izotretinoina atakuje uklad odpornosciowy- badania
W skrocie po polsku: badania laboratoryjne wykazaly, ze izotretinoina hamuje dzialalnosc ukladu odpornosciowego.
W tym badaniu wyraznie podkreslono, ze bylo to jedno z dzialan niepozadanych przy leczeniu nowotworow.
Zdolnosc izotretinoiny przenikania do ukladu nerwowego jest zdaniem tych badaczy prawdopodobnie powodem dlugofalowych zmian neurologicznych u pacjentow; wywoluje m.in. chroniczne przemeczenie
(niemal wszyscy uzytkownicy forum i osoby ktore sie ze mna kontaktuja, rowniez ja sama, skarza sie na chroniczne przemeczenie po kuracji
Roaccutanem. lekarze przepisuja na to srodki antydepresyjne).
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In vitro analysis of isotretinoin has discovered it to be more immunosuppressive in rats that the drugs prescribed for that purpose: cyclosporin A and 6-mercaptopurin1(1). This immunosuppressant activity is realised through a reduction in the ability of T cells to proliferate in response to immune challenge.
The researchers commented that immune suppression was an undesired effect when using isotretinoin as a chemotherapeutic in cancer therapy. However, since isotretinoin is highly fat soluble and freely passes from the bloodstream into the brain, the authors concluded that isotretinoin may be a useful drug in treating autoimmune disorders of the nervous system. In particular, they drew attention to the possible use of isotretinoin to treat multiple schlerosis.
The lipophilic nature of isotretinoin and its ability to cross the blood-brain barrier and enter the nervous system may account for some of the long-term neurological problems experienced by patients who have taken isotretinoin for acne. Its obvious immunosuppressant activity may be a contributing factor in the chronic fatigue and immune disfunction of many post-isotretinoin patients.
(1) Vergelli, M., Olivotto, J., Castigli, E., Gran, B., Raimondi, L., Pirisino, R., Amaducci, L. and Massacesi, L. 1997. Immunosuppressive Activity of 13-cis-retinoic Acid in Rats: Aspects of Pharmacokinetics and Pharmacodynamics. Immunopharmacology. 37:191-197.