Mial byc typowy BOOSTER TESTOSTERONU - ale jak wiadomo w wiekszosci przypadków kazda 'roslinka' przewaznie ma wielorakie dzialanie,wiec nie tylko buzer tescia ale takze inne prozdrowtone wlasciwoscia:
Horny Goat Weed -> ICARIIN
W języku chińskim Horny Goat Weed nosi nazwę "Yin Yang Huo". Nazwa naukowa to Herba Epidemii. Jest to kwitnąca roślina rosnąca w dużych ilościach w Chinach, jak i pewnych obszarach Azji.
Ten gatunek należy do rodziny berberysowatych (Berberidaceae). Horny goat weed to mrozoodporna roślina wieloletnia. Kwiaty mają po cztery płatki.
W tradycji chińskiej jest legenda o pasterzu kóz, który odkrył, że to ziele stymulowało pociąg seksualny u jego kóz, po tym jak je zjadły. Dlatego też to zioło znane jest powszechnie w Chinach jako "horny goat weed" (ziele podnieconej kozy).
Ogólnie uważa się, że jest wspaniałą alternatywą viagry dla mężczyzn z problemami z potencją. Naukowcy zbadali to zioło i potwierdzili, że Epidemii wykazuje właściwości afrodyzjaka. Odkryli aktywny składnik: Icariin. Icariin może podnieść poziom tlenku azotu, który z kolei odpręża mięśnie gładkie. Naukowcy odkryli, że icariin rozluźnia tkankę prącia u królika. Poza tym badania wykazały, że u szczurów (po wstrzyknięciu ekstraktu Epidemium bezpośrednio w penisa) wzrosło ciśnienie krwi w penisie. Naukowcy wskazują, iż icariin może blokować PDE5, czyli enzym zmniejszający przepływ krwi do penisa, a zatem uniemożliwiający erekcję. Stąd wniosek, że głównie icariin odpowiada za właściwości afrodyzjakalne Epidemium.
Rzeczywiście, zioło to jest zazwyczaj przepisywane przez specjalistów tradycyjnej medycyny chińskiej jak lek na impotencję, wraz z innymi ziołami. Jest powszechnie dostępny na rynku azjatyckim i spożywany jako suplement diety
IKARYNA - Istotnie zarówno doświadczenia empiryczne, jak i badania naukowe wskazują na możliwości zwiększenie libido za sprawą ikaryn. Zwiększa ona ukrwienie i unaczynienie naczyń kapilarnych w mięśniach i narządach płciowych. Daje to możliwość stosowania jej zarówno dla polepszenia funkcji seksualnej, jak i polepszenia jakości treningu. Okazało sie bowiem, że pełni ona rolę mediatora w powstawaniu tlenku azotu.
Niezwykle ciekawy okazuje się mechanizm działania ikaryn na uklad hormonalny. Dowiedziono, że zdolne są do kontroli poziomu testosteronu i kortyzolu. Właściwie powodują wzrost poziomu naszego endogennego testosteronu przy jednoczesnej redukcji katabolicznego hormonu kortyzolu, określanego często jako hormon stresu.
Kortyzol powoduje tez bezpośrednie obniżenie sprawności seksualnej i odbieranie ochoty do współżycia. Dlatego własnie modulacja poziomu tych dwóch hormonów w organizmie mężczyzny jest taka ważna. Badania wykazały, że substancje aktywne tej rośliny działają adaptogennie. Wpływają także na prawidłowy poziom adrenaliny, noradrenaliny, serotoniny i dopaminy. Umożliwia to nie tylko kontrolę prawidłowego stanu metabolizmu, ale działa także antydepresyjnie, tonizująco.
Ważnym aspektem wydaje sie też podniesienie poziomu hormonów tarczycowych przy jednoczesnym wzroście poziomu testosteronu, co wpływa niewątpliwie na budowanie beztłuszczowej masy mięsniowej. Równie ważne jest działanie immunomodulujące polegające na wzroście ogólnej odporności organizmu przed infekcjami. Naukowo potwierdzono także, że związki czynne Epimedium poprawiają stan tkanki kostnej i doskonale chronią watrobę przed wszelkimi uszkodzeniami.
Icariin a - TESTOSTERON
To evaluate the testosterone mimetic properties of icariin.
