LEUCYNA - ANABOLIKIEM

jakim drugim przypadku?
wskaż fragment bo mi ucieka, ja widzę:

30 fasted, recreationally trained
males (22.5 yrs; 83.1 kg; 178.4 cm)
consumed 120 mg/kg/bw of BCAA,
60 mg/kg/bw of leucine, or a
placebo.


________________


na marginesie :

Lastly, in the
current study, neither BCAA nor
leucine supplementation did not
have a significant effect on the
phosphorylation state of the cell
signaling protein, mTOR.

...

Zmieniony przez - faftaq w dniu 2010-06-18 19:31:20

Nie nie, chodziło mi o przypadek wskazany przez Ciebie - 10g leucyny z 10g BCAA (5g leucyny + plus 5g waliny i izoleucyny). Leucyna ma znaczną przewagę nad waliną i izoleucyną - to oczywiste.

a, ok

wiec wniosek iż BCAA lepsze nizleucyna - wywaga zdecydowanie dopracyzowania. BCAA lepsze niż leucyna jesli brane jest w dwukrotnie wiekszej niż ona dawce

Inaczej mówiąc, jeśli w BCAA jest tyle samo leucyny ile osobno leucyny. Z tym doprecyzowaniem, chciałem, ale uprzedziłeś moją edycję :P A ten wniosek, który wyodrębniłeś "na marginesie", istotnie wart zauważenia.

SPOKO

Ten pan, jak widać, zna lepsze serum dla mięśni niż leucyna

polecic mu trzeba by przejrzał badania w tej kwestii:

Am J Physiol Endocrinol Metab. 2003 Dec;285(6):E1205-15. Epub 2003 Aug 26.
Alcohol impairs leucine-mediated phosphorylation of 4E-BP1, S6K1, eIF4G, and mTOR in skeletal muscle.

Lang CH, Frost RA, Deshpande N, Kumar V, Vary TC, Jefferson LS, Kimball SR.

Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA. [email protected]
Abstract

Acute alcohol (EtOH) intoxication impairs skeletal muscle protein synthesis. Although this impairment is not associated with a decrease in the total plasma amino acid concentration, EtOH may blunt the anabolic response to amino acids. To examine this hypothesis, rats were administered EtOH or saline (Sal) and 2.5 h thereafter were orally administered either leucine (Leu) or Sal. The gastrocnemius was removed 20 min later to assess protein synthesis and signaling components important in translational control of protein synthesis. Oral Leu increased muscle protein synthesis by the same magnitude in Sal- and EtOH-treated rats. However, the increase in the latter group was insufficient to overcome the suppressive effect of EtOH, and the rate of synthesis remained lower than that observed in rats from the Sal-Sal group. Leu markedly increased phosphorylation of Thr residues 36, 47, and 70 on 4E-binding protein (BP)1 in muscle from rats not receiving EtOH, and this response was associated with a redistribution of eukaryotic initiation factor (eIF) 4E from the inactive eIF4E. 4E-BP1 to the active eIF4E. eIF4G complex. In EtOH-treated rats, the Leu-induced phosphorylation of 4E-BP1 and changes in eIF4E availability were partially abrogated. EtOH also prevented the Leu-induced increase in phosphorylation of eIF4G, the serine/threonine protein kinase S6K1, and the ribosomal protein S6. Moreover, EtOH attenuated the Leu-induced phosphorylation of the mammalian target of rapamycin (mTOR). The ability of EtOH to blunt the anabolic effects of Leu could not be attributed to differences in the plasma concentrations of insulin, insulin-like growth factor I, or Leu. Finally, although EtOH increased the plasma corticosterone concentration, inhibition of glucocorticoid action by RU-486 was unable to prevent EtOH-induced defects in the ability of Leu to stimulate 4E-BP1, S6K1, and mTOR phosphorylation. Hence, ethanol produces a leucine resistance in skeletal muscle, as evidenced by the impaired phosphorylation of 4E-BP1, eIF4G, S6K1, and mTOR, that is independent of elevations in endogenous glucocorticoids.

To ostatnie też ciekawe...!

nie ma w takim razie badań w których podawano by grupom testowym taką samą ilość leucyny co bcaa?
bo tak jak już ktoś napisał, robienie badań typu 5g leucyny vs 5g leucyny + 5g waliny i izoleucyny jest bezsensowne

ostatnie badanie wskazuje jakby na to, że TYLKO leucyna oddziaływuje na mTOR?


PS. ale Ty Faftaq wielki jesteś:O
i do tego zmotoryzowany

Zmieniony przez - Dzedor w dniu 2010-06-19 12:02:15

Nie, z tego wynika, że żaden z tych dwóch supli nie wpływał znacząco na fosforylację białek ze szlaku mTOR.
No cóż - to nie hormony. Ważne, że jednak działają.