin group existed in regard to the actual change in total testosterone from pre&#8211; to post&#8211;time-points (p = 0.057). The coefficient of variations was 7% for intra-assay and 3% for inter-assay.
Free Testosterone. There was a significant change across time for free testosterone in the forskolin group (p 0.05). There was no significant difference among groups for free testosterone for all time-points. When the actual change in free testosterone was examined, there was a significant increase in the forskolin group from pre&#8211; to post&#8211;time-points (p 0.05). The coefficient of variations was 9% for intra-assay and 8% for inter-assay.

The Testosterone of the forskolin group rose 33.7 percent, while it decreased 18.35 percent in the placebo group.

http://www.nature.com/oby/journal/v13/n8/full/oby2005162a.html 

B)

One such product is a feminine massage oil that contains borage seed oil, evening primrose oil, extracts of angelica and coleus, and several antioxidants. A randomized, double-blinded, cross-over study was conducted to evaluate the efficacy of this product in women who had been diagnosed with female sexual arousal disorder. The treatment resulted in increases in sexual pleasure in more than 90 percent of women

Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness


Badania 2:

Forskolin &#8211; a cAMP.

A)

Immunoassays were performed to study the effect of testosterone on intracellular cAMP level in the efferent duct epithelium. Under basal condition, the intracellular cAMP content was 45.8 &#177; 17.2 pmol/well (mean &#177; SE, n = 7). Stimulating the tissues with forskolin (10 &#181;M) led to a rise in intracellular cAMP content to 140.7 &#177; 11.7 pmol/well (mean &#177; SE, n = 4) (P < 0.01). Testosterone (10 &#181;M) did not affect the basal intracellular cAMP but significantly inhibited the forskolin-induced rise of cAMP in a concentration-dependent manner





http://ajpcell.physiology.org/cgi/content/full/280/5/C1160

B)

The diterpene forskolin markedly activates adenylate cyclase in membranes from various rat brain regions and elicits marked accumulations of radioactive cyclic AMP in adenine-labeled slices from cerebral cortex, cerebellum, hippocampus, striatum, superior colliculi, hypothalamus, thalamus, and medulla-pens. In cerebral cortical slices, forskolin has half-maximal effects at 20&#8211;30 &#956;m on cyclic AMP levels, both alone and in the presence of the phosphodiesterase inhibitor ZK 62771. The presence of a very low dose of forskolin (1 &#956;m) can augment the response of brain cyclic AMP-generating systems to norepinephrine, isoproterenol, histamine, serotonin, dopamine, adenosine, prostaglandin E2, and vasoactive intestinal peptide. Forskolin does not augment responses to combinations of histamine-norepinephrine, adenosine-norepinephrine, or histamine-adenosine. For norepinephrine and isoproterenol in rat cerebral cortical slices and for histamine in guinea pig cerebral cortical slices, the presence of 1 &#956;m-forskolin augments the apparent efficacy of the amine, whereas for adenosine, prostaglandin E2, and vasoactive intestinal peptide, the major effect of 1 &#956;m-forskolin is to increase the apparent potency of the stimulatory agent. In rat striatal slices, forskolin reveals a significant response of cyclic AMP systems to dopamine and augments the dopamine-elicited activation of adenylate cyclase in rat striatal membranes. The activation of cyclic AMP systems by forskolin is rapid and reversible, and appears to involve both direct activation of adenylate cyclase and facilitation and/or enhancement of receptor-mediated activation of the enzyme.

http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.1982.tb08660.x/abstract

C)

