Inozyna

Na liście bestsellerów sklepiku SFD znajduje się Inozyna Nutrendu. Jednocześnie trudno w archiwum Forum cokolwiek na jej temat znaleźć. I stąd prośba o ew. komentarze osób, które miały okazję ten specyfik używać. Szczególnie w kontekście lepszego radzenia sonie z kwasem mlekowym.

ox..to jablczan cytruliny /glowny skladnik/
jesli chodzi o atp...i tepo odbudowy fosfokreatyny po wysilku /dawka 6g/d..przez 15 dni/

1'(...)CM ingestion resulted in a significant reduction in the sensation of fatigue, a 34% increase in the rate of oxidative ATP production during exercise, and a 20% increase in the rate of phosphocreatine recovery after exercise, indicating a larger contribution of oxidative ATP synthesis to energy production'

obniza tez poziom zmeczenia..m.in przez zwiekszenie wydalania amoniaku z org..i obnizenie poziomu kwasu mlekowego...
2'(...)Results showed that citrulline malate stimulates hepatic ureogenesis and favorizes the renal reabsorption of bicarbonates. These metabolic actions had a protective effect against acidosis and ammonia poisoning and explain the anti-fatigue properties of citrulline malate in man.'

wiec faktcznie wytrzymalosc moze sie zwiekszyc...tylko cena troche nie ta ;)

referencje:
1 'Citrulline/malate promotes aerobic energy production in human exercising muscle.
Bendahan D, Mattei JP, Ghattas B, Confort-Gouny S, Le Guern ME, Cozzone PJ.
Centre de Resonance Magnetique Biologique et Medicale, UMR CNRS 6612, Faculte de Medecine de la Timone, 27 Boulevard Jean Moulin, 13005 Marseille, France.'
2 'Activity of citrulline malate on acid-base balance and blood ammonia and amino acid levels. Study in the animal and in man.
Callis A, Magnan de Bornier B, Serrano JJ, Bellet H, Saumade R.
Department of Medical Biophysics, Institut de Biologie, Montpellier, France'


Zmieniony przez - v3gas w dniu 2004-03-27 15:56:56

fakt faktem, ze inozyna teoretycznie posiada kilka ciekawych wlasciwosci, jednakze tak sie sklada, iz brak przekonoojacych dowodoow zwiazanych z dzialaniem sooplementu; jako takie dzialnie odnotowano w przypadku sprinteroow, ktoorzy poddawani byli treningowi o wysokiej intensywnosci

generalnie jest to sooplement bezpieczny /dawki rzedu 5-6 g przez kilka tygodni/; u osoob podatnych inozyna moze prowadzic do naboodowania ilosci kw. moczowego

Grasik a jaki cel ma suplementacja inozyna? czy nie nei ma ona czasem tylko dzialanie pobudzającego, zwiększającego ochote do treningow? poprawe samopoczucia?

redookcja nagromadzenia kw.mlekowego, polepszenie wytrzymalosci, wzrost dostarczania o2 oraz prodookcji atp

a celu prawde moowiac nie widze zadnego - inozyna nie jest niezbedna sprawa, aby dodatkowo sie nia sooplementowac; imho jej obecnosc w sooplach wystarczy

Zmieniony przez - Grasik w dniu 2004-03-16 17:52:02

Typowy suplement na lepszy, bardziej wydajny trening.
Zwiększa liczbę ATP a to prowadzi do lepszej wydolności.
Dużo wyczynowców, kulturystów i trójboistów, stosuje ją cały czas.

stosowalem inozyne kilka lat temu...w moim przypadku sprawdzala sie dosc dobrze => robilem intensywniejsze treningi...

choc prawde mowiac jest to dosc "zapomniany" suplement...

Grasiczko, napisałaś: "redookcja nagromadzenia kw.mlekowego, polepszenie wytrzymalosci, wzrost dostarczania o2 oraz prodookcji atp, a celu prawde moowiac nie widze zadnego". Przecież te rezultaty są bardzo istotne w wielu sportach, w których cechami krytycznymi są wytrzymałość i wytrzymałość siłowa.