METHODS: Forty-eight healthy male Sprague-Dawley rats at the age of 15 months were randomly divided into four groups with 12 rats each: the control group (C), the model group (M), the icariin group (ICA) and the testosterone group (T). The reproductive system was damaged by cyclophosphamide (intraperitoneal injection, 20 mg/kg x day) for 5 consecutive days for groups M, ICA and T, at the sixth day, ICA (gastric gavage, 200 mg/kg x day) for the ICA group and sterandryl (subcutaneous injection, 5 mg/rat . day) for the T group for 7 consecutive days, respectively. The levels of serum testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH), serum bone Gla-protein (BGP) and tartrate-resistant acid phosphatase activity in serum (StrACP) were determined. The histological changes of the testis and the penis were observed by microscope with hematoxylin-eosin (HE) staining and terminal deoxynucleotidyl transferase biotin-dUTP-X nick end labeling (TUNEL), respectively. RESULTS: (1) Icariin improved the condition of reproductive organs and increased the circulating levels of testosterone. (2) Icariin treatment also improved the steady-state serum BGP and might have promoted bone formation. At the same time, it decreased the serum levels of StrACP and might have reduced the bone resorption. (3) Icarrin suppressed the extent of apoptosis of penile cavernosal smooth muscle cells. CONCLUSION: Icariin has testosterone mimetic properties and has therapeutic potential in the management of hypoandrogenism.
This study utilized 4 groups-
1) Control (eugonadal)
2) Model (induced testicular injury)
3) Icariin (induced testicular injury + Icariin)
4) Testosterone (induced testicular injury + Testosterone)
After 7 days, blood was withdrawn and analyzed:
For the Icariin group, the total testosterone went up about 3.6x normal with a slight decrease in both FSH and LH. The weights of the testis, epididymis, and seminal vesicles were not statistically significant compared to control.
The Testosterone group, on the other hand, elevated testosterone 11.7x normal, with statistically significant increases in both LH and FSH. The weights of the testis, epididymis, and seminal vesicles were all elevated compared to control.
It is important to note that the Icariin group had lower epididymal weight, lower FSH, and lower LH then control and the M group.
Zhang ZB, Yang QT.
Department of Urology, Second Affiliated Hospital, Shantou University Medical College, Shantou 515041
Aim: To investigate the influence of an extract obtained from five Chinese medicinal plants on sexual behavior of adult male rats. Methods: The extract was administered at doses of 30, 60 and 120 mg/kg by oral gavage, acutely (one time, 45 min before mating test) or subchronically (daily for 10 days) in sexually potent and sexually sluggish/impotent rats. Sexual behavior, serum levels of luteinizing hormone (LH) and testosterone (T) were evaluated in treated rats and compared with controls receiving vehicle. The effect of the extract on central dopaminergic neurotransmission was assessed in the nucleus accumbens using a microdialysis technique. Results: In sexually potent rats, both acute and subchronic treatment with the extract dosed at 30 and 60 mg/kg reduced mount latency and intromission latency. In sluggish/impotent rats, the acutely administered extract at the dose of 60 mg/kg shortened ejaculation latency, whereas subchronically administered at the doses of 30 and 60 mg/kg, reduced mount, intromission and ejaculation latencies, increasing also the percentage of mounting and ejaculating rats. The extract dosed at 60 mg/kg significantly increased LH and T following acute and subchronic administration and increased 3,4-dihydroxyphenylacetic acid levels in the nucleus accumbens, 30 min after the acute administration.
Conclusion: The improvement in both appetitive and consummatory components of sexual behavior observed in male rats treated with the extract could be ascribed to increased serum T level in parallel with the activation of the central dopaminergic system.