Forskolin, a plant cardiotonic diterpene, stimulated proteoglycan biosynthesis by chondrocytes in monolayer culture. The quantitative increase in proteoglycans was dependent on the concentration of forskolin, but was relatively independent of the presence of serum. At forskolin concentrations that stimulated proteoglycan synthesis, a significant stimulation of adenylate cyclase and cAMP was also measured. The quantitative increase in proteoglycans was characterized, qualitatively, by an increased deposition of newly synthesized proteoglycan in the cell-associated fraction. An analysis of the most dense proteoglycans (fraction dA1) in the cell-associated fraction showed that more of the proteoglycans eluted in the void volume of a Sepharose CL-2B column, indicating that an increased amount of proteoglycan aggregate was synthesized in forskolin-treated cultures. The proteoglycan monomer dA1D1 secreted into the culture medium of forskolin-stimulated cultures overlapped in hydrodynamic size with that of control cultures, although cultures stimulated with forskolin and phosphodiesterase inhibitors produced even larger proteoglycans. The hydrodynamic size of 35SO4 and 3H-glucosamine-labelled glycosaminoglycans isolated from the dA1D1 fraction of the culture medium was greater in forskolin-treated chondrocytes, especially from those in which phosphodiesterase inhibitors had been added. These results indicated that forskolin, a direct activator of chondrocyte adenylate cyclase mimicked the effects of cAMP analogues on chondrocyte proteoglycan synthesis previously reported. These results implicate activation of adenylate cyclase as a regulatory event in the biosynthesis of cartilage proteoglycans, and more specifically in the production of hydrodynamically larger glycosaminoglycans.

http://onlinelibrary.wiley.com/doi/10.1002/jcp.1041290108/abstract

D)

Coleus barbatus Benth.] (Valdes et al. 1987). It is possible that Coleus blumei may also contain forskolin or a similar substance. However, an initial investigation of Indian plants was unable to detect any forskolin (Valdes et al. 1987,479). Forskolin activates the enzyme adenylate cyclase, an intracellular neurotransmitter that can bind to various receptors. This means that forskolin is able to exert strong indirect effects upon neurotransmission (D. McKenna 1995, 103*). Whether this can result in psychoactive effects is unknown

Christian Ratsch, The Encyclopedia of Psychoactive Plants: Ethnopharmacology and Its Applications

E)

Coleus (Coleus forskohlii) This Indian variety of coleus should not be confused with the common houseplant. The medicinal coleus can reduce the release of histamine and other inflammatory chemicals by increasing levels of a substance called cyclic adenosine monophosphate (cAMP) within cells. So far, studies have focused on its use for asthma, but researchers are currently looking at new eczema drugs that also work to prevent the breakdown of cAMP. If drug companies are willing to bet research funds on cAMP's role in eczema, then herbs that affect cAMP may be worth a try for your eczema

Linda B. White, M.D., The Herbal Drugstore

F)

A diterpene (forskolin = coleonol) that is potently bioactive has been found in the related species Coleus forskohlii (Poir.) Briq. [syn. Coleus barbatus Benth.] (Valdes et al. 1987). It is possible that Coleus blumei may also contain forskolin or a similar substance. However, an initial investigation of Indian plants was unable to detect any forskolin (Valdes et al. 1987,479). Forskolin activates the enzyme adenylate cyclase, an intracellular neurotransmitter that can bind to various receptors. This means that forskolin is able to exert strong indirect effects upon neurotransmission

Christian Ratsch, The Encyclopedia of Psychoactive Plants: Ethnopharmacology and Its Applications


Badania 3:

Forskolin &#8211; a utrata wagi.

A)

The subject population consisted of 30 men who were overweight/obese (BMI 26 kg/m2). Of the 30 individuals recruited, 15 were randomly assigned to receive forskolin supplementation for the 12-week trial period (n = 15), whereas the other 15 subjects were assigned a placebo (n = 15). The average age, BMI, and body fat percent were 24.4 5.9 years, 32.5 4.1 kg/m2, and 35.2 8.3% for the forskolin group and 28.7 8.6 years, 32.6 3.8 kg/m2, and 35.0 7.3% for the placebo group, respectively (other subject demographics are presented in Table 1). To meet the eligibility requirements for this study, individuals had to be overweight/obese (BMI 26 kg/m2), be non-active sedentary individuals, taking no antihypertensive and/or antiasthmatic medication, and must not have asthma, low blood pressure, or gastric ulcers. Before participating in the study, participants were informed of all potential risks and procedures involved with the study. Subjects signed an informed consent in concordance with the requirements of the University of Kansas Human Subjects Committee Review Board.