Podeślij mi proszę jakiegoś linka, który by wyjaśniał mechanizm działania (może być po angielsku).

wyszedl mi skroot myslowy - przepraszam
pierwsza czesc wypowiedzi dotyczyla teorii dzialania inozyny; drooga natomiast /zwrooc uwage, ze celowo nie byla po przecinku/ stanowila moje zdanie - imho nie oplaca sie sooplementowac czegos, co daje przecietne efekty /nie moowie, ze nie mozna, ale po co?/, a dwa, czegos co nie jest niezbedne /w ujeciu 'niedoboru'/
mam nadzieje, ze bardziej nie namieszalam i teraz wyglada to jasniej


co do dzialania - krootki txt, jaki udalo mi sie na teraz znalezc

7. Inosine
7.1 Background
Chemically the substance is inosine-mono-phosphate and it is a precursor for guanine- and adenosine nucleotides. Inosine itself consist of the purine hypoxanthine and the sugar ribose. Physical exercise in itself, increases the levels of inosine in the muscle (2) and the question is if a supplementation would have an additional effect.


7.2 Claims and purpose of use
Inosine has been sold to athletes since the early eighties with claims of better endurance and enhanced skeletal muscle anabolism. The statement that inosine could increase endurance originates, at least partly, from its biological importance as a precursor for ATP and GTP. It may also work as a vasodilator (6). Inosine is known to stimulate DNA- and RNA synthesis in vitro (1). This is the reason for the claim that inosine can stimulate protein synthesis.


7.3 Effective route(s) of administration
I have not been able to obtain exact data on absorption of inosine. However, it seems like oral inosine has a limited absorption and injected inosine should produce higher plasma levels (13).


7.4 Effects in patients
Inosine has been shown to improve myocardial contractility force in patients with coronary heart disease (8,9,10). Also patients who have gone through transplant surgery have shown increased force of heart muscle contraction (11). If the same effect would occur in the healthy athlete the increased myocardial contractility force could lead to an improved blood flow and oxygen supply to the skeletal muscles. Inosine also increases oxygen/haemoglobin affinity. A large proportion of inosine introduced into the bloodstream goes directly into the red blood cells. Those cells then pick up increased amounts of oxygen when they pass through the lungs, and deliver it to the muscles (12). The effect can last 1-2 hours but is only evident with injected inosine (13). No successful studies have been published when oral inosine has been used.


7.5 Effects in athletes
There are only a few studies carried out on athletes. Williams and colleagues examined the effect of six grams inosine taken orally before a five kilometre run on a treadmill (3). Despite the high dosage, no beneficial effects were noticed. On the contrary, the athletes experienced decreased endurance. Other studies, both human and animal, support these results (4,5). Snider and co-workers investigated the effect of 100 mg inosine in combination with 100 mg Q-10 (ubiquinone), 500 mg cytochrome C and 200 IU vitamin E three times/day (6). The study was carried out over a four week period and no significant changes in blood glucose, lactate and free fatty acid concentration at exhaustion were observed.

A Romanian study, carried out by Dragan and co-workers, showed positive results. They gave 1 500 mg inosine/day to advanced weight lifters for six weeks (7). They observed an increase in free fatty acids which, in theory, could lead to better endurance and fatty acid oxidation. The conductivity in certain muscle nerves increased which theoretically could result in increased strength. The results are uncertain and questionable since they have not been reproduced.


7.6 Toxicity
Inosine is metabolised to uric acid and excreted with the urine (5). If the levels of uric acid are elevated (> 5 mg/dl) over a period of time, gout may arise. It is due to the deposition of crystalline uric acid in joints.


7.7 Conclusion
Inosine is not an effective supplement for athletes and it is toxic due to its ability to elevate uric acid levels in serum. High uric acid levels may lead to gout.