It had been found that Yang-restoring herb medicines Radix Aconiti Praeparata (AP), Cortex Cinamomi(CC), Herba Cistanchis(HC) and Epimedium brevicorum (EB) reduced the cold-resistant potential of normal mice and disturbed the balance of thyroid hormones in normal rats. The aim of this study was to further investigate the effects of these four herb medicines on the levels of plasma corticosterone (B), testosterone (T) and triiodothyronine (T3) in rats by administering herbs together (mixed group) or individually. It was shown that all four Yang-restoring herbs tended to raise plasma B level and it was significant in HC, EB and mixed groups, especially in HC administered rats (P less than 0.001). Rise of plasma T level was seen in CC and mixed groups. All four herbs could decrease plasma T3 level and it was significant in AP, CC and mixed groups, particularly evident in AP administered rats (P less than 0.001). This may be one of the adaptating-protecting mechanisms of normal organism against the toxicity of AP. Combination of the four herb medicines did not result in the cumulation of effects of the given medicines, however, this did reflect the average effect of these four herbs, which showed a restraining and harmonious relationship in a Chinese medical prescription.
In this report, the traditional idea that sheep fat processed Herba Epimedii warms the kidney and thus invigorate "Yang" has been tested and verified by modern pharmacological methods. Experimental findings indicate that raw Herba Epimedii does not help improve the sexual function, while well processed Herba Epimedii produces apparent effects on the improvement of sexuality.
The present study evaluated the effects of icariin (the main component of Epimedium herbs) and an extract of Cuscuta seeds on the development of the sex organs of immature male mice in vivo and on the functions of rat Leydig cells in vitro. Icariin increased the wts. of the immature mouse epididymis and seminal vesicles. Cuscuta seed extract had the same effect on the testis and epididymis, but was not as potent as human chorionic gonadotropin. In the culture medium of adult rat Leydig cells, icariin increased basal testosterone secretion and cAMP production Cuscuta seed extract enhanced basal and gonadotropin-stimulated testosterone secretion. The results suggest that icariin possesses an androgen-like effect and may increase testosterone secretion via an action on cAMP. Cuscuta seed extract acts mainly like gonadotropic hormone.
Icariin a - Zaburzenia erekcji & libido
To investigate the effect of icariin on erectile function and the expression of nitric oxide synthase (NOS) isoforms in castrated rats. METHODS: Thirty-two adult male Wistar rats were randomly divided into one sham-operated group (A) and three castrated groups (B, C and D). One week after surgery, rats were treated with normal saline (groups A and B) or oral icariin (1 mg/[kg.day] for group C and 5 mg/[kg.day] for group D) for 4 weeks. One week after treatment, the erectile function of the rats was assessed by measuring intracavernosal pressure (ICP) during electrostimulation of the cavernosal nerve. The serum testosterone (ST) levels, the percent of smooth muscle (PSM) in trabecular tissue, and the expression of mRNA and proteins of neuronal nitric oxide synthase (nNOS), inducible nitric oxide synthase (iNOS), endothelial nitric oxide synthase (eNOS) and phosphodiesterase V (PDE5) in corpus cavernosum (CC) were also evaluated. RESULTS: ICP, PSM, ST and the expression of nNOS, iNOS, eNOS and PDE5 were significantly decreased in group B compared with those in group A (P 0.01). However, ICP, PSM and the expression of nNOS and iNOS were increased in groups C and D compared with those in group B (P 0.05). Changes in ST and the expression of eNOS and PDE5 were not significant (P 0.05) in groups C and D compared with those in group B.
CONCLUSION: Oral treatment with icariin ( 98.6 % purity) for 4 weeks potentially improves erectile function. This effect is correlated with an increase in PSM and the expression of certain NOS in the CC of castrated rats. These results suggest that icariin may have a therapeutic effect on erectile dysfunction.
Asian J Androl. 2005 Dec;7(4):381-8.
Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats.
Liu WJ, Xin ZC, Xin H, Yuan YM, Tian L, Guo YL
We tested the effect of icariin on erectile function of the penis. Icariin, sidenafil and papaverine increased the intracavernous pressure in a dose-depended manner. Icariin increases intracavernous pressure.
Zhonghua Yi Xue Za Zhi. 2004 January.
In the present study, we investigated the inhibitory effect of icariin on PDE5 and PDE4 with papaverine as the control drug. Icariin and papaverine had a dose-dependent inhibitory effect on PDE4 and PDE5. Our previous studies showed that icariin significantly increased the cGMP levels of penile and clitoral CC in rabbits [20, 21]. In conclusion, icariin has a selective inhibitory effect on cGMP-specific PDE5 compared to cAMP-specific PDE4 and may be developed into an oral effective agent useful for the treatment of ED.