The forskolin group had a significant decrease in body fat percent from baseline (35.17 8.03%) to final measurement (31.03 7.96%). The placebo group showed no significant difference in body fat percent from baseline to final measurement. The actual change in body fat percent from before to after the study (-4.14 4.47% vs. -0.96 1.66% for forskolin vs. placebo, respectively) was shown to be significantly different among groups (p 0.05).
Fat Mass. After the 12-week trial period, fat mass decreased significantly in the forskolin group (p 0.05) with no change occurring in the placebo group. Additionally, the actual change in fat mass from before to after showed a significant difference among groups

http://www.nature.com/oby/journal/v13/n8/full/oby2005162a.html

B)

This study examined the effect of forskolin on body composition, testosterone, metabolic rate, and blood pressure in overweight and obese men. Thirty subjects were studied in a randomized, double-blind, placebo-controlled study for 12 weeks. Forskolin was shown to elicit favorable changes in body composition by significantly decreasing body fat percentage and fat mass. There was a trend toward a significant increase for lean body mass in the forskolin group compared with the placebo group. Oral ingestion of forskolin (250 mg of 10% forskolin extract twice a day) for a 12-week period was shown to favorably alter body composition while concurrently increasing bone mass and serum free testosterone levels in overweight and obese men. The results indicate that forskolin is a possible therapeutic agent for the management and treatment of obesity.

Obesity Research. 2005 Aug;13(8):1335-43. Godard MP, Johnson BA, Richmond SR. University of Kansas, Department of Health, Sport and Exercise Sciences, Applied Physiology Laboratory, Lawrence, KS 66045, USA.

C)

Recently, a standardized extract of C. forskohlii was evaluated in a preliminary open-field clinical study on six overweight female volunteers receiving 250 mg of the extract (equivalent to 25 mg of forskolin) twice a day for eight weeks, half an hour before a meal. Each participant was asked to maintain her previous daily physical exercise and eating habits. In addition, physical activity was monitored based on a questionnaire before and during the trial.

During the eight-week trial, the mean values for body weight and fat content significantly decreased, whereas lean body mass significantly increased compared to the baseline values. No subjective or objective adverse effects were reported in the course of this study. However, a trend to lower systolic and diastolic blood pressure was noted

http://www.mdidea.com/products/proper/proper00907.html

D)

6 overweight female volunteers received the ForsLean formula twice daily for 8 weeks. During the eight-week trial, the mean values for bodyweight and fat content significantly decreased, whereas lean body mass significantly increased compared to baseline values. Again this study showed no adverse effects associated with coleus supplementation.

http://www.sncdirect.com/snc.nsf/EzineDocs/Coleus Forskohlii?OpenDocument

E)

Researchers think coleus functions by a chain of biochemical reactions that may lead to increased thyroid activity, immunity, insulin secretion, and metabolism of fats. What's more, coleus may be involved in enhancing yet another complex chain of events that support strong, healthy, blood vessels and cardiovascular tissue.

http://www.chiroweb.com/archives/21/21/20.html

F)

To find out, Kansas State University researchers Godard, Johnson, and Richmond recruited 30 obese men.

The aim of the study was to find if colforsin caused an increase in endogenous andrenergic hormone levels; an increase in resting metabolic rate; and a favorable impact on body composition.

The trial lasted 12 weeks. Fifteen men received one tablet of colforsin in the morning and one tablet 6 to 8 hours later. The other 15 men followed the same regimen, albeit with a placebo.

Body composition tests were performed by DEXA analysis and body circumference measurements.





