The following paragraph comes from a study that sent the peptide home with study participants for self-administration.
Vials were stored frozen until dispensed to the subjects, then kept at 4 C for 10 days at home. High performance liquid chromatographic analysis showed that the peptide was stable at 4 C for at least 2 weeks.
The following seems to indicate that GHRP-6 which is a simple peptide chain unlike IGF-1 which is more complex, is relatively resistant to degradation under the right circumstances at room temperature for almost five years.
The influence of the various buffer species (acetate, citrate, phosphate and borate) was shown to be different and the maximum stability of GHRP-6 was revealed to be in acetate buffer of pH 5.5-6.0. Degradation of GHRP-6 was greater in citrate-containing buffers than in acetate-containing ones. Furthermore, in the citrate-containing buffers, the higher buffer concentration caused greater degradation than the lower ones, but the concentration effect was negligible in acetate-containing buffers. Aqueous solution of GHRP-6 buffered with acetate (0.01 M, pH 5.5) showed a predicted t90% of 4.73 years at 20°C. - Degradation kinetics of growth hormone-releasing hexapeptide (GHRP-6) in aqueous solution, In Sik Ha… International Journal of Pharmaceutics Volume 144, Issue 1, 22 November 1996, Pages 91-97
NOTE: That the above study showing long-term (years) stability use peptides that had a base added to it (buffer) and then an acid was added to bring the pH to a middle stable range and hold it. Both the base (buffer) & acid must be present. Reconstituting w/ an acid alone will harm the peptide w/o a base present.
It is worth noting the characteristics of the primary aqueous solution we use to reconstitute these peptides:
Bacteriostatic Water for injection, USP is a sterile, nonpyrogenic preparation of water for injection containing 0.9% (9 mg/mL) of benzyl alcohol added as a bacteriostatic preservative. It is supplied in a multiple-dose container from which repeated withdrawals may be made to dilute or dissolve drugs for injection. The pH is 5.7 (4.5 to 7.0)
NOTE: the stability will no be nearly as long as buffer/acid reconstitutions because the pH will not hold for that long a period and depronation (movement of protons from one amino to another will occur. Storing in cold temperature will greatly help and the solution reconstituted w/ BW should be fine as long as the peptides are clinical grade (i.e. highly pure).
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