Arginina - suplement przyszłości?

Mechanizmy anabolicznej aktywności argininy wyjaśniam bardzo dokładnie w mojej książce. Tam też przywołuję potwierdzające to badania. Zaproszę może Binia do tej dyskusji, bo to spec od wyszukiwania badań, więc ma pewnie w zanadrzu jakieś - potwierdzające anaboliczną aktywność argininy.

chętnie poczytam

bardzo ciekawe oprcowanie:

http://jn.nutrition.org/cgi/content/full/134/10/2888S

Supplement: Arginine Metabolism: Enzymology, Nutrition, and Clinical Significance
Potential Ergogenic Effects of Arginine and Creatine Supplementation1,2
Douglas Paddon-Jones, Elisabet Børsheim and Robert R. Wolfe3

Department of Surgery, The University of Texas Medical Branch and Metabolism Unit, Shriners Hospitals for Children, Galveston, TX 77550


Wartosciowy skrót:

The rationale for the use of nutritional supplements to enhance exercise capacity is based on the assumption that they will confer an ergogenic effect above and beyond that afforded by regular food ingestion alone. The proposed or advertised ergogenic effect of many supplements is based on a presumptive metabolic pathway and may not necessarily translate to quantifiable changes in a variable as broadly defined as exercise performance. L-arginine is a conditionally essential amino acid that has received considerable attention due to potential effects on growth hormone secretion and nitric oxide production. In some clinical circumstances (e.g., burn injury, sepsis) in which the demand for arginine cannot be fully met by de novo synthesis and normal dietary intake, exogenous arginine has been shown to facilitate the maintenance of lean body mass and functional capacity. However, the evidence that supplemental arginine may also confer an ergogenic effect in normal healthy individuals is less compelling. In contrast to arginine, numerous studies have reported that supplementation with the arginine metabolite creatine facilitates an increase in anaerobic work capacity and muscle mass when accompanied by resistance training programs in both normal and patient populations. Whereas improvement in the rate of phosphocreatine resynthesis is largely responsible for improvements in acute work capacity, the direct effect of creatine supplementation on skeletal muscle protein synthesis is less clear. The purpose of this review is to summarize the role of arginine and its metabolite creatine in the context of a nutrition supplement for use in conjunction with an exercise stimulus in both healthy and patient populations.



Godnym uwagi jest fakt dotyczacy róznic w wynikach samych badań, zaleznie od tego czy wykonywane były one na osoibach zdrowych, czy tez dotknietych jakąs przypadłoscią (np rpzległe poparzenia). Zapewne wynika to z faktu, iz arginina jest aminokwasem "warunkowo niezbednym". Stad też w moim przekonaniu fakt, że sama arginina posiada jakies ciekawe wlciwosci - nie zawsze musi oznacząc, ze zwiekszona jej podaż te walory zwielokrotni czy tez chociaz -nasili. Osobiscie - jako amator i laik co prawda - jestem zdania, że doraźne podawanie argininy w okresie okołotreningowym jest rozwiązaniem korzystnym. Nie pokładam niej jednak wielkich nadziei w kontekscie przypisywanych jej wlasciwosci anabolicznych. Nie zwykłem tez stosować jej - np codziennie, o innych porach niż okolotreningowe bo nie widze sensu. Jest to jednak moja osobista preferencja.

Zmieniony przez - faftaq w dniu 2009-07-27 10:05:22

Nie trzeba jej przypisywać właściwości anabolicznych, gdyż ta jest - po prostu - anabolikiem. Wyjaśniam to szczegółowo w moje książce. Inna sprawa: czy teoria przekłada się tutaj w dostatecznym stopniu na praktykę. Nie każdy hormon czy czynnik potencjalnie anaboliczny - podawany sportowcom - skutkuje przyrostem masy mięśniowej, na co dobitnego przykładu dostarczają chociażby hormony tarczycy.

Nieporozumienie -> kwestia terminologii, wyraziłem sie malo precyzyjnie. Chodzi mi o wykazanie praktycznych wlasciwosci anabolicznych argininy, które można byłoby wykazać w praktyce. Chodzi o banalne kwestie, jak np "wzrost beztluszczowej masy ciala".

