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na_pohybel

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Szacuny 0 Napisanych postów 36 Wiek 29 lat Na forum 10 lat Przeczytanych tematów 2623

No ale to t-5 to chyba nic nie ma do t-3, mysle ze podobienstwo nazw to przypadek tutaj

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TomQ-MAG Fizjoterapeuta Moderator

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Jest liderem w tym dziale Szacuny 12041 Napisanych postów 160432 Wiek 35 lat Na forum 16 lat Przeczytanych tematów 1234391

jezeli mowa o produkcie t5 to faktycznie jest to typowe ECA

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Truth09

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Szacuny 7 Napisanych postów 141 Wiek 44 lat Na forum 14 lat Przeczytanych tematów 1256

TomQ-MAG
wszystkie imitatory hormonów tarczycy to sciema, lepiej zainwestowac w sprawdzone srodki

oczywisce ze jest inaczej:

Lombardi A., de Lange P., Silvestri E., Busiello R.A., Lanni A., Goglia F., Monreno M., 3,5-diiodothyronine rapidly enhances mitochondrial fatty acid oxidation rate and thermogenesis in rat skeletal muscle: AMP-activated protein kinase involvement, Am J Pysiol Endocrinol Metab, Dec 30 (2008).

lub

Moreno M., Lombardi A., Lombardi P., Goglia F., Lanni A., Effects of 3,5-diiodo-L-thyronine on thyroid stimulating hormone and growth hormone serum levels in hypothyroid rats, Life Sci, 62(26); 2369-77 (1998).

lub

Cimmino M., Mion F., Goglia F., Minaire Y., Geloen A., Demonstration of in vivo metabolic effects of 3,5-di-iodothyronine, J Endocrinol, May; 149(2): 319-25 (1996).

lub

Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald , Greifswald, Germany .
Pietzner M1, Lehmphul I, Friedrich N, Schurmann C, Ittermann T, Dörr M, Nauck M, Laqua R, Völker U, Brabant G, Völzke H, Köhrle J, Homuth G, Wallaschofski H. 24 Oct. 2014

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Truth09

Początkujący

Szacuny 7 Napisanych postów 141 Wiek 44 lat Na forum 14 lat Przeczytanych tematów 1256

TomQ-MAG
wszystkie imitatory hormonów tarczycy to sciema, lepiej zainwestowac w sprawdzone srodki

...

TomQ-MAG Fizjoterapeuta Moderator

Ekspert

Jest liderem w tym dziale Szacuny 12041 Napisanych postów 160432 Wiek 35 lat Na forum 16 lat Przeczytanych tematów 1234391

Truth09
TomQ-MAG
wszystkie imitatory hormonów tarczycy to sciema, lepiej zainwestowac w sprawdzone srodki

oczywisce ze jest inaczej:

Lombardi A., de Lange P., Silvestri E., Busiello R.A., Lanni A., Goglia F., Monreno M., 3,5-diiodothyronine rapidly enhances mitochondrial fatty acid oxidation rate and thermogenesis in rat skeletal muscle: AMP-activated protein kinase involvement, Am J Pysiol Endocrinol Metab, Dec 30 (2008).

lub

Moreno M., Lombardi A., Lombardi P., Goglia F., Lanni A., Effects of 3,5-diiodo-L-thyronine on thyroid stimulating hormone and growth hormone serum levels in hypothyroid rats, Life Sci, 62(26); 2369-77 (1998).

lub

Cimmino M., Mion F., Goglia F., Minaire Y., Geloen A., Demonstration of in vivo metabolic effects of 3,5-di-iodothyronine, J Endocrinol, May; 149(2): 319-25 (1996).

lub

Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald , Greifswald, Germany .
Pietzner M1, Lehmphul I, Friedrich N, Schurmann C, Ittermann T, Dörr M, Nauck M, Laqua R, Völker U, Brabant G, Völzke H, Köhrle J, Homuth G, Wallaschofski H. 24 Oct. 2014

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a co do zion t5 to eca jest tylko na etykiecie.

Zmieniony przez - Truth09 w dniu 2015-01-19 12:54:34

fajne, tylko, ze badania były robione na szczurach...
wiec dowodów na działanie w ustroju człowieka nie ma.

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Truth09

Początkujący

Szacuny 7 Napisanych postów 141 Wiek 44 lat Na forum 14 lat Przeczytanych tematów 1256

najpierw zapoznaj sie z badaniami a potem komentuj, badania były na ludziach, 3,3-diiodothyronina działa tylko na szczurach, a tu mowa o 3,5 diiodothyronina. 3 z 4 podanych badań dotyczy ludzi

Zmieniony przez - Truth09 w dniu 2015-01-19 20:51:56

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na_pohybel

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Szacuny 0 Napisanych postów 36 Wiek 29 lat Na forum 10 lat Przeczytanych tematów 2623

To jaki jest najmocniejszy z tych sprawdzonych ? Jest coś lepszego od Black Bombs na rynku ?

