rhIL- 15 i ORAL IGF-1 - wtf??? %)

juz dawno nie siedze na us boardach wiec moze wypadlem z obiegu ale macie jakies info o

rhIL- 15 95% 150USD/mg /jak widac drogie w **** /

ORAL IGF-1 Capsule 30cap/vial, 150USD/vial, one day one capsule /w jaki sposob uzyskano aktywnosc przy podaniu doustnym? bo nie podejzewam ze przez metylacje /

bede zobowiazany

o widzicie nie skojarzylem ze to oratropin a sam kiedys o nim temat zakladalem

https://www.sfd.pl/ORAL_LR3_IGF-1_ciekawostka_-t187908.html

https://www.sfd.pl/ORATROPIN-1_sznasa_na_lr3_igf-1_w_Polsce__-t182116.html



a macie cos o tym drugim gownie? rhil-15?

edit: znalazlem cos l rea

"This is one of the newer drugs appearing on the bodybuilding scene that I would like to comment only briefly on. The human body produces several growth factors that are mediators and intermediates. In short this means they translate or decrease/increase the effect of hormones and other growth factors.

A study published in the Journal of Endocrinology in 1995 showed IL-15 doubled the rate of hypertrophy in skeletal muscle tissue. Interesting? Well the same study showed that stacking IL-15 with IGF-1 (insulin like growth factor-1; the stuff GH is converted into by the liver and other sites) increased muscular hypertrophy (excessive development/growth) by 500%. How is that for mediation?

I have known only a few athletes whom have utilized this stack, and to be honest, I have always believed (and seen that) freaks can be created even from those with below average genetics anyway. Yes, the results were amazing. The down side of IL-15 use is that lack of research. Some have speculated that IL-15 can trigger cancer cell growth. However, available research has not shown a connection between IL-15 and organ growth as of yet. I will not, at this point, explain reported cycles or use. There is not enough research as of yet concerning possible negative side effects. However as more research becomes available, you can bet I will be happy to share the reported results."

i jakies badania jablonskich z ktorych wynika ze dosc silnie zwieksza koncentracje cgmp i no2 i no3

Zmieniony przez - Kazam w dniu 2008-05-29 16:12:27

Ja tego nie wiem ale zastanawia mnie "uzytecznosc" takiego wynalazku. Jaki to ma sens? Przeciec podajac oralnie nie dostarczamy IGF-1 do okreslonych partii miesni ale do calego systemu. Ryzyko nadmiernego przerostu organow jest wiec duzo wieksze niz w przypadku iniekcyjnej formy. Nie wiem jak sie wytwarza "oralny" IGF ale znalazlem takie badania o myszach podjadajaych sobie IGF

Abstract

Insulin-like growth factor (IGF)-I is a polypeptide that mediates the growth-promoting action of growth hormone in postnatal animals. The present study was conducted to examine whether orally administered IGF-I would be absorbed into the general circulation and also whether ingested IGF-I would enhance the growth of whole body as well as internal organs, and tissues in 3-week-old ICR-strain female weanling mice. In experiment (Exp) 1, a total of 70 mice received IGF-I orally at 1 &#181;g&#183;g-1 in 0.2-ml PBS or the vehicle alone. Concentrations of IGF-I and glucose in heart blood were measured after killing 5 animals in each group every fourth hour during a 24-hour period. In Exp 2, a total of 40 mice received oral IGF-I administration at 1 &#181;g&#183;g-1 or vehicle every third day beginning from day 0 for a 13-day period. Half the animals were killed at day 7 and the other half at day 13. Weights of whole body and organs/tissues (small intestine, liver, thigh muscle, and brain) were measured every day and at slaughter, respectively. In Exp 1, following the oral IGF-I administration, serum IGF-I concentration increased at hour 4 (p < 0.01) and returned to the hour 0 level by hour 8, whereas glucose concentration was lowest at hour 4 and returned to the hour 0 level by hour 16. In the PBS-fed group, neither IGF-I nor glucose concentration changed during the 24-hour period. In Exp 2, weight of small intestine increased (p < 0.05) in response to the oral IGF-I, whereas weights of liver and thigh muscle of the IGF-I-fed group were greater (p < 0.01) and tended to be greater (p = 0.06), respectively, than those of the PBS-fed only at day 13. However, brain weight and serum concentrations of IGF-I and IGF-II were not affected by oral IGF-I administration. Results suggest that although orally administered IGF-I mainly acts at the intestine, a portion of ingested IGF-I is absorbed into the general circulation to enhance the growth of selective organs/tissues in weanling mice.

Copyright &#169; 2006 S. Karger AG, Basel

f1.08 iniekcyjne igf-1 rowniez dziala obwodowo na organizm, przynajmniej te ktore stosuje sie w bb.

Wiem, ale chyba nie az w tak duzym stopniu poniewaz czesc IGF od razu zwiaze sie z komorkami w miesniach w obrebie iniekcji. W przypadku oralnego podania IGF bedzie sie wiazac pewnie z kazda czescia organizmy w mniej wiecej rownym stopniu...a ze miejscem "dystrybucji" bedzie zoladek to wcale bym sie nie zdziwil gdyby wiekszosc towaru wiazala sie od razu z "bebechami".

większy żołądek - większe ssanie..

No i wieksza watroba = wiecej koksu mozna zrec

perpetum mobile

Wiem, ale chyba nie az w tak duzym stopniu poniewaz czesc IGF od razu zwiaze sie z komorkami w miesniach w obrebie iniekcji.

mylisz sie. zreszta o jakim rodzaju igf-1 mowisz?

Nie rozumiem...a ile jest "rodzajów" IGF-1? Chodzi ci o "media grade" i "receptor grade"? Bo chyba to czy jest to lr3 czy "naturalny" IGF-1 nie ma znaczenia. Zreszta odchodzimy od tematu chyba bo nikt z nas nie wie nic wiecej o tym oralnym IGF. Powiedz lepiej czemu uwazasz ze injekcyjna forma bedzie rownie mocno powiekszac bebechy jak oralna?(przy tej samej dawce) Logika podpowiada mi ze skoro wstrzykujemy w miesien to wiekszosc IGF zwiaze sie z komorkami(receptorami) i tylko to co pozostanie "wolne" bedzie krazyc po organizmie.(gdyby bylo inaczej to miejsce iniekcji nie mialo by znaczenia). Jak podamy doustnie to z czym ma sie wiazac te IGF w zoladku? IMO rozejdzie sie z krwia po wszystkich organach.



Zmieniony przez - F1.08 w dniu 2008-05-28 16:09:04

bzdury piszesz, wlasnie ma znaczenie czy igf-1 jest krotki czy dlugi. ale to nie na temat.

Kazam mowa o ORATROPIN-1. Troche do poczytania:


The first ever Cell-Mediated&#8482; Oral IGF-1 Long R3

Yes, you read it right, real Recombinant IGF-1. This is the only real IGF-1 product on the market. Don&#8217;t be fooled by all these IGF-1 sprays and precursor products that do not really contain IGF-1 to begin with.

This is the first pharmaceutical grade Cell-Mediated ORAL IGF-1 supplement known to man.


Due to the precise, delicate and expensive manufacturing of this product, we will only be stocking 167 kits our first production. We will be taking Pre-Orders in 2 weeks. So don't miss out.....order now to make sure you get one of the first batches. If you don't, you may have to wait up to 2 weeks for the next production.

Cell-Mediated&#8482;
IGF-1 Long R3 (for oral use)
100% Bioavailability, Orally Active, Sustained 24-48 hours
Each kit contains:
600mcg IGF-1 Long R3
15 individually sealed oral syringes for ease in daily dosing,
no measurements, no hassles.
Each oral syringe contains:
40mcg IGF-1 Long R3 sustained 24-48 hrs
0.5 cc's (0.661g) Oratropin-1&#8482; Long R3



Releasing for Purchase Feb. 2005






Competitive bodybuilding demands have always pushed body enhancement research and discovery to the next level. The potent anabolic effect of IGF-1 (Insulin-like Growth Factor) is no secret amongst the Pros. As a matter of fact, studies have shown that the anabolic growth commonly desired by supplementing with HGH (Human Growth Hormone) is the result of the increase of IGF-1 production. The problem is that the current available forms of IGF-1 are very limiting and mostly ineffective. Bodybuilders have been anxiously awaiting the next leap in science to bring them a better, easily attainable form of IGF-1. *** has developed the solution, Oratropin-1&#8482;.

This product that we are offering will be the most talked about supplement introduction of its time. We know this product is not only groundbreaking and milestone setting in the muscle building supplement industry, but will define the direction of overall nutritional supplementation bringing us into the Next Generation of Nutritional Science. Simply put, it is unsurpassed in comparison. Now that the shelves have been cleared of all middle-of-the-road prohormone supplements and at the same time all the wanna-be-muscle supplement manufacturers it is time for the next era of true muscle development science to unfold. This product is in no way one of the existing infamous "commodity" muscle formulas or a "me-too-type" protein drink. There is NO other prior formula or product like this. Because of our state-of-the-art patented delivery method, our formula will prove to be far more superior when compared with other inferiorly produced "commodity" muscle supplements.


Ground Breaking Technology

*** utilizes a technology that is clinically proven to mimic injection yielding higher bioavailability and non-degradation of the IGF-1. Current clinical studies have shown this technology to achieve near 100% bioavailability and prove to be sustained between 24-48 hours. The problem with IGF-1 is that it has only a half-life in the blood for 15-20 minutes and is not biologically active in oral administration. IGF-1 has poor to no absorption orally.

Oratropin-1&#8482; Long R3 is a composition that delivers IGF-1-Long R3, including other similar large peptides, to the blood. Signaling occurs from specific Insulin and Insulin-Like Growth Factor (IGF-1) receptors that regulate and transcribe the message allowing for site-specific receptor binding. Oratropin-1&#8482; utilizes an oral bioavailability delivery technology to deliver IGF-1 Long R3 into the portal blood allowing a sustained, pulsatile delivery resulting in a better utilization and potentially safer form of IGF-1 administration (in comparison to injection).

Because of this pulsatile motion and slow absorption into the blood, IGF-1 can have a longer half-life per dose. The rate Oratropin-1&#8482; mediates through the cell replicates the natural IGF-1 secretion. This allows Oratropin-1&#8482; to deliver at a constant equilibrium and sustained longer half-life. Also, Oratropin-1&#8482; will not be overdosed in the blood because it will effectively replicate natural cell mediation and the rate of diffusion into the blood will not "spike" blood plasma IGF-1 levels where IGF-1 is active (IGF-1 is only active in circulatory blood)

Let's face it; your body can only utilize so much IGF-1 in a given time. Oratropin-1&#8482; utilizes every Molar amount of the IGF-1 Long R3 because it is cell-mediated&#8482;. Cell-mediated&#8482; Oratropin-1&#8482; maximizes the mg/serving of the IGF-1 Long R3 and has fewer side effects.

This is one of those few instances where our technology is actually BETTER than injection.

Because of the recent pro-hormone/steroid ban, there is a need for a muscle-building supplement that is as good as 4-AD, 1-AD and 1-Testosterone. IGF-1 Long R3 at 100% bioavailability and 24-48 hour sustainability orally, will be better than any pro-hormone/steroid and even will be better than IGF-1 Long R3 injection because the sustainability is much longer with fewer side effects.

Benefits of IGF-1 Supplementation

There are many functionalities of IGF-1 in the human body including increased amino acid transport to cells, increased glucose transport, increased protein synthesis, decreased protein degradation and increased RNA synthesis. Active IGF-1 responds differently in different types of tissues. The key area of interest in IGF-1 studies is new muscle cell generation. In early human developmental phases, IGF-1 is responsible for the natural muscle growth that occurs. One response relative to muscle growth is the effective stimulation of muscle cell proteins and associated cell components. One of the most definitive effects of IGF-1 supplementation is its ability to cause hyperplasia. Hyperplasia is the actual splitting of cells which signifies actual muscle cell replication.

In adulthood, we reach a plateau in muscle cell count. Weight training will effectively increase the size of these pre-existing cells but still will have its limitations in effective muscle gain. IGF-1 supplementation will actually increase the number of muscle cells present in the tissue. Throughout active muscle training combined with IGF-1 supplementation, you can create the added benefit of larger, increased muscle cell counts. So in a way you are able to manipulate your genetic capabilities in relation to muscle tissue and cell generation. IGF-1 will distinctively define the number of various types of cells present in the body. On a genetic level it has the potential to alter your capacity to build superior muscle density and design.

When IGF-1 levels are increased, protein synthesis is increased along with amino acid absorption. IGF-1 will function as a source of energy and mobilize fat for use as energy in adipose tissue. IGF-1 response within lean tissue will prevent insulin from transporting glucose across cell membranes. The result of this activity will be a switch within the cells to burning fat as a source of energy, therefore causing significant fat cell decrease.

Although we have focused more on muscle cell development benefits and fat loss, there are many more cell growth and regeneration benefits IGF-1 has to offer including vital organ repair and growth, repair of injured nerve and muscle tissue, reduced cholesterol and normalized blood pressure, immune system strengthening, anti-aging benefits due to DNA damage repair and overall body repair leaving a new found vitality.



Oral vs. Injection

Current methods of IGF-1 delivery rely on injection to maximize dosage and to ensure no degradation of the compound occurs. Current injections of IGF-1 can only bind a quantitative amount dependent on the receptor availability and half-life of the IGF-1 per injected dose. Because a needle penetrating the cell surface bypasses cell-mediated endocytosis, there's no natural cell diffusion to control the absorption into portal blood. Currently, the only effective forms of IGF injections include IGF-1 Long R3 Media and Receptor grades. As a matter of fact, there have been recent findings proving that unregulated levels of IGF-1 in the bloodstream can put an individual at risk of dysphasia and stomach enlargement due to IGF-1 overdose triggered by a spike in blood plasma levels. Our Oratropin-1&#8482; formulation eliminates this risk with its unique and precise systematic release of IGF-1 Long R3 into the bloodstream during the 24-48 hour time frame of absorption. When blood levels reach a point of saturation, administration temporarily stops and then resumes when levels reach safer concentrations.

In layman's terms, injection administration causes an unregulated release of IGF-1 Long R3 into the bloodstream, which has higher associated risks leaving significant safety concerns. Oratropin-1&#8482; safely administers IGF-1 Long R3 into the bloodstream for a longer period of time.

With better utilization, Oratropin-1&#8482; proves to be more effective and holds a significantly less chance of overdose in the blood. This fact along with completely eliminating the painful daily injections required are only a few of the advantages Oratropin-1&#8482; holds over current IGF-1 injections.

We all know that oral IGF-1 is virtually impossible, well actually it is. It is a known fact; peptides of this nature will always loose integrity once entering the human digestive system. Although, many do not talk about some of the dangers of site injection related to stomach enlargement and blood plasma level spikes, it does not mean that these issues do not exist. Our formula effectively administers doses of IGF-1 into the bloodstream, yet has the capability of shutting off distribution when levels reach too high of a blood level content (blood plasma spikes). Several hours later, when levels have reached a safer ratio, administration will continue to restore and amplify existing blood levels of IGF-1. Clinical trials have already verified and further supported our claims of 24 hours consistent, sustained blood levels of IGF-1...........we will further support these claims with our most current clinical findings of 48 hour blood level verification. This means that even with the most trusted injectible forms, you can never completely achieve the potential of our formulation which literally allows for overlapping/double dose administration of IGF-1 Long R3 into the bloodstream. No fluctuations in levels to worry about ever again, no calculations for your next administration due to shortly sustained blood levels of IGF to worry about.



Zmieniony przez - -SHIELD- w dniu 2008-05-28 16:32:44

dzięki za info, będzie co czytać :)