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"On the contrary, Insulin will potentiate the effectiveness of GH secretion via GHRH/GHRP.
Insulin induced hypoglycemia via ITT (Insulin Tolerance Test) or insulin/ghrh stimulation unequivocally results in a greater GHRH mediated GH response.
This action is mediated via non GHRH pathway (direct decrease in Somatostatinergic tone and/or the possibility of endogenous Ghrelin/GHRP secretion.)
It has been used as the
gold standard for determination of GH deficiency long before the switch to safer GH stimulation (anti somatostatinergic) testing alternatives such as Arginine.
At various doses of .05 U/kg - 1 U/kg I.V.(5U and 10U per 100kg person) insulin has been documented in attenuating Somatostatin mediated GH suppression to concurrent (as well as successive) GHRH doses ranging anywhere from 30 min pre to 120 min post GHRH administration).
As far as GHRH goes, standard physiological and common BB insulin doses have a documented positive impact on induced GH secretion all within the questioned window.
Exogenous GHRP should not be affected negatively by insulin dosage with respect to secretion given the method of its (insulin's) proposed actions on both hypothalamus and pituitary along with speculation that insulin may itself be responsible for endogenous ghrelin/GHRP secretion as well.
Take Care.
*References take from the below study along with various additional study reference citations within. See: (4, 11, 13, 14, 15):
The role of endogenous GHRH in arginine-, insulin-, clonidine- and l-dopa-induced GH release in normal subjects
K Hanew and A Utsumi
Zmieniony przez - eugeno w dniu 2014-06-19 23:38:53 "
Zmieniony przez - eugeno w dniu 2014-06-19 23:44:35