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TomQ-MAG Fizjoterapeuta Moderator

Ekspert

Jest liderem w tym dziale Szacuny 12041 Napisanych postów 160432 Wiek 35 lat Na forum 16 lat Przeczytanych tematów 1234391

Truth09
najpierw zapoznaj sie z badaniami a potem komentuj, badania były na ludziach, 3,3-diiodothyronina działa tylko na szczurach, a tu mowa o 3,5 diiodothyronina. 3 z 4 podanych badań dotyczy ludzi
Zmieniony przez - Truth09 w dniu 2015-01-19 20:51:56

ok wiec pozwole sobie zacytować co znalazlem pod odnosnikami do badan od ciebie.
jak masz cos innego podaj link.

1.badanie odnoszace sie do szczurów:
Cimmino M., Mion F., Goglia F., Minaire Y., Geloen A., Demonstration of in vivo metabolic effects of 3,5-di-iodothyronine, J Endocrinol, May; 149(2): 319-25 (1996).
Abstract

The objective of the present study was to test in vivo the metabolic effects of 3,5-di-iodothyronine (3,5-T2) in unanesthetized and unrestrained male Sprague-Dawley rats. Amino acid and lipid metabolisms were investigated by breath tests using as tracers the 13C-carboxyl-labeled molecules of leucine, alpha-ketoisocaproic acid (KIC) and octanoic acid, in four different groups of rats: hypothyroid animals (receiving propylthiouracil (PTU) and iopanoic acid), hypothyroid animals treated with either a daily i.p. injection of 3,5-T2 (25 micrograms/100 g body weight), or tri-iodothyronine (T3) (1 microgram/100 g body weight), and control euthyroid animals receiving equivalent volumes of the vehicle solutions. Energy expenditure was measured by continuous monitoring of O2 consumption and CO2 production in these different groups. Daily energy expenditure was decreased by 30% in PTU-treated rats. The chronic treatments with 3,5-T2 and T3 restored daily energy expenditure to the control level. 13CO2 recovered in breath following the i.v. injection of octanoic acid-[1-13C] was decreased in hypothyroid animals compared with control animals (P < 0.05) and restored to control values by T3 and 3,5-T2 treatments. The 13CO2 recovered in breath after i.v. injection of leucine-[1-13C] was increased in PTU-treated compared with control animals (P < 0.05). Chronic treatment with either 3,5-T2 or T3 restored 13CO2 to control values. Excretion of 13CO2 recovered in breath following the i.v. injection of KIC-[1-13C] was increased in PTU-treated compared with control animals. Chronic treatments with either 3,5-T2 or T3 did not restore KIC decarboxylation. These results suggest that 3,5-T2 exerts metabolic effects on energy expenditure, on both lipid beta-oxidation and leucine metabolism in hypothyroid rats. We conclude that 3,5-T2 is a metabolically active iodothyronine.

2. do szczurów

Lombardi A., de Lange P., Silvestri E., Busiello R.A., Lanni A., Goglia F., Monreno M., 3,5-diiodothyronine rapidly enhances mitochondrial fatty acid oxidation rate and thermogenesis in rat skeletal muscle: AMP-activated protein kinase involvement, Am J Pysiol Endocrinol Metab, Dec 30 (2008)

T2, a naturally occurring diiodothyronine, is a product of a currently unknown enzymatic process most probably utilizing T3 as its precursor (Moreno et al., 2002). Some years ago surprising results were published showing that (among a lot of iodothyronines tested) T2, at a very low concentration (pM), induced a rapid stimulation of oxygen consumption in perfused livers isolated from hypothyroid rats. In the same study, it was shown that T3 showed a similar effect but this effect was largely abolished by the addition of an inhibitor of D1 deiodinase, while the effect of T2 was not. Moreover, T2 exerted its effect more rapidly than T3 (Horst et al., 1989). Stimulated by that report and another study showing an interaction of a diiodothyronine with mitochondria (Goglia et al., 1981) some laboratories started to investigate more deeply on possible specific biological actions of T2. Initially, energy metabolism was the major area of interest. Indeed, several reports from various laboratories showed that acute or chronic administration of T2 to rats resulted in significant changes in energy metabolism. When either T3 or T2 were acutely injected to hypothyroid rats, T2 had a more rapid effect on resting metabolic rate than T3 (Lanni et al., 1996). The experimental design used in this study was basically the same as that employed by Tata in the early 1960's (Tata et al., 1962; Tata, 1963) and the only difference was that in the study of Lanni et al. hypothyroidism was achieved by the simultaneous administration of propylthiouracil (PTU) and iopanoic acid (IOP). This treatment produces animals with severe hypothyroidism and at the same time, with a powerful inhibition of all three types of deiodinase enzymes. In such conditions the effects of T2 were evident as soon as 1 h after its injection reaching the maximal value after 24 h, while that of T3 became evident only after 24 h reaching the maximal value after 72 h (these effects of T3 were overlapping to those obtained by Tata, 1963). Moreover, while the effect of T3 was inhibited by a inhibitor of transcription such as actinomycin D (as shown also by Tata, 1963). the effect of T2 was not (Lanni et al., 1996; Moreno et al., 1997) (see Figure 1).

