Choć daleki jestem od straszenia ludzi aspartamem, to przyznać trzeba że są publikacje i badania wskazujące, że warto zachować umiar w wypadku stosowania tej substancji słodzącej. Choć aspartam jako związek nie zawiera niczego niezwykłego, wysoka jego konsumpcja może zaburzyć relację pomiędzy
fenyloalaniną, tyrozyną i waliną i może to mieć zdaniem niektórych badaczy negatywne konsekwencje.
Co do literatury tak na szybko:
Aspartame ingestion and headaches: a randomized crossover trial.
Van den Eeden SK, Koepsell TD, Longstreth WT Jr, van Belle G, Daling JR, McKnight B.
Source
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195.
Abstract
To examine whether ingestion of aspartame is associated with headaches, we conducted a double-blind crossover study using volunteers with self-identified headaches after using aspartame. Of the 32 subjects randomized to receive aspartame (approximately 30 mg/kg/d) and placebo in a two-treatment, four-period crossover design, 18 completed the full protocol, seven completed part of the protocol before withdrawing due to adverse effects, three withdrew for other reasons, two were lost to follow-up, one was withdrawn due to noncompliance, and one withdrew and gave no reason. Each experimental period was 7 days long. Subjects reported headaches on 33% of the days during aspartame treatment, compared with 24% on placebo treatment (p = 0.04). Subjects who were "very sure" prior to the study that aspartame triggered some of their headaches reported larger treatment differences (aspartame = 0.37 headache-days, placebo = 0.18 headache-days; p < 0.001) than subjects who were "somewhat sure" (aspartame = 0.29 headache-days, placebo = 0.22 headache-days; p = 0.51) or "not sure" (aspartame = 0.33 headache-days, placebo = 0.39 headache-days; p = 0.51). There was no significant treatment difference in the length or intensity of headaches or in the occurrence of side effects associated with the headaches. This experiment provides evidence that, among individuals with self-reported headaches after ingestion of aspartame, a subset of this group report more headaches when tested under controlled conditions. It appears that some people are particularly susceptible to headaches caused by aspartame and may want to limit their consumption.
Aspartame: clinical update.
Potenza DP, el-Mallakh RS.
Abstract
Since the introduction of aspartame into the American food supply in 1981, it has grown to become the most widely used and accepted artificial sweetener. However, recent published and unpublished reports of headaches, seizures, blindness, and cognitive and behavioral changes with long-term, high-dose aspartame may be cause for concern. Physician awareness of the present clinical and research status of aspartame is important.
Possible neurologic effects of aspartame, a widely used food additive.
Maher TJ, Wurtman RJ.
Source
Department of Pharmacology, Massachusetts College of Pharmacy, Boston 02115.
Abstract
The artificial sweetener aspartame (L-aspartyl-L-phenylalanyl-methyl ester), is consumed, primarily in beverages, by a very large number of Americans, causing significant elevations in plasma and, probably, brain phenylalanine levels. Anecdotal reports suggest that some people suffer neurologic or behavioral reactions in association with aspartame consumption. Since phenylalanine can be neurotoxic and can affect the synthesis of inhibitory monoamine neurotransmitters, the phenylalanine in aspartame could conceiveably mediate neurologic effects. If mice are given aspartame in doses that elevate plasma phenylalanine levels more than those of tyrosine (which probably occurs after any aspartame dose in humans), the frequency of seizures following the administration of an epileptogenic drug, pentylenetetrazole, is enhanced. This effect is simulated by equimolar phenylalanine and blocked by concurrent administration of valine, which blocks phenylalanine's entry into the brain. Aspartame also potentiates the induction of seizures by inhaled fluorothyl or by electroconvulsive shock. Perhaps regulations concerning the sale of food additives should be modified to require the reporting of adverse reactions and the continuing conduct of mandated safety research.
Adverse reactions to aspartame: double-blind challenge in patients from a vulnerable population.
Walton RG, Hudak R, Green-Waite RJ.
Source
Department of Psychiatry, Northeastern Ohio Universities College of Medicine, Youngstown.
Abstract
This study was designed to ascertain whether individuals with mood disorders are particularly vulnerable to adverse effects of aspartame. Although the protocol required the recruitment of 40 patients with unipolar depression and a similar number of individuals without a psychiatric history, the project was halted by the Institutional Review Board after a total of 13 individuals had completed the study because of the severity of reactions within the group of patients with a history of depression. In a crossover design, subjects received aspartame 30 mg/kg/day or placebo for 7 days. Despite the small n, there was a significant difference between aspartame and placebo in number and severity of symptoms for patients with a history of depression, whereas for individuals without such a history there was not. We conclude that individuals with mood disorders are particularly sensitive to this artificial sweetener and its use in this population should be discouraged.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC548217/
Fakt faktem jednak, aspartam jest aktualnie chyba najlepiej przebadaną substancją słodzącą i stosowany z umiarem jest raczej bezpieczny dla większości osób bezpieczny. Nie powinien być jednak poddawany obróbce termicznej (gotowanie, smażenie, pieczenie).
Nie polecam bezkrytycznego podejścia do sztucznych substancji słodzących, zwłaszcza takich z którymi związane są pewne kontrowersje.
Zmieniony przez - faftaq w dniu 2011-11-15 16:25:01 
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