The colforsin group lost 4.52 kilograms (9,99 pounds) of fat, plus or minus 5.74 kilograms, while the placebo group lost only 0.51 kilograms (1.1 pounds), plus or minus 1.91 kilograms.

http://www.t-nation.com/free_online_article/sports_body_training_performance_bodybuilding_supplements/dramatic_carbolin19_study


Badania 4:

Forskolin &#8211; a relax,odpręzenie,cisnienie

A)

Positive inotropic and blood pressure lowering activity of a diterpene derivative isolated from coleus forskohlii. Forskolin. Arzneim Forsch 1978; 28: 284-289 12. Kramer W, Thormann J, Kindler M. Effects of forskolin on left ventricular function in dilated cardiomyopathy

Michael T. Murray, ND, Textbook of Natural Medicine 2nd Edition Volume 1

B)

Relaxes Bronchial Muscles The herb coleus has been used for centuries by practitioners of Ayurveda, the ancient system of natural healing from India, to relax the airways. Dr. Firshein recommends getting a product standardized for 18 percent forskolin, the active ingredient in coleus. Take 50 milligrams two or three times a day for up to a year, he says. Because coleus may enhance the effects of some asthma medications, you should discuss taking it with your doctor
Bill Gottlieb, Alternative Cures: The Most Effective Natural Home Remedies for 160 Health Problems

C)

Coleus lowers blood pressure while slowing the pulse and strengthening the heartbeat, without increasing the heart's need for oxygen. Forskolin also relaxes the smooth muscles surrounding the arteries to lower blood pressure. The chemical accomplishes this by activating "slow" calcium channels, complementing the effect of prescription calcium channel blockers. CONSIDERATIONS FOR USE Coleus should be used in the form of forskolin extract, such as forskolin dry extract from TR-Metro Natural Herbal Extracts.
Phyllis A. Balch, CNC, Prescription for Herbal Healing: An Easy-to-Use A-Z Reference to Hundreds of Common Disorders and Their Herbal Remedies

D)

Glaucoma coleus is used topically in treatments to relieve glaucoma (excess pressure within the eye, which, if untreated, can result in loss of vision). &#8226; Potential use Judging by the therapeutic effects of the constituent forskolin, coleus may be of use in combination with other herbs, such as hawthorn (Crataegus oxyacantha, p. 86), in helping to reduce high blood pressure. Parts Used Roof is unearthed in autumn when the active constituents are at their most concentrdted. Dried root Leaves have valuable medicinal properties and are also used in pickling

Andrew Chevallier, The Encyclopedia of Medicinal Plants

E)

Two herbs from the ayurvedic tradition are proving to offer much in the way of tonic support of the cardiovascular system. coleus forskohlii (coleus) offers a range of therapeutic possibilities that make it uniquely relevant in the treatment of cardiovascular diseases such as hypertension, congestive heart failure, and angina. Commiphora mukul (guggul) can be effective in lowering serum lipids. Both herbs are discussed later in this chapter. Allium sativum (garlic) has a range of effects upon cardiovascular health

David Hoffman, FNIMH, AHG, Medical Herbalism: The Science Principles and Practices Of Herbal Medicine



Jak działa Forskolin:
-podnosi poziom testosteronu
-wpływa on na wzrost produkcji AC
-powoduje wzrost cAMP
-silnie redukuje tkanke tłuszczowa
-wpływa również na działanie hormonów tarczycy
-przyspiesza metabolizm
-pobudza termogeneze
-obniża ciśnienie tętnicze krwi oraz ciśnienie wewnątrzgałkowe
-zapobiega jaskrze
-poprawia funkcjie neuroprzekaźników (zwłaszcza serotoniny i dopaminy)


W jakich suplementach wystepuje:
Applied Nutriceuticals- Drive
Applied Nutriceuticals - Free Test
Biotest - Alpha Male
Biotivia - Bio Forge
BSN - Axis HT
Competitive Edge Labs - PCT Assist
Driven Sports - Lean Xtreme
Metabolic Diet - TestoBoost
Neogenix &#8211; Supremacy

Coleus Forskholii - rozni producenci


Dawkowanie:
250 mg &#8211; gdzie 10-20% forskolin


W wielu suplementach nie wystepuje &#8211; jak widac po wklejonych badaniach, głowne zadanie to wzrost produkcji enzymu zwanego cyklazą adenylową -> to powoduje podniesienie cAMP -> to stymuluje lipolize (rozklad zmagazynowanych rezerw tluszczu).
Wpływa również na działanie hormonów tarczycy -> przyspiesza metabolizm, pobudza termogeneze &#8211; tym samym powoduje szybszą utrate tkanki tluszczowej.