3.do szczurow

Moreno M., Lombardi A., Lombardi P., Goglia F., Lanni A., Effects of 3,5-diiodo-L-thyronine on thyroid stimulating hormone and growth hormone serum levels in hypothyroid rats, Life Sci, 62(26); 2369-77 (1998).

Abstract
We have investigated the biological effects of physiological doses of 3,5-diiodo-L-thyronine (3,5-T2) and 3,3'iiodo-L-thyronine (3,3'-T2) (at doses from 2.5 to 10 microg/100 g BW) on serum TSH and GH levels in rats made hypothyroid by propylthiouracil and iopanoic acid administration. In such animals deiodinase activities were inhibited and thyroid hormones serum levels strongly reduced. The effects of T2s were compared with those elicited by 3,5,3'-triiodo-L-thyronine (T3) (2.5 microg/100 g BW).The serum TSH level was much greater in hypothyroid rats than in euthyroid ones. T3 administration suppressed TSH by 88% compared to control (i.e, the level in hypothyroid rats); it thus reached a value not significantly different from that seen in the euthyroid rats. 3,5-T2 produced a similar effect, suppressing the TSH level by about 75% compared to control; it thus reached values not significantly different from those of the euthyroid and T3-treated rats. By contrast, 3,3'-T2 had no effect on TSH, whatever the dose. The serum GH level was much lower in hypothyroid rats than in euthyroid ones. T3 administration increased the GH level by about 5-fold, restoring it to the value seen in euthyroid rats. 3,5-T2-treated hypothyroid rats, at all the doses used (from 2.5 to 10 microg/100 g BW), showed increased serum GH levels: at a dose of 10 microg/100 g BW the level reached a value about 5-fold higher than that in hypothyroid rats. This value was not significantly different from those of euthyroid and T3-treated rats. 3,3'-T2 did not affect GH levels whatever the dose. Thus, 3,5-T2 (but not 3,3'-T2) seems to mimic the effects of T3 on serum TSH and GH levels in rats.

4. wstep odnoszacy sie do szczurow, druga czesc bada zaleznosc pomiedzy endogennym t3 a gospodarka glukozy, a nie podawanie t3 w formie suplementacji.
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald , Greifswald, Germany .
Pietzner M1, Lehmphul I, Friedrich N, Schurmann C, Ittermann T, Dörr M, Nauck M, Laqua R, Völker U, Brabant G, Völzke H, Köhrle J, Homuth G, Wallaschofski H. 24 Oct. 2014

Background: During the last two decades, it has become obvious that 3,5-diiodothyronine (3,5-T2), a well-known endogenous metabolite of the thyroid hormones thyroxine (T4) or triiodothyronine (T3), not only represents a simple degradation intermediate of the former but also exhibits specific metabolic activities. Administration of 3,5-T2 to hypothyroid rodents rapidly stimulated their basal metabolic rate, prevented high-fat diet-induced obesity as well as steatosis, and increased oxidation of long-chain fatty acids. Objective: The aim of the present study was to analyze associations between circulating 3,5-T2 in human serum and different epidemiological parameters, including age, sex, or smoking, as well as measures of anthropometry, glucose, and lipid metabolism. Methods: 3,5-T2 concentrations were measured by a recently developed immunoassay in sera of 761 euthyroid participants of the population-based Study of Health in Pomerania. Subsequently, analysis of variance and multivariate linear regression analysis were performed. Results: Serum 3,5-T2 concentrations exhibited a right-skewed distribution, resulting in a median serum concentration of 0.24 nM (1st quartile: 0.20 nM; 3rd quartile: 0.37 nM). Significant associations between 3,5-T2 and serum fasting glucose, thyrotropin (TSH), as well as leptin concentrations were detected (p<0.05). Interestingly, the association to leptin concentrations seemed to be mediated by TSH. Age, sex, smoking, and blood lipid profile parameters did not show significant associations with circulating 3,5-T2. Conclusion: Our findings from a healthy euthyroid population may point toward a physiological link between circulating 3,5-T2 and glucose metabolism.

Zmieniony przez - TomQ-MAG w dniu 2015-01-19 22:53:09

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