DO AMBROZIAKA jabłaczan a kreatynina

fosforan kreatyny byl (oralny) w sprzedazy w PL jakos w polowie lat 90tych chyba z MLO , wycofano go z rynku bodajże ze wzgledu na wyjatkowa niestabilnosc

Creatineethyl ester (CEE) is a commercially available synthetic creatine thatis now widely used in dietary supplements. It comprises of creatinewith an ethyl group attached and this molecular configuration isreported to provide several advantages over creatine monohydrate (CM).The Medical Research Institute (CA, USA)claim that the CEE in their product (CE2) provides greater solubilityin lipids, leading to improved absorption. Similarly San (SanCorporation, CA, USA)claim that the CEE in their product (San CM2 Alpha) avoids thebreakdown of creatine to creatinine in stomach acids. Ultimately it isclaimed that CEE products provide greater absorption and efficacy thanCM. To date, none of these claims have been evaluated by anindependent, or university laboratory and no comparative data areavailable on CEE and CM.

Thisstudy assessed the availability of creatine from three commercialcreatine products during degradation in acidic conditions similar tothose that occur in the stomach. They comprised of two productscontaining CEE (San CM2 Alpha and CE2) and commercially available CM(CreapureÒ).An independent laboratory, using testing guidelines recommended by theUnited States Pharmacopeia (USP), performed the analysis. Each productwas incubated in 900ml of pH 1 HCL at 37± 1oCand samples where drawn at 5, 30 and 120 minutes. Creatine availabilitywas assessed by immediately assaying for free creatine, CEE and thecreatine breakdown product creatinine, using HPLC (UV)

After30 minutes incubation only 73% of the initial CEE present was availablefrom CE2, while the amount of CEE available from San CM2 Alpha was evenlower at only 62%. In contrast, more than 99% of the creatine remainedavailable from the CM product. These reductions in CEE availabilitywere accompanied by substantial creatinine formation, without theappearance of free creatine. After 120minutes incubation 72% of the CEEwas available from CE2 with only 11% available from San CM2 Alpha,while more than 99% of the creatine remained available from CM.

CEEis claimed to provide several advantages over CM because of increasedsolubility and stability. In practice, the addition of the ethyl groupto creatine actually reduces acid stability and accelerates itsbreakdown to creatinine. This substantially reduces creatineavailability in its esterified form and as a consequence creatines suchas San CM2 and CE2 are inferior to CM as a source of free creatine.


Department of Life Sciences, Kingston University, Penrhyn Rd, Kingston-upon-Thames, United Kingdom. 2Universityof Northumbria, Sport Sciences, Northumbria University, NorthumberlandBuilding, Newcastle upon Tyne, United Kingdom,[email protected]

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All American Pharmaceutical and Natural Foods Corp. (Billings, MT, USA)claim that Kre-alkalyn® (KA) a “Buffered” creatine, is 100% stable instomach acid and does not convert to creatinine. In contrast, they alsoclaim that creatine monohydrate (CM) is highly pH labile with more than90% of the creatine converting to the degradation product creatinine instomach acids. To date, no independent or university laboratory hasevaluated the stability of KA in stomach acids, assessed its possibleconversion to creatinine, or made direct comparisons of acid stabilitywith CM.

Thisstudy examined whether KA supplementation reduced the rate of creatineconversion to creatinine, relative to commercially available CM(CreapureÒ).Creatine products were analyzed by an independent commercial laboratoryusing testing guidelines recommended by the United States Pharmacopeia(USP). Each product was incubated in 900ml of pH 1 HCL at 37± 1oC and samples where drawn at 5, 30 and 120 minutes and immediately analyzed by HPLC (UV) for creatine and creatinine.

Incontrast to the claims of All American Pharmaceutical and Natural FoodsCorp., the rate of creatinine formation from CM was found to be lessthan 1% of the initial dose, demonstrating that CM is extremely stableunder acidic conditions that replicate those of the stomach. This studyalso showed that KA supplementation actually resulted in 35% greaterconversion of creatine to creatinine than CM. In conclusion theconversion of creatine to creatinine is not a limitation in thedelivery of creatine from CM and KA is less stable than CM in the acidconditions of the stomach.


Universityof Northumbria, Sport Sciences, Northumbria University, NorthumberlandBuilding, Newcastle upon Tyne, United Kingdom, 2Department of Life Sciences, Kingston University, Penrhyn Rd, Kingston-upon-Thames, United Kingdom. [email protected]

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zaczerpniete z Body Factory

A fosforan faktycznie byl kiedys sprzedawany przez MLO i ...

... chwalony przez Slawka Ambroziaka ktory wtedy byl w ich Team'ie o ile pamietam

no coz ... kazdy ma prawo sie pomylic

Chwaliłen CF - owszem - ale to było prawie 15 lat temu, kiedy nie byliśmy jeszcze mądrzejsi o późniejsze badania. Dzisiaj wiadomo, że fosfokreatyna nie przenika - jako taka - do organizmu z przewodu pokarmowego.
Spice - te badania są ciekawe i dobrze mi znane. Nigdy nie byłem fanem jednej z tych form kreatyny. Jednak, w przypadku estru, przydałyby się badania porównujące skuteczność supelentacji CEE z CM, jakie wykonał Albion na chelacie kreatynowym magnezu, gdyż - jak wskazuje teoria farmakokinetyki - estry najczęściej wchłaniają się lepiej, aniżeli wolna substancja.