solaros
Różeniec górski (Rhodiola rosea)
'Roślina lecznicza: W związku z udowodnieniem bardzo korzystnych własności leczniczych, rozpowszechnia się uprawa różańca górskiego dla pozyskania surowca.
Surowiec zielarski: kłącze z korzeniami. Zawiera ogromną ilość substancji czynnych: fenoloalkohol, glikozydy salidrozydu, rozarin, rozawin, rozin, liczne flawonoidy, fenolokwasy, kwasy organiczne (bursztynowy, cytrynowy, jabłkowy, szczawiowy), garbniki, tłuszcze, wosk, steryny, oksykumarynę, cukry i wiele innych. Z kłącza i korzeni wytwarza się nalewkę Rhodiolae fluidum i preparat Rodozin. Zioło to wchodzi w skład preparatu Meteo - na dolegliwości pogodowe.
Działanie: pobudzające (podwyższa sprawność organizmu), wzmacniające i adaptogenne (zwiększa wytrzymałość organizmu na stres i inne niekorzystne czynniki środowiska, zwiększa odporność na choroby)'
http://pl.wikipedia.org/wiki/Różeniec_górski
'Rhodiola zaliczana jest do tzw. adaptogenów, czyli roślin wzmacniających odporność organizmu na fizyczny i psychiczny stres, jak również jego skutki. Oprócz wielu interesujących właściwości tej rośliny, należy wspomnieć o kilku:
- większa odporność na choroby poprzez swoje właściwości immunostymulujące.
-Chroni wątrobę przed substancjami toksycznymi.
-Poprawia nastrój, wpływa pozytywnie na poprawę pamięci.
-Wykazuje działanie antyoksydacyjne.
-Wykazuje właściwości przeciwbólowe.
-Pobudza witalność seksualną.
U osób będących pod wpływem stresów, zwiększa poziom serotoniny i dopaminy w mózgu, obniżając jednocześnie poziom hormonów nadnerczy (kortyzolu i glikokortykosterydów), wytwarzanych w nadmiarze w sytuacji stresowej.
Dzięki zawartości opioidów endogennych, zmniejsza szkodliwy wpływ stresów na mięsień sercowy, zapobiega arytmii i miejscowemu niedokrwieniu.
Stymuluje produkcję insuliny oraz zwiększa wrażliwość komórek na insulinę, dzięki czemu obniża poziom cukru we krwi.
Posiada właściwości przeciwnowotworowe poprzez zwiększenie odporności organizmu.
Składniki aktywne, takie jak: rozawina i salidrozydy, podwyższając poziom serotoniny w mózgu, zmniejszają objawy depresji.
Podsumowując, Rhodiola rosea może pomóc w zachowaniu dobrej kondycji fizycznej i psychicznej oraz sił witalnych do sędziwych lat.'
Prof. Valeria Sedlak-Vadoc: "Natural help form Exotic Places"
Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty.
The aim of this study was to investigate the effect of repeated low-dose treatment with a standardized extract SHR/5 of rhizome Rhodiola rosea L, (RRE) on fatigue during night duty among a group of 56 young, healthy physicians. The effect was measured as total mental performance calculated as Fatigue Index. The tests chosen reflect an overall level of mental fatigue, involving complex perceptive and cognitive cerebral functions, such as associative thinking, short-term memory, calculation and ability of concentration, and speed of audio-visual perception. These parameters were tested before and after night duty during three periods of two weeks each: a) a test period of one RRE/placebo tablet daily, b) a washout period and c) a third period of one placebo/RRE tablet daily, in a double-blind cross-over trial. The perceptive and cognitive cerebral functions mentioned above were investigated using 5 different tests. A statistically significant improvement in these tests was observed in the treatment group (RRE) during the first two weeks period. No side-effects were reported for either treatment noted. These results suggest that RRE can reduce general fatigue under certain stressful conditions.
http://www.ncbi.nlm.nih.gov/pubmed/11081987
diwe grupy
-placebo
-grupa przyjmujaca RR
badano:zmęczenie psychiczne,spostrzegawcze i poznawcze funkcje mozgu - tj. myslenie,zapamietywanie,liczenie,koncentracja
wniosek:
o grupy stosujacej RR zauwazono znaczna poprawe tych funkcji - co swiadczy o tym ze Rhodiola rosea moze okazac sie pozytecznym suplementem zapobiegajacym ogolnemu zmeczeniu czy pomocna w warunkach stresowych.
A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work.
A randomized, double-blind, placebo-controlled, parallel-group clinical study with an extra non-treatment group was performed to measure the effect of a single dose of standardized SHR-5 Rhodiola rosea extract on capacity for mental work against a background of fatigue and stress. An additional objective was to investigate a possible difference between two doses, one dose being chosen as the standard mean dose in accordance with well-established medicinal use as a psychostimulant/adaptogen, the other dose being 50% higher. Some physiological parameters, e.g. pulse rate, systolic and diastolic blood pressure, were also measured. The study was carried out on a highly uniform population comprising 161 cadets aged from 19 to 21 years. All groups were found to have very similar initial data, with no significant difference with regard to any parameter. The study showed a pronounced antifatigue effect reflected in an antifatigue index defined as a ratio called AFI. The verum groups had AFI mean values of 1.0385 and 1.0195, 2 and 3 capsules respectively, whilst the figure for the placebo group was 0.9046. This was statistically highly significant (p < 0.001) for both doses (verum groups), whilst no significant difference between the two dosage groups was observed. There was a possible trend in favour of the lower dose in the psychometric tests. No such trend was found in the physiological tests.
http://www.ncbi.nlm.nih.gov/pubmed/12725561
badano 3 grupy:
-placebo
-grupe przyjmujaca RR
-grupe przyjmujaca RR o 50% wiecej niz poprzednia
wnioski:
wedlug anti fatigue index (indeks antyzmeczeniowy?)
u grupy placebo zmeczenie bylo o 20-30% wieksze
A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen.
The objective was to investigate the stimulating and normalizing effect of the adaptogen Rhodiola rosea extract SHR-5 in foreign students during a stressful examination period. The study was performed as a double-blind, randomized and placebo-controlled with low repeated dose regime. The study drug and the placebo were taken for 20 days by the students during an examination period. The physical and mental performance were assessed before and after the period, based on objective as well as on subjective evaluation. The most significant improvement in the SHR-5 group was seen in physical fitness, mental fatigue and neuro-motoric tests (p <0.01). The self-assessment of the general well-being was also significantly (p < 0.05) better in the verum group. No significance was seen in the correction of text tests or a neuro-muscular tapping test. The overall conclusion is that the study drug gave significant results compared to the placebo group but that the dose level probably was suboptimal.
http://www.ncbi.nlm.nih.gov/pubmed/10839209
w porownaniu do grupy placebo - grupa przyjmujaca RR wykazala sie lepsza sprawnoscia fizyczna,mniejszym zmeczeniem umyslowym i polepszonym samopoczuciem
Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression.
The objective of this study was to assess the efficacy and safety of standardized extract SHR-5 of rhizomes of Rhodiola rosea L. in patients suffering from a current episode of mild/moderate depression. The phase III clinical trial was carried out as a randomized double-blind placebo-controlled study with parallel groups over 6 weeks. Participants, males and females aged 18-70 years, were selected according to DSM-IV diagnostic criteria for depression, the severity of which was determined by scores gained in Beck Depression Inventory and Hamilton Rating Scale for Depression (HAMD) questionnaires. Patients with initial HAMD scores between 21 and 31 were randomized into three groups, one of which (group A: 31 patients) received two tablets daily of SHR-5 (340 mg/day), a second (group B: 29 patients) received two tablets twice per day of SHR-5 (680 mg/day), and a third (group C: 29 patients) received two placebo tablets daily. The efficacy of SHR-5 extract with respect to depressive complaints was assessed on days 0 and 42 of the study period from total and specific subgroup HAMD scores. For individuals in groups A and B, overall depression, together with insomnia, emotional instability and somatization, but not self-esteem, improved significantly following medication, whilst the placebo group did not show such improvements. No serious side-effects were reported in any of the groups A-C. It is concluded that the standardized extract SHR-5 shows anti-depressive potency in patients with mild to moderate depression when administered in dosages of either 340 or 680 mg/day over a 6-week period.
http://www.ncbi.nlm.nih.gov/pubmed/17990195
badano wplyw RR na osoby cierpiace na łagodna lyb umierkowaną depresje
byly 3 grupy
-placebo
-grupa przyjmujaca RR w dawce 340mg/dzien
-grupa przyjmujaca RR w dawce 680mg/dzien
wyniki po 6-ciu tygodniach:
u grup przyjmujacych RR znaczaco poprawila sie emeocjonalna niestabilznosc czy objawy depresji zlagodnialy
A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue.
The aim of the study was to assess the efficacy of the standardised extract SHR-5 of roots of Rhodiola Rosea L. in the treatment of individuals suffering from stress-related fatigue. The phase III clinical trial took the form of a randomised, double-blind, placebo-controlled study with parallel groups. Participants, males and females aged between 20 and 55 years, were selected according to the Swedish National Board of Health and Welfare diagnostic criteria for fatigue syndrome. A total of 60 individuals were randomised into two groups, one ( N = 30) of which received four tablets daily of SHR-5 extract (576 mg extract/day), while a second ( N = 30) received four placebo tablets daily. The effects of the extract with respect to quality of life (SF-36 questionnaire), symptoms of fatigue (Pines' burnout scale), depression (Montgomery -Asberg depression rating scale - MADRS), attention (Conners' computerised continuous performance test II - CCPT II), and saliva cortisol response to awakening were assessed on day 1 and after 28 days of medication. Data were analysed by between-within analyses of variance. No serious side effects that could be attributed to the extract were reported. Significant post-treatment improvements were observed for both groups (placebo effect) in Pines' burnout scale, mental health (SF-36), and MADRS and in several CCPT II indices of attention, namely, omissions, commissions, and Hit RT SE. When the two groups were compared, however, significant effects of the SHR-5 extract in comparison with the placebo were observed in Pines' burnout scale and the CCPT II indices omissions, Hit RT SE, and variability. Pre- VERSUS post-treatment cortisol responses to awakening stress were significantly different in the treatment group compared with the control group. It is concluded that repeated administration of R. ROSEA extract SHR-5 exerts an anti-fatigue effect that increases mental performance, particularly the ability to concentrate, and decreases cortisol response to awakening stress in burnout patients with fatigue syndrome.
http://www.ncbi.nlm.nih.gov/pubmed/19016404
byly dwie grupy
-placebo
-grupa przyjmujaca extraxt z RR w dawce 576mg/dzien
efekty po 28dniach:
w porownaniu do grupy placebo - u grupy przyjmujacej RR zauwazono spadek zmeczenia co skutkowalo polepszeniem pracy umyslowej,polepszeniem koncentracji i zmniejszeniem poziomu kurtyzolu
Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice.
Rhodiola rosea L., or 'golden root', is a popular plant in traditional medicine in Eastern Europe and Asia, with a reputation for improving depression, enhancing work performance, eliminating fatigue and treating symptoms of asthenia subsequent to intense physical and psychological stress. Due to these therapeutic properties, R. rosea is considered to be one of the most active adaptogenic drugs. To confirm and extend results obtained in the few preclinical and clinical studies available in English language journals, the purpose of the present study was to re-investigate the effects produced by a single oral administration of an R. rosea hydroalcohol extract (containing 3% rosavin and 1% salidroside) on the central nervous system in mice. The extract was tested on antidepressant, adaptogenic, anxiolytic, nociceptive and locomotor activities at doses of 10, 15 and 20 mg/kg, using predictive behavioural tests and animal models. The results show that this R. rosea extract significantly, but not dose-dependently, induced antidepressant-like, adaptogenic, anxiolytic-like and stimulating effects in mice. This study thus provides evidence of the efficacy of R. rosea extracts after a single administration, and confirms many preclinical and clinical studies indicating the adaptogenic and stimulating effects of such R. rosea extracts. Moreover, antidepressant-like and anxiolytic-like activities of R. rosea were shown in mice for the first time.
http://www.ncbi.nlm.nih.gov/pubmed/17072830
podawanie myszom extraktu z RR wykazalo wlasciwosci antydepresyjne,adaptogenne i pobudzajace
Zmieniony przez - solaros w dniu 2011-02-11 02:07:17
'Roślina lecznicza: W związku z udowodnieniem bardzo korzystnych własności leczniczych, rozpowszechnia się uprawa różańca górskiego dla pozyskania surowca.
Surowiec zielarski: kłącze z korzeniami. Zawiera ogromną ilość substancji czynnych: fenoloalkohol, glikozydy salidrozydu, rozarin, rozawin, rozin, liczne flawonoidy, fenolokwasy, kwasy organiczne (bursztynowy, cytrynowy, jabłkowy, szczawiowy), garbniki, tłuszcze, wosk, steryny, oksykumarynę, cukry i wiele innych. Z kłącza i korzeni wytwarza się nalewkę Rhodiolae fluidum i preparat Rodozin. Zioło to wchodzi w skład preparatu Meteo - na dolegliwości pogodowe.
Działanie: pobudzające (podwyższa sprawność organizmu), wzmacniające i adaptogenne (zwiększa wytrzymałość organizmu na stres i inne niekorzystne czynniki środowiska, zwiększa odporność na choroby)'
http://pl.wikipedia.org/wiki/Różeniec_górski
'Rhodiola zaliczana jest do tzw. adaptogenów, czyli roślin wzmacniających odporność organizmu na fizyczny i psychiczny stres, jak również jego skutki. Oprócz wielu interesujących właściwości tej rośliny, należy wspomnieć o kilku:
- większa odporność na choroby poprzez swoje właściwości immunostymulujące.
-Chroni wątrobę przed substancjami toksycznymi.
-Poprawia nastrój, wpływa pozytywnie na poprawę pamięci.
-Wykazuje działanie antyoksydacyjne.
-Wykazuje właściwości przeciwbólowe.
-Pobudza witalność seksualną.
U osób będących pod wpływem stresów, zwiększa poziom serotoniny i dopaminy w mózgu, obniżając jednocześnie poziom hormonów nadnerczy (kortyzolu i glikokortykosterydów), wytwarzanych w nadmiarze w sytuacji stresowej.
Dzięki zawartości opioidów endogennych, zmniejsza szkodliwy wpływ stresów na mięsień sercowy, zapobiega arytmii i miejscowemu niedokrwieniu.
Stymuluje produkcję insuliny oraz zwiększa wrażliwość komórek na insulinę, dzięki czemu obniża poziom cukru we krwi.
Posiada właściwości przeciwnowotworowe poprzez zwiększenie odporności organizmu.
Składniki aktywne, takie jak: rozawina i salidrozydy, podwyższając poziom serotoniny w mózgu, zmniejszają objawy depresji.
Podsumowując, Rhodiola rosea może pomóc w zachowaniu dobrej kondycji fizycznej i psychicznej oraz sił witalnych do sędziwych lat.'
Prof. Valeria Sedlak-Vadoc: "Natural help form Exotic Places"
Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty.
The aim of this study was to investigate the effect of repeated low-dose treatment with a standardized extract SHR/5 of rhizome Rhodiola rosea L, (RRE) on fatigue during night duty among a group of 56 young, healthy physicians. The effect was measured as total mental performance calculated as Fatigue Index. The tests chosen reflect an overall level of mental fatigue, involving complex perceptive and cognitive cerebral functions, such as associative thinking, short-term memory, calculation and ability of concentration, and speed of audio-visual perception. These parameters were tested before and after night duty during three periods of two weeks each: a) a test period of one RRE/placebo tablet daily, b) a washout period and c) a third period of one placebo/RRE tablet daily, in a double-blind cross-over trial. The perceptive and cognitive cerebral functions mentioned above were investigated using 5 different tests. A statistically significant improvement in these tests was observed in the treatment group (RRE) during the first two weeks period. No side-effects were reported for either treatment noted. These results suggest that RRE can reduce general fatigue under certain stressful conditions.
http://www.ncbi.nlm.nih.gov/pubmed/11081987
diwe grupy
-placebo
-grupa przyjmujaca RR
badano:zmęczenie psychiczne,spostrzegawcze i poznawcze funkcje mozgu - tj. myslenie,zapamietywanie,liczenie,koncentracja
wniosek:
o grupy stosujacej RR zauwazono znaczna poprawe tych funkcji - co swiadczy o tym ze Rhodiola rosea moze okazac sie pozytecznym suplementem zapobiegajacym ogolnemu zmeczeniu czy pomocna w warunkach stresowych.
A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work.
A randomized, double-blind, placebo-controlled, parallel-group clinical study with an extra non-treatment group was performed to measure the effect of a single dose of standardized SHR-5 Rhodiola rosea extract on capacity for mental work against a background of fatigue and stress. An additional objective was to investigate a possible difference between two doses, one dose being chosen as the standard mean dose in accordance with well-established medicinal use as a psychostimulant/adaptogen, the other dose being 50% higher. Some physiological parameters, e.g. pulse rate, systolic and diastolic blood pressure, were also measured. The study was carried out on a highly uniform population comprising 161 cadets aged from 19 to 21 years. All groups were found to have very similar initial data, with no significant difference with regard to any parameter. The study showed a pronounced antifatigue effect reflected in an antifatigue index defined as a ratio called AFI. The verum groups had AFI mean values of 1.0385 and 1.0195, 2 and 3 capsules respectively, whilst the figure for the placebo group was 0.9046. This was statistically highly significant (p < 0.001) for both doses (verum groups), whilst no significant difference between the two dosage groups was observed. There was a possible trend in favour of the lower dose in the psychometric tests. No such trend was found in the physiological tests.
http://www.ncbi.nlm.nih.gov/pubmed/12725561
badano 3 grupy:
-placebo
-grupe przyjmujaca RR
-grupe przyjmujaca RR o 50% wiecej niz poprzednia
wnioski:
wedlug anti fatigue index (indeks antyzmeczeniowy?)
u grupy placebo zmeczenie bylo o 20-30% wieksze
A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen.
The objective was to investigate the stimulating and normalizing effect of the adaptogen Rhodiola rosea extract SHR-5 in foreign students during a stressful examination period. The study was performed as a double-blind, randomized and placebo-controlled with low repeated dose regime. The study drug and the placebo were taken for 20 days by the students during an examination period. The physical and mental performance were assessed before and after the period, based on objective as well as on subjective evaluation. The most significant improvement in the SHR-5 group was seen in physical fitness, mental fatigue and neuro-motoric tests (p <0.01). The self-assessment of the general well-being was also significantly (p < 0.05) better in the verum group. No significance was seen in the correction of text tests or a neuro-muscular tapping test. The overall conclusion is that the study drug gave significant results compared to the placebo group but that the dose level probably was suboptimal.
http://www.ncbi.nlm.nih.gov/pubmed/10839209
w porownaniu do grupy placebo - grupa przyjmujaca RR wykazala sie lepsza sprawnoscia fizyczna,mniejszym zmeczeniem umyslowym i polepszonym samopoczuciem
Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression.
The objective of this study was to assess the efficacy and safety of standardized extract SHR-5 of rhizomes of Rhodiola rosea L. in patients suffering from a current episode of mild/moderate depression. The phase III clinical trial was carried out as a randomized double-blind placebo-controlled study with parallel groups over 6 weeks. Participants, males and females aged 18-70 years, were selected according to DSM-IV diagnostic criteria for depression, the severity of which was determined by scores gained in Beck Depression Inventory and Hamilton Rating Scale for Depression (HAMD) questionnaires. Patients with initial HAMD scores between 21 and 31 were randomized into three groups, one of which (group A: 31 patients) received two tablets daily of SHR-5 (340 mg/day), a second (group B: 29 patients) received two tablets twice per day of SHR-5 (680 mg/day), and a third (group C: 29 patients) received two placebo tablets daily. The efficacy of SHR-5 extract with respect to depressive complaints was assessed on days 0 and 42 of the study period from total and specific subgroup HAMD scores. For individuals in groups A and B, overall depression, together with insomnia, emotional instability and somatization, but not self-esteem, improved significantly following medication, whilst the placebo group did not show such improvements. No serious side-effects were reported in any of the groups A-C. It is concluded that the standardized extract SHR-5 shows anti-depressive potency in patients with mild to moderate depression when administered in dosages of either 340 or 680 mg/day over a 6-week period.
http://www.ncbi.nlm.nih.gov/pubmed/17990195
badano wplyw RR na osoby cierpiace na łagodna lyb umierkowaną depresje
byly 3 grupy
-placebo
-grupa przyjmujaca RR w dawce 340mg/dzien
-grupa przyjmujaca RR w dawce 680mg/dzien
wyniki po 6-ciu tygodniach:
u grup przyjmujacych RR znaczaco poprawila sie emeocjonalna niestabilznosc czy objawy depresji zlagodnialy
A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue.
The aim of the study was to assess the efficacy of the standardised extract SHR-5 of roots of Rhodiola Rosea L. in the treatment of individuals suffering from stress-related fatigue. The phase III clinical trial took the form of a randomised, double-blind, placebo-controlled study with parallel groups. Participants, males and females aged between 20 and 55 years, were selected according to the Swedish National Board of Health and Welfare diagnostic criteria for fatigue syndrome. A total of 60 individuals were randomised into two groups, one ( N = 30) of which received four tablets daily of SHR-5 extract (576 mg extract/day), while a second ( N = 30) received four placebo tablets daily. The effects of the extract with respect to quality of life (SF-36 questionnaire), symptoms of fatigue (Pines' burnout scale), depression (Montgomery -Asberg depression rating scale - MADRS), attention (Conners' computerised continuous performance test II - CCPT II), and saliva cortisol response to awakening were assessed on day 1 and after 28 days of medication. Data were analysed by between-within analyses of variance. No serious side effects that could be attributed to the extract were reported. Significant post-treatment improvements were observed for both groups (placebo effect) in Pines' burnout scale, mental health (SF-36), and MADRS and in several CCPT II indices of attention, namely, omissions, commissions, and Hit RT SE. When the two groups were compared, however, significant effects of the SHR-5 extract in comparison with the placebo were observed in Pines' burnout scale and the CCPT II indices omissions, Hit RT SE, and variability. Pre- VERSUS post-treatment cortisol responses to awakening stress were significantly different in the treatment group compared with the control group. It is concluded that repeated administration of R. ROSEA extract SHR-5 exerts an anti-fatigue effect that increases mental performance, particularly the ability to concentrate, and decreases cortisol response to awakening stress in burnout patients with fatigue syndrome.
http://www.ncbi.nlm.nih.gov/pubmed/19016404
byly dwie grupy
-placebo
-grupa przyjmujaca extraxt z RR w dawce 576mg/dzien
efekty po 28dniach:
w porownaniu do grupy placebo - u grupy przyjmujacej RR zauwazono spadek zmeczenia co skutkowalo polepszeniem pracy umyslowej,polepszeniem koncentracji i zmniejszeniem poziomu kurtyzolu
Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice.
Rhodiola rosea L., or 'golden root', is a popular plant in traditional medicine in Eastern Europe and Asia, with a reputation for improving depression, enhancing work performance, eliminating fatigue and treating symptoms of asthenia subsequent to intense physical and psychological stress. Due to these therapeutic properties, R. rosea is considered to be one of the most active adaptogenic drugs. To confirm and extend results obtained in the few preclinical and clinical studies available in English language journals, the purpose of the present study was to re-investigate the effects produced by a single oral administration of an R. rosea hydroalcohol extract (containing 3% rosavin and 1% salidroside) on the central nervous system in mice. The extract was tested on antidepressant, adaptogenic, anxiolytic, nociceptive and locomotor activities at doses of 10, 15 and 20 mg/kg, using predictive behavioural tests and animal models. The results show that this R. rosea extract significantly, but not dose-dependently, induced antidepressant-like, adaptogenic, anxiolytic-like and stimulating effects in mice. This study thus provides evidence of the efficacy of R. rosea extracts after a single administration, and confirms many preclinical and clinical studies indicating the adaptogenic and stimulating effects of such R. rosea extracts. Moreover, antidepressant-like and anxiolytic-like activities of R. rosea were shown in mice for the first time.
http://www.ncbi.nlm.nih.gov/pubmed/17072830
podawanie myszom extraktu z RR wykazalo wlasciwosci antydepresyjne,adaptogenne i pobudzajace
Zmieniony przez - solaros w dniu 2011-02-11 02:07:17
"Cóż jest trucizną?
Wszystko jest trucizną i nic nie jest trucizną, tylko dawka czyni, że dana substancja nie jest trucizną!".
BLOG: http://www.sfd.pl/t1033576.html
domer
Krzysztof Piekarz
sfd173
Adramel
djfafa
Marceliz
Cobraf