Herba of Epimedium koreanum is used in
traditional Chinese and Korean herbal medicine as a potent enhancer of erectile function. Icariin, the main active component of Epimedium koreanum,possesses many biological effects, such as improving cardiovascular
function, hormone regulation, immunological function modulation, and anti-tumor activity. AIM OF THE STUDY: This study supports the traditional use of extracts from Epimedium species in erectile dysfunction. MATERIALS
AND METHODS: The Epimedium koreanum dry extract was suspended in wheat germ oil using lecithin and bee wax for oral administration. The effect of oral
administration of two compositions (E-01 and E-02) standardized by their icariin content on the number of complete intromissions, the number of
ejaculations, and the latent period of ejaculation (LPE) in rats were evaluated. E-01 and E-02 were administered orally for 10 days to the experimental animals. The control animals received olive oil for 10 days. On
day 10, 0.5h after the dose was administered to male rats, one virgin female rat was placed with one male rat. RESULTS: The number of complete intromissions increased to 23.3+/-2.6 in the E-01 and E-02 group (dose 300
mg/kg body weight) (b.wt) and to 20.1+/-2.3 in the E-02 group (dose 750 mg/kg b.wt) compared with 15.2+/-2.4 in the control group of aged rats. The number of ejaculations increased from 1.1+/-0.3 in the control-aged group to
2.6+/-0.4 in the E-01 group. The LPE of male rats was 14.2+/-1.8 min in the control-aged group. The LPE of the aged group was reduced to 9.8+/-1.5 min,
9.8+/-1.6 min, and 11.4+/-1.8 min when treated with E-01 at a dose of 300mg/kg b.wt, and E-02 at a dose of 300 mg/kg b.wt and 750 mg/kg b.wt,
respectively. CONCLUSION: It was established that oral administration of lipid-based suspension of dry extract of Epimedium koreanum in wheat germ
oil improved erectile function of aged rats.
Interregional Center Adaptogen, 47/5 Piskarevsky pr., 195067 St.-Petersburg,
In this study, 25 healthy men (HM) and 13 men (VM) who used Viagra were assigned to initially receive daily therapy for 45 days with two capsules (808 mg x 2) of a commercially-prepared herbal complex of epimedium grandiflorum, maca pure (lepidium meyenii), mucuna pruriens, and polypodium vulgare . An additional four capsules (3232 mg) were taken one to two hours prior to sexual activity to determine its effect on sexual interest, sexual performance, and overall sexual satisfaction. After 45 days, the double-blind phase of the study began with a placebo product and active product randomly given to healthy men (HM) who had reported a positive response and taken for two weeks to four weeks. All subjects were evaluated after the first 45 days of treatment and finally after 60 days.
Results: 13 of 20 HM had a positive response to the herbal mixture and 6 of the 13 VM had a positive response to the herbal mixture. In the double-blind placebo portion of the study, no HM had a positive response to placebo product; 6 of the 7 HM had a positive response to the active product.
Conclusions: Daily use of the herbal complex for a minimum of 45 days resulted in an enhancement of sexual satisfaction in 60 percent of healthy male subjects and 45 percent of men using Viagra. The exact mechanism of action of the herbal mixture is unknown although it may have a testosterone-like effect.
In a study done by Steven Lamm, M.D, 38 men were administered 2 capsules (2 X 800mg) of herbal complex of epimedium grandiflorum, maca pure (lepidium meyenii), mucuna pruriens,and polypodium vulgare (in short, Horny Goat Weed) for 45 days:25 were healthy men and 13 were men already taking Vi agra. Another 4 capsules of Horny Goat Weed were taken 1 to 2 hours prior to sexual activities.
The study found 13 of 20 healthy men responded positively to Horny Goat Weed, and 6 of the 13 men already on Viagra also had a positive effect from using Horny Goat Weed. In most cases, the men reported overall improvement in sexual satisfaction and increase in sexual desires.