Ale również podnosi testosteron co zostało przedstawione i większość odnosi się do tych badan.

Dobry suplement jeśli planuje się np. rokompozycje ciala lub redukcje &#8211; ale również podczas fazy masowania się sprawdzi powodując przyrosty w większości suchej masy.


Zmieniony przez - solaros w dniu 2010-09-16 17:18:13

A co myślicie o takim zestawie daa+6 bromo
daa jako boster teścia
a 6-bromo jako inhabitor.

do tego jeszcze niepokalanka mógłbyś dorzucić, co by prolaktynę zblokować..

Co do DAA, to nie jestem do niego w 100% przekonany. Zbyt świerzy i spimpowany produkt. Podobno może jednocześnie zwiększać poziom prolaktyny, więc możesz stać się bardziej, jakby tu powiedzieć, psychicznie kobiecy

A czym zbić poziom prolaktyny oprócz b6 6 bromo niewystarczy>

wrzuce wrzuce
raczej skonczylem juz z boosterami testosteronu - mozna by bylo powrzucac wszystkie pojedyncze skladniki ale brak wystarczajacej ilosci badan a wrzucac to co na ettykietach pisze jezeli nie jest potwierdzone badaniami mija sie z celem

powoli zbieram info na temat inhibitorów aromatazy:
Reservatrol
Chrysin
Indole-3-Carbinol (I3C) / Diindolymethane (DIM)
Agnus-Castus

opisze bardziej te 4 (wczesniej lub pozniej)

Co do agnus to jest to typwoy anhibitor aromatazy - obniza poziom estrogenów,obniza poziom progesteronu i obniza poziom prolaktyny.

Ale poziom prolaktyny obniza rowniez b6 (o czym mowa byla kilka postow wczesniej) i obniza tez Mucuna pruriens.

pitbull61
co do DAA to on podnosi chyba wiekszosc z hormonow.

Jakie sa skutki uboczne nie wiadomo jeszcze - pewnie wyjdzie kiedys jesli ktos przesadzi w dawkami albo z dlugoscia cyklu.

Na razie brak wiekszych przeciwskazan (poza wzrostem poziomu hormonow takich jak PRL,progesteron,estradiol takze).

Takze dlugosc cyklu polecana to 12-24 dni
Ja zamierzam jechca 4 tygodnie i wyciagnac max ile bedzie mozna.

bedzie DAA,bedzie inny booster tescia (mix kilku zilek),bedzie IA,bedziec cos na prolaktyne i chyba na kortyzol (phosphatidylserine ->zbieram info o nim)

wkleje tylko to teraz -



Cortisol, testosterone, lactate and growth hormone response to exercise after 10 days of oral treatment with 600 mg S-PS or placebo (pre-exercise phase -30 to 0 minutes, exercise phase: 0 to 15 minutes, recovery phase 16 to 80 minutes).


Nie tylko dawka w ilosci 600mg PS obniza kortyzol - ale rowniez podnosi ppoziom tescia:



S-PS significantly decreased cortisol (35 &#177; 0%, p < 0.01) and increased testosterone (37 &#177; 5%, p = 0.02) AUC levels and testosterone to cortisol ratio (184 &#177; 5%, p = 0.02) in comparison to placebo.

PS->phosphatidylserine
S-PS->soy-derived phosphatidylserine

Zmieniony przez - solaros w dniu 2010-09-26 19:36:36