Jasne!... Biniu coś wynalazł i jutro podeśle.
A z ciekawostek... Czy wiecie, że arginina jest jedynym anabolikiem stosowanym klinicznie w ciąży - w przypadku zbyt małej masy rozwojowej (hipoplazji) płodu?...

anabolicznie to działa tylko koks

A tak na serio to arginina, może być dla większej pompy i lepszego treningu ot co, żadnych magicznych przyrostów nie ma. Jak dla mnie to anabolicznie działa tylko kreatyna, reszta działa ale na papierze.

moze niekoniecznie Panowie z min 10 letnim stazem na hardcorowej silowni ale zawsze

milej lektury

nt J Sport Nutr Exerc Metab. 2008 Oct;18(5):493-508.Links
Creatine, arginine alpha-ketoglutarate, amino acids, and medium-chain triglycerides and endurance and performance.

Little JP, Forbes SC, Candow DG, Cornish SM, Chilibeck PD.
College of Kinesiology, University of Saskatchewan, Saskatoon, SK, Canada.
Creatine (Cr) supplementation increases muscle mass, strength, and power. Arginine a-ketoglutarate (A-AKG) is a precursor for nitric oxide production and has the potential to improve blood flow and nutrient delivery (i.e., Cr) to muscles. This study compared a commercial dietary supplement of Cr, A-AKG, glutamine, taurine, branched-chain amino acids, and medium-chain triglycerides with Cr alone or placebo on exercise performance and body composition. Thirty-five men (approximately 23 yr) were randomized to Cr + A-AKG (0.1 g . kg(-1) . d(-1) Cr + 0.075 g . kg(-1) . d(-1)A-AKG, n = 12), Cr (0.1 g . kg(-1) . d(-1), n = 11), or placebo (1 g . kg(-1) . d(-1) sucrose, n = 12) for 10 d. Body composition, muscle endurance (bench press), and peak and average power (Wingate tests) were measured before and after supplementation. Bench-press repetitions over 3 sets increased with Cr + A-AKG (30.9 +/- 6.6 +/- 34.9 +/- 8.7 reps; p < .01) and Cr (27.6 +/- 5.9 +/- 31.0 +/- 7.6 reps; p < .01), with no change for placebo (26.8 +/- 5.0 +/- 27.1 +/- 6.3 reps). Peak power significantly increased in Cr + A-AKG (741 +/- 112 +/- 794 +/- 92 W; p < .01), with no changes in Cr (722 +/- 138 +/- 730 +/- 144 W) and placebo (696 +/- 63 +/- 705 +/- 77 W). There were no differences in average power between groups over time. Only the Cr-only group increased total body mass (79.9 +/- 13.0 +/- 81.1 +/- 13.8 kg; p < .01), with no significant changes in lean-tissue or fat mass. These results suggest that Cr alone and in combination with A-AKG improves upper body muscle endurance, and Cr + A-AKG supplementation improves peak power output on repeated Wingate tests.



Nutrition. 2006 Sep;22(9):872-81. Links
Pharmacokinetics, safety, and effects on exercise performance of L-arginine alpha-ketoglutarate in trained adult men.

Campbell B, Roberts M, Kerksick C, Wilborn C, Marcello B, Taylor L, Nassar E, Leutholtz B, Bowden R, Rasmussen C, Greenwood M, Kreider R.
Exercise and Sport Nutrition Laboratory at the Center for Exercise, Nutrition, and Preventative Health Research, Department of Health, Human Performance, and Recreation, Baylor University, Waco, Texas, USA.
OBJECTIVE: We evaluated the pharmacokinetics, safety, and efficacy of l-arginine alpha-ketoglutarate (AAKG) in trained adult men. METHODS: Subjects parti****ted in two studies that employed a randomized, double-blind, controlled design. In study 1, 10 healthy men (30-50 y old) fasted for 8 h and then ingested 4 g of time-released or non-timed-released AAKG. Blood samples were taken for 8 h after AAKG ingestion to assess the pharmacokinetic profile of L-arginine. After 1 wk the alternative supplement was ingested. In study 2, which was placebo controlled, 35 resistance-trained adult men (30-50 y old) were randomly assigned to ingest 4 g of AAKG (three times a day, i.e., 12 g daily, n = 20) or placebo (n = 15). Parti****nts performed 4 d of periodized resistance training per week for 8 wk. At 0, 4, and 8 wk of supplementation the following tests were performed: clinical blood markers, one repetition maximum bench press, isokinetic quadriceps muscle endurance, anaerobic power, aerobic capacity, total body water, body composition, and psychometric parameters tests. Data were analyzed by repeated measures analysis of variance. RESULTS: In study 1, significant differences were observed in plasma arginine levels in subjects taking non-timed-release and timed-release AAKG. In study 2, significant differences were observed in the AAKG group (P < 0.05) for 1RM bench press, Wingate peak power, blood glucose, and plasma arginine. No significant differences were observed between groups in body composition, total body water, isokinetic quadriceps muscle endurance, or aerobic capacity. CONCLUSION: AAKG supplementation appeared to be safe and well tolerated, and positively influenced 1RM bench press and Wingate peak power performance. AAKG did not influence body composition or aerobic capacity.