To clarify the mechanism of the therapeutic action of icariin on erectile dysfunction (ED). METHODS: PDE5 was isolated from the human platelet and PDE4 from the rat liver tissue using the FPLC system (Pharmacia, Milton Keynes, UK) and the Mono Q column. The inhibitory effects of icariin on PDE5 and PDE4 activities were investigated by the two-step radioisotope procedure with [(3)H]-cGMP/[(3)H]-cAMP. Papaverine served as the control drug. RESULTS: Icariin and papaverine showed dose-dependent inhibitory effects on PDE5 and PDE4 activities. The IC(50) of Icariin and papaverine on PDE5 were 0.432 micromol/L and 0.680 micromol/L, respectively and those on PDE4, 73.50 micromol/L and 3.07 micromol/L, respectively. The potencies of selectivity of icariin and papaverine on PDE5 (PDE4/PDE5 of IC(50)) were 167.67 times and 4.54 times, respectively. CONCLUSION: Icariin is a cGMP-specific PDE5 inhibitor that may be developed into an oral effective agent for the treatment of ED.
Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities.Xin ZC, Kim EK, Lin CS, Liu WJ, Tian L, Yuan YM, Fu J.
Department of Urology, the 1st Hospital, Peking University, 8 Xishiku Street, Xicheng District, Beijing 100034, China
Icariin a - Antyoksydant , ochrona wątroby & działanie antyrakowe
The aim of the present work was to explore the anti-hepatoma effects of icariin both in vitro and in vivo and to elucidate its potential mechanism of action. Icariin showed anticancer efficacy both in vitro and in vivo. The possible mechanism of action could be related to its anti-angiogenesis and anti-proliferative effects in tumors.
Am J Chin Med. 2009; Integrated Laboratory of TCM and Western Medicine of Peking University First Hospital and Integrated Institute of TCM and Western Medicine of Peking University, Beijing 100034, China.
Icariin is a biological response modifier and differentiational agent. In order to further elucidate the reversion of malignant phenotypes of tumor cells and the mechanism of its action, highly metastatic human lung cancer cells (PG) were treated with Icariin in vitro. The results showed that icariin could influence the distribution of PG cells cycle and reduce S phase. Moreover, Icariin increased the level of cAMP in PG cells, reduced the level of cGMP and increased the cAMP/cGMP ratio. These data demonstrate that Icariin maybe a type of effective anticancer drug.
Zhong Yao Cai. 2000 Sep;23(9):554-6.
Icariin is a major constituent of flavonoids derived from the Chinese medicinal herb Epimedium revicornum Maxim. The aim of the present study was to investigate whether icariin has protective effects on learning ability and memory in a rat model of chronic cerebral hypoperfusion. 2. Chronic cerebral hypoperfusion was induced by permanent ligation of the common carotid artery in Wistar rats for 4 months. One month after permanent artery occlusion, rats were adminitered icariin at doses of 0, 30, 60 or 120 mg/kg per day, p.o., for 3 months. Neurobehavioural and neurobiochemical parameters were examined to evaluate the effects of icariin on cognitive deficits induced by chronic cerebral hypoperfusion. 3. The Morris water maze test revealed that learning ability and memory were severely impaired in untreated rats, but were significantly improved in icariin-treated rats. Icariin treatment also ameliorated chronic cerebral hypoperfusion-induced oxidative stress in the brain, as evidenced by reduced malondialdehyde formation and maintained superoxide dismutase activity. In addition, the decreased hippocampal levels of acetylcholine, acetylcholinesterase and choline acetyltransferase associated with chronic cerebral hypoperfusion were significantly prevented by icariin treatment. 4. In conclusion, icariin protects against cognitive deficits induced by chronic cerebral hypoperfusion in rats. These effects appear to be mediated through its anti-oxidant effects, as well as its effects on the circulatory and cholinergic systems.
The present study examined the protective effects of icariin against the learning and memory deficits in aluminium-treated rats and its potential mechanisms of action.
Qualified rats were treated with 1600 p.p.m. AlCl3 in drinking water for 8 months and the ability of spatial learning and memory was tested by the Morris water maze. In the place navigation test, aluminium administration significantly increased the mean escape latency and searching distance. In space probing test, aluminium markedly decreased the searching time and searching distance in the quadrant where the platform was originally located. All tests indicated deficits in rat spatial learning and memory induced by aluminium. Icariin treatment (60 and 120 mg/kg, by gavage for 3 months) dose-dependently protected against the development of aluminium-induced spatial learning and memory deficits.
