Co na stawy?

Myślałem, że już wiem wszystko na temat tego produktu, jednakże dzisiaj doszła paczka i pojawił się następny problem. Mianowicie, na opakowaniu napisane jest, żeby zużyć do 30 dni. Puszka zawiera 400g proszku, więc jeśli bym brał 10g dziennie, spożyłbym to w ciągu 40 dni. Czy mógłbym brać np. 14g dziennie, abym zmieścił się w tym limicie 30 dni?

Możesz. Ja jak to kupię to będę walił od razu 20g,bo mam niemiłosiernie zniszczone kolana.Napiszesz po skończeniu czy coś zadziałało na Ciebie ?

Tak, jeśli zauważę jakieś istotne zmiany.

Tak przy okazji Faftaq masz swoją opinię czyli znasz jakieś konkretne badania nad MSM? Działanie równe gluk. i chron. czy może potwierdzone że działa?

Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis.

Usha PR, Naidu MU.

Department of Clinical Pharmacology and Therapeutics, Nizam's Institute of Medical Sciences, Hyderabad, India.
Abstract

OBJECTIVE: Glucosamine, classified as a slow-acting drug in osteoarthritis (SADOA), is an efficacious chondroprotective agent. Methylsulfonylmethane (MSM), the isoxidised form of dimethyl-sulfoxide (DSMO), is an effective natural analgesic and anti-inflammatory agent. The aim of this study was to compare the efficacy and safety of oral glucosamine (Glu), methylsulfonylmethane (MSM), their combination and placebo in osteoarthritis of the knee.

PATIENTS AND DESIGN: A total of 118 patients of either sex with mild to moderate osteoarthritis were included in the study and randomised to receive either Glu 500mg, MSM 500mg, Glu and MSM or placebo capsules three times daily for 12 weeks. Patients were evaluated at 0 (before drug administration), 2, 4, 8 and 12 weeks post-treatment for efficacy and safety. The efficacy parameters studied were the pain index, the swelling index, visual analogue scale pain intensity, 15m walking time, the Lequesne index, and consumption of rescue medicine.

RESULTS: Glu, MSM and their combination significantly improved signs and symptoms of osteoarthritis compared with placebo. There was a statistically significant decrease in mean (+/- SD) pain index from 1.74 +/- 0.47 at baseline to 0.65 +/- 0.71 at week 12 with Glu (p < 0.001). MSM significantly decreased the mean pain index from 1.53 +/- 0.51 to 0.74 +/- 0.65, and combination treatment resulted in a more significant decrease in the mean pain index (1.7 +/- 0.47 to 0.36 +/- 0.33; p < 0.001). After 12 weeks, the mean swelling index significantly decreased with Glu and MSM, while the decrease in swelling index with combination therapy was greater (1.43 +/- 0.63 to 0.14 +/- 0.35; p < 0.05) after 12 weeks. The combination produced a statistically significant decrease in the Lequesne index. All treatments were well tolerated.

CONCLUSION: Glu, MSM and their combination produced an analgesic and anti-inflammatory effect in osteoarthritis. Combination therapy showed better efficacy in reducing pain and swelling and in improving the functional ability of joints than the individual agents. All the treatments were well tolerated. The onset of analgesic and anti-inflammatory activity was found to be more rapid with the combination than with Glu. It can be concluded that the combination of MSM with Glu provides better and more rapid improvement in patients with osteoarthritis.

PMID: 17516722 [PubMed - in process]

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Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial.

Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF.

Southwest College Research Institute, Southwest College of Naturopathic Medicine and Health Sciences, Tempe, AZ 85282, USA. [email protected]
Abstract

OBJECTIVE: Osteoarthritis (OA) is the most common form of arthritis and the second most common cause of long-term disability among middle-aged and older adults in the United States. Methylsulfonylmethane (MSM) is a popular dietary supplement used as a single agent and in combination with other nutrients, and purported to be beneficial for arthritis. However, there is paucity of evidence to support the use of MSM.

METHODS: A randomized, double-blind, placebo-controlled trial was conducted. Fifty men and women, 40-76 years of age with knee OA pain were enrolled in an outpatient medical center. Intervention was MSM 3g or placebo twice a day for 12 weeks (6g/day total). Outcomes included the Western Ontario and McMaster University Osteoarthritis Index visual analogue scale (WOMAC), patient and physician global assessments (disease status, response to therapy), and SF-36 (overall health-related quality of life).

RESULTS: Compared to placebo, MSM produced significant decreases in WOMAC pain and physical function impairment (P<0.05). No notable changes were found in WOMAC stiffness and aggregated total symptoms scores. MSM also produced improvement in performing activities of daily living when compared to placebo on the SF-36 evaluation (P<0.05).

CONCLUSION: MSM (3g twice a day) improved symptoms of pain and physical function during the short intervention without major adverse events. The benefits and safety of MSM in managing OA and long-term use cannot be confirmed from this pilot trial, but its potential clinical application is examined. Underlying mechanisms of action and need for further investigation of MSM are discussed.

PMID: 16309928 [PubMed - indexed for MEDLINE]


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Czyli raczej dobre wyniki osiągano, tylko w pierwszym badaniu używano również glukozaminy która w wielu badaniach wychodziła że działa na równi z placebo, więc chyba tak w skrócie można powiedzieć że MSM działa lepiej niż glukozamina ale chyba szału też nie robi.
Dzięki Faf za badania.

ja jem gluko olimpu 1000 jedna tbl dz cały czas i jak przestaje to staw łokciowy zaczyna dokuczać, jak biorę jest ok wiec to na pewno nie placebo
ale też nie cudowny lek który naprawia raczej smaruje
działa po ok 1-2 miesiącach

djfafa - glukozaminie przypisuje sie rozne wlasciwosci, niektóre faktycznie moze wykazywac innych - już nie. Przegladajac publikacje na temat w/w mozna zauwazyc ze tym lepsze wyniki sie uzyskuje - im bardziej "złozony" jest zestaw testowanych substancji.