7.8 References
1. Ohyanagi H et al. Effects of nucleosides and a nucleotide on DNA and RNA syntheses by the salvage and de novo pathway in primary monolayer cultures of hepatocytes and hepatoma cells. J. Parenteral Enteral Nutr. 13(1), 51-58, 1989.
2. Sahlin K, Katz A. Hypoxaemia increases the accumulation of inosine monophosphate (IMP) in human skeletal muscle during submaximal exercise. Acta Physiol. Scand. 136(2), 193-198, 1989.
3. Williams et al. Effect of inosine supplementation on 3-mile treadmill run performance and VO2 peak. Med. Sci. Sports. Exerc. 22, 517-522, 1990.
4. Goldman B, Wheeler K, Williams M, Lombardo J. Roundtable: Popularized ergogenic aids. Natl. Strength Conditioning Assoc. J. 1, 10-14, 1989.
5. Kurtz TW et al. Liquid chromatographic measurements of inosine, hypoxantine, and xantine in studies of fructose induced degradation of adenine nucleotides in humans and rats. Clin. Chem. 32, 782, 1986.
6. Snider IP, Bazzarre TL, Murdoch SD, Goldfarb A. Effects of coenzyme athletic performance system as an ergogenic aid on endurance performance to exhaustion. International Journal of Sports Nutrition 2(3), 272-286, 1992.
7. Dragan I, Baroga M, Eremia N, Georgescu E. Studies regarding some effects of inosine in elite weightlifters. Romanian Journal of Physiology 30(1-2), 47-50, 1993.
8. Czarnecki W, Czarnecki A. Hemodynamic effects of inosine. A new drug for the failing human heart ? Pharmacol Res 21, 587-594, 1989.
9. de Jong JW, Czarnecki W, Ruzyllo W et al. Apparent inosine uptake by the human heart. Cardiovasc. Res. 23, 484-488, 1989.
10. Kipshidze NN et al. Indications for the use of inosine in myocardial infarction: Clinical and experimental study. Kardiologiia 18, 18-28, 1978.
11. Wickham JEA et al. Inosine in preserving renal function during ischemic renal surgery. Br. Med. J. 2, 173-174, 1978.
12. Nevins MS. Oxyhemoglobin equilibrium in ischemic heart disease. JAMA 229, 804-808, 1974.
13. Aviado DM. Inosine: A naturally occuring cardiotonic agent. Journal of Pharmacology 14 (suppl. 3), 47-71, 1983.


warto tez poczytac ten txt - niestety nie mam go pod reka, stad referencje:
Starling RD, Trappe TA, Short KR, et al. Effect of inosine supplementation on aerobic and anaerobic cycling performance. Med Sci Sports Ex 1996;28:1193–8.


podsoomowoojac - osobiscie nie podchodze do kwestii nazbyt entoozjastycznie

Wielkie dzięki. Rzeczywiście nie wygląda to zachęcająco.

udalo sie jednak odszookac na dysku badanie, do ktoorego podalam referencje

Starling, R. D., Trappe, T. A., Short, K. R., Sheffield-Moore, M., Jozsi, A. C., Fink, W. J., & Costill, D. L. (1996). The effect of inosine supplementation on aerobic and anaerobic cycling performance. Medicine and Science in Exercise and Sports, 28(5), Supplement abstract 487.

[Inosine is not an amino acid but is classified as a nucleoside. It is associated with the development of purines, nonprotein nitrogen compounds that have important roles in energy metabolism. It has been suggested that inosine may improve ATP production in the muscle and thus be of value to strength athletes. It is also thought to enhance oxygen delivery to the muscles which would benefit endurance athletes. There are no data to support these claims.]

Male competitive cyclists (N = 10) completed a Wingate Bike Test, a 30-min self-paced endurance cycling performance, and a constant load supramaximal sprint test to fatigue following five days of oral supplementation (5,000 mg/day) with inosine and a placebo.

It was found that inosine supplementation did not improve endurance or power (sprint) performance. It was observed that under some conditions, inosine supplementation might even be detrimental to performance.

Implication. Inosine supplementation does not appear to have beneficial effects on endurance or sprint performance.