To examine the mechanisms responsible for the protection afforded by icariin, the superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in the hippocampus were assayed biochemically and the level of Aβ1−40 in the hippocampus was determined immunohistochemically. Icariin treatment significantly increased SOD activity and decreased MDA and Aβ1−40 content in the hippocampus of aluminium-intoxicated rats.
In conclusion, the present study demonstrates that icariin is effective in improving the spatial learning and memory of aluminium-intoxicated rats. The mechanisms responsible appear to be due, at least in part, to an increased anti-oxidant capacity and decreased lipid peroxidation and Aβ1−40 levels in the rat hippocampus.
Icariin (2-(4′-methoxylphenyl)-3-rhamnosido-5-hydroxyl-7-glucosido-8-(3′-methyl-2-butylenyl)-4-chromanone) is a flavonoid with a rhamnose as ligand. It is the major component in Herba epimedii, widely used for the treatment of atherosclerosis and neuropathy in Chinese traditional medicine, and its antioxidative property has attracted much scientific interest. The major objective of this work is to determine the antioxidative effect of icariin against oxidative DNA damage induced by 2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH). The oxidative damage of DNA was followed by measuring the formation of carbonyl compounds that can react with thiobarbituric acid (TBA) to form thiobarbituric acid reactive substance (TBARS). We found that icariin protects DNA against AAPH-induced oxidative damage in a concentration-dependent manner, although it does not affect the rate of AAPH-induced DNA damage. This result indicates that icariin is a concentration-dependent chemopreventor in protecting DNA against radical-induced damage.
Icariin (2-(4′-methoxyl phenyl)-3-rhamnosido-5-hydroxyl-7-glucosido-8-(3′-methyl-2-butylenyl)-4-chromanone) is the major component in Herba Epimedii used in traditional Chinese medicine for the treatment of atherosclerosis. This work focuses on the antioxidative effect of icariin on free-radical-induced haemolysis of human erythrocytes, in which the initial free radical derives from the decomposition of 2,2′-azobis(2-amidinopropane hydrochloride) (AAPH) at physiological temperature. To reveal the structure-activity relationship of icariin, the antioxidant effects of two structural analogues of icariin, acacetin (2-(4′-methoxylphenyl)-5,7-dihydroxylchromone) and norwogonin (2-phenyl-5,7,8-trihydroxylchromone), on the same experimental system were examined as well. It was found that all these chromone derivatives (Chm-OHs) dose-dependently protected human erythrocytes against free-radical-induced haemolysis. The order of antioxidative activity was norwogonin>acacetin>icariin by the analysis of the relationship between the concentration of Chm-OHs and the prolongation percentage of the lag time of haemolysis (PP%). It was also proved that the phenyl hydroxyl group attached to the chromone ring at 7-position cannot trap the free radical. On the contrary, phenyl hydroxyl groups at the 5- and 8-position in norwogonin made it a significant antioxidant in AAPH-induced haemolysis. The more hydroxyl groups attached to the chromone ring, the higher the antioxidative activity in protecting erythrocytes against free-radical-induced peroxidation.
In an attempt to identify compounds with antihepatotoxic activity, carbon tetrachloride-induced cytotoxicity in primary cultured rat hepatocytes has been adopted as a screening system. Using this screening system, an antihepatotoxic compound from the aerial parts of Epimedium koreanum has been isolated. This compound, icariin, is a flavonol glycoside. Its antihepatotoxic activity was first evaluated by measuring the release of glutamic pyruvic transaminase and sorbitol dehydrogenase from CCl4-intoxicated rat hepatocytes into the culture medium. Icariin significantly reduced the level of glutamic pyruvic transaminase and sorbitol dehydrogenase released resulting in a 76% protection from toxicity at concentration ranges from 1 microM to 20 microM. The antihepatotoxic activity of icariin was also estimated by the determination of total cytochrome P-450 content and glutathione-S-transferase activity in the CCl4-intoxicated hepatocytes.
Icaritin is a potent inhibitor of angiogenesis.
