Cell Biochem Funct. 2010 Dec 27. [Epub ahead of print]
Taurine supplementation decreases oxidative stress in skeletal muscle after eccentric exercise.
Silva LA, Silveira PC, Ronsani MM, Souza PS, Scheffer D, Vieira LC, Benetti M, De Souza CT, Pinho RA.
Exercise Biochemistry and Physiology Laboratory, Postgraduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil.
Abstract
Infrequent exercise, typically involving eccentric actions, has been shown to cause oxidative stress and to damage muscle tissue. High taurine levels are present in skeletal muscle and may play a role in cellular defences against free radical-mediated damage. This study investigates the effects of taurine supplementation on oxidative stress biomarkers after eccentric exercise (EE). Twenty-four male rats were divided into the following groups (n = 6): control; EE; EE plus taurine (EE + Taurine); EE plus saline (EE + Saline). Taurine was administered as a 1-ml 300 mg kg(-1) per body weight (BW) day(-1) solution in water by gavage, for 15 consecutive days. Starting on the 14th day of supplementation, the animals were submitted to one 90-min downhill run session and constant velocity of 1·0 km h(-1). Forty-eight hours after the exercise session, the animals were killed and the quadriceps muscles were surgically removed. Production of superoxide anion, creatine kinase (CK) levels, lipoperoxidation, carbonylation, total thiol content and antioxidant enzyme were analysed. Taurine supplementation was found to decrease superoxide radical production, CK, lipoperoxidation and carbonylation levels and increased total thiol content in skeletal muscle, but it did not affect antioxidant enzyme activity after EE. The present study suggests that taurine affects skeletal muscle contraction by decreasing oxidative stress, in association with decreased superoxide radical production. Copyright © 2010 John Wiley & Sons, Ltd.
PMID: 21188732 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21188732
Wnioski
Porownując grupe z tauryną i bez, okazało się ze stopien uszkodzenia mięśni po wysiłku był wiekszy u szczurów bez suplementacji taurna niż z nią (analizowano poziom rodnikow tlenowych, kinazy kreatynowej, liperoksydacji, karbonylowania i poziom enzymow antyoksydacyjnych).
Pomimo, ze badania wykonano na modelu zwierzecym, badania moga być punktem wyjscia do rozpoczecia podobnych u ludzi.
Zmniejszenie stresu oksydacyjnego podczas wysiłku, a w zwiazku z tym uszkodzenia mięśni, wpływałoby pozytywnie na skrócenie okresu regeneracji.
Zachecam do dyskusji.
(to moj 1 tekst w tym dziale, jesli cos jest nie tak, to badzcie wyrozumiali )
Zmieniony przez - efedrin w dniu 2011-01-09 13:14:11