Clin Physiol Funct Imaging. 2008 Sep;28(5):307-11. Epub 2008 May 28. Links
The effect of L-arginine administration on muscle force and power in postmenopausal women.

Fricke O, Baecker N, Heer M, Tutlewski B, Schoenau E.
Children's Hospital, University of Cologne, Cologne, Germany. [email protected]
Previously published data (J Bone Miner Res (2005); 20: 471) did not give evidence that the administration of the nitric oxide precursor L-arginine increases bone formation and decreases bone resorption in postmenopausal women. Data of this trial were reanalysed for putative effects of L-arginine on muscle mass and muscular function. Therefore, 11 females of the former study group (n=15; age 54.5+/-4.1 years; daily oral administration of 18 g L-arginine hydrochloride (equivalent of 14.2 g L-arginine) over 6 months) and 12 females of the control group (n=15; age 55.3+/-4.4 years; daily administration of 18 g dextrose over 6 months) were analysed for biomechanical parameters (MIGF, maximal isometric grip force; PJF, peak jump force; PJP, peak jump power) and for the cross-sectional muscle area (MA) and fat area (FA) at forearm and leg (calf) measured by peripheral quantitative computed tomography. The study was performed in a double-blind design. The assessment of muscular and biomechanical parameters was undertaken before and after 6 months of L-arginine versus placebo administration. L-arginine-supplemented females had a significant increase of PJF/kg in comparison with the control group. PJP/kg, MIGF, MA and FA were not significantly influenced by the administration of L-arginine. In conclusion, the administration of L-arginine increased maximal force in mechanographic analyses and may prevent a decline of muscle force in postmenopausal women.




Clin Nutr. 2008 Apr;27(2):189-95. Epub 2008 Mar 4. Links
Effect of amino acid supplementation on muscle mass, strength and physical function in elderly.

Borsheim E, Bui QU, Tissier S, Kobayashi H, Ferrando AA, Wolfe RR.
Department of Surgery, University of Texas Medical Branch, 815 Market Street, Galveston, TX 77550, USA. [email protected]
BACKGROUND & AIMS: With advancing age there is a gradual decline in muscle mass, strength and function. The aim of this study was to determine if regular intake of a nutritional supplement containing essential amino acids (EAA)+arginine could reverse these responses in elderly subjects. METHODS: Twelve glucose intolerant subjects (67.0+/-5.6 (SD) years, 7 females, 5 males) ingested 11 g of EAA+arginine two times a day, between meals for 16 weeks. Diet and activity were not otherwise modified. Lean body mass (DEXA) was measured every fourth week. Maximal leg strength was tested and functional tests were performed at week 0, 8, 12, and 16. RESULTS: Lean body mass (LBM) increased during the study (p=0.038). At week 12, the average increase in LBM was 1.14+/-0.36 (SE) kg (p<0.05 vs baseline), whereas at week 16, the increase was 0.60+/-0.38 kg (NS vs baseline). The lower extremity strength measure score (sum of individual knee flexors and extensors' one repetition maximum, n=10) was 127.5+/-21.8 kg at baseline, and average increase during the study was 22.2+/-6.1% (p<0.001). Improvements were also observed in usual gait speed (p=0.002), timed 5-step test (p=0.007), and timed floor-transfer test (p=0.022). CONCLUSION: Supplementation of the diet with EAA+arginine improves lean body mass, strength and physical function compared to baseline values in glucose intolerant elderly individuals.




J Nutr. 2006 Feb;136(2):538S-543S. Links
Amino acid mixture improves training efficiency in athletes.

Ohtani M, Sugita M, Maruyama K.
Department of Environmental Studies, Graduate School of Frontier Sciences, the University of Tokyo, Chiba, Japan. [email protected]
This review discusses some of the beneficial effects of a dietary amino acid supplement on muscle function, fatigue, and recovery in exercising athletes. The supplement, a mixture of amino acids that included the branched-chain amino acids, arginine and glutamine, was studied chronically at several daily dose levels for extended periods of time (10, 30, and 90 d). Outcome variables included physical measures of muscle strength, fatigue and damage, and blood indices of muscle damage and oxygen-carrying capacity. One beneficial effect of the amino acid supplement was a quicker recovery from the muscle fatigue that followed eccentric exercise training. A dose-response study of the amino acid mixture at 2.2, 4.4, and 6.6 g/d for 1 mo showed that at the highest dose, indices of blood oxygen-carrying capacity were increased and those of muscle damage were decreased at the end of the trial. When the amino acid mixture was given for 90 d to elite rugby players during training at a dose of 7.2 g/d, a blood-component analysis indicated improvements in the oxygen-carrying capacity of the blood. Together, the studies suggest that the amino acid supplement contributed to an improvement in training efficiency through positive effects on muscle integrity and hematopoiesis.





Nutrition. 2004 May;20(5):445-51. Links
Effect of beta-hydroxy-beta-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women.

Flakoll P, Sharp R, Baier S, Levenhagen D, Carr C, Nissen S.
Department of Health and Human Performance, Vanderbuilt University Medical Center, Nashville, Tennessee, USA. [email protected]
OBJECTIVE: With advancing age, there is a gradual loss of muscle mass, strength, and functionality. The current studies were conducted to determine whether a mixture of specific nutrients, arginine and lysine, which support protein synthesis, and beta-hydroxy-beta-methylbutyrate (HMB), which can slow protein breakdown, could blunt the gradual loss of muscle that occurs in the elderly, thus improving strength and functionality. METHODS: In double-blind studies conducted at two separate sites, women (mean 76.7 y) were randomized to a placebo group (n = 23) or an experimental treatment group (2 g beta-hydroxy-beta-methylbutyrate, 5 g arginine, and 1.5 g lysine daily; n = 27). RESULTS: After 12 wk, there was a 17% improvement in the "get-up-and-go" functionality test in the experimental group (-2.3 +/- 0.5 s) but no change in the placebo group (0.0 +/- 0.5 s; P = 0.002). The improvement in functionality also was reflected by increased limb circumference, leg strength, and handgrip strength (all P < 0.05) and positive trends in fat-free mass (P = 0.08). Whole-body protein synthesis, estimated with the (15)N-glycine tracer technique over a 24-h free-living period, increased approximately 20% in the experimental treatment group as opposed to the placebo group (P = 0.03). CONCLUSION: These studies indicated that daily supplementation of beta-hydroxy-beta-methylbutyrate, arginine, and lysine for 12 wk positively alters measurements of functionality, strength, fat-free mass, and protein synthesis, suggesting that the strategy of targeted nutrition has the ability to affect muscle health in elderly women.

Badanie pierwsze - fajne. Pozostałe - tak srednio, biorąc pod uwagę grupy na których były przeprowadzane, czy inne aplikowane razem z argininą susbtancje (np EAA).

Czy tak czy siak - wplyw argininy na siłe miesni - jest odczuwalny, nie wiem na ile jednak jest to dzialanie dorazne.

Z tegop co widzę wnioski z badań na sportowcach: suplementacja argininą nie ma wplywu na sklad i masę ciała...

Zmieniony przez - faftaq w dniu 2009-07-28 20:22:56

Wciąż potwierdzają się podobne wnioski - suplementy działają najlepiej na osoby mało wytrenowane lub ćwiczące rekreacyjnie. Ale też i takie osoby są właśnie głównymi ich konsumentami i czytelnikami tego forum.