Endothelial cell tube formation in Matrigel is one measure of angiogenesis in vitro. The role of Icaritin in angiogenesis was assessed by determining the inhibition of HMVEC tube formation on Matrigel matrix plated onto 96-well plates. The HMVEC tube formation assay was performed as described previously. Briefly, 96-well plates were coated with 90 μL Matrigel (10 mg/mL, Collaborative Research) and incubated at 37° C. for 30 minutes to promote gelling. HMVECs (10,000 cells/sample) were resuspended in reduced growth medium (serum concentration 1% and 5 units/mL heparin) and added to each well with the indicated reagents in a final volume of 100 μL with different concentration of Icaritin. After 18 hours, the plates were fixed with Diff-Quik and at least four randomly selected fields per experimental condition were digitally recorded under bright-field illumination using a 10× objective. The mean additive length of all of the cords present in each optical field was measured using IPLab software and compared with controls using the Student's unpaired t test. The results showed that Icaritin completely inhibited the HMVEC tube formation at 10 uM. The EC50 of Icaritin to inhibit HMVEC tube formation was 5.8 uM.
We can make a conclusion that Icaritin is a potent inhibitor of angiogenesis that inhibits endothelial cell migration and tube formation.
Angiogeneza jest procesem regulowanym przez szereg czynników, aktywujących lub hamujących podziały komórek endotelialnych (ang. vascular endothelial cells). Zwykle poziom inhibitorów angiogenezy jest większy, hamując podziały komórek i wzrost naczyń.
Niestety angiogeneza jest także procesem, który umożliwia wzrost i rozwój nowotworów.
Ponieważ komórki nowotworowe, tak samo jak normalnie komórki, potrzebują do prawidłowego funkcjonowania tlenu oraz składników odżywczych, tworzenie naczyń krwionośnych wokół guza jest procesem warunkującym jego dalszy wzrost.
Czynnikiem ograniczającym jego rozwój oraz zdolność do metastazy jest angiogeneza.
Blokując proces angiogenezy można by było powstrzymać komórki nowotworowe przed dalszym wzrostem i metastazją (przeciwstawić się przerzutom).
Icariin a - ESTROGEN
W przypadku wielu produktów ICARIIN (ze wzgledu na swoje metabolity - glownie Icaritin i Desmethylicaritin) jest reklamowny jako typowy antyestrogen - lecz znalazlem takie badania:
Hormone replacement therapy (HRT) can ameliorate lipid metabolism after menopause, but it is not suitable for long-term use because of serious side effects. Herba Epimedii is a widely used herbal medicine in many Asian countries, it potentially treats menopausal syndrome and its complications with few side effects and good curative effects. The study aimed to evaluate the effects of Herba Epimedii water extract on blood lipid and sex hormone levels. Ninety subjects were randomly divided into two groups: a trial group which received Herba Epimedii water extract and a control group which was administered an equal amount of water placebo. At the baseline and after 6 months of medication, serum estradiol (E2), progesterone (P), testosterone (T), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) concentrations were measured. The results indicated that Herba Epimedii water extract decreased the TC and TG levels (p < 0.01). Furthermore, Herba Epimedii water extract significantly increased the serum level of E2 (p < 0.01) compared with the pre-treatment level. In conclusion, Herba Epimedii water extract produces its beneficial actions in postmenopausal women. Copyright © 2008 John Wiley & Sons, Ltd.
Spadl poziom trójglicerydow
podniosl sie poziom ESTRADIOLU!
Śmiało można napisac ze ‘ICARIIN’ miedzy innymi jest::
-inhibitorem 5-fosfodiesterazy (PDE-5) - pomaga w leczeniu zaburzeń erekcji
-stymulatorem libido – afrodyzjakiem
-podnosi poziom testosteronu
Ponadto ma szereg wlasciwosci prozdrowotnych:
-jest silnym antyoksydantem
-chroni wątrobę przed uszkodzeniami
-jest inhibotorem angiogenezy
-działa adaptogennie – pomaga zwalczac stres
-...i mediatorem w powstawaniu tlenku azotu - wiec tez czesto dodawany jako kolejny booster NO (wieksza pompa na treningu)
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EST - TEST DRIVE
iSatori - ISA-TEST GF
Horny Goat Weed - rozni producenci
średnie dawki w w.w. suplementach wynosza
ok.500mg Epimedium -> gdzie 40% Icariin
Zmieniony przez - solaros w dniu 2010-09-